Netherlands-Canada Type 2 Diabetes Research Consortium: CIHR Diabetes funded projects
Notice
The information is provided in the language in which it was submitted by the respondent. To review the abstract of each project, please click on the project title hyperlink.
| Principal Investigator | Institution | Program Name | Research Project title | Keywords |
|---|---|---|---|---|
| Abizaid, Alfonso | Carleton University (Ottawa) | Operating Grant | Stress and Obesity: the Ghrelin connection | Ghrelin; Ghrelin Receptors; Hypothalamus; Obesity; Social Stress; Ventral Tegmentum |
| Abizaid, Alfonso | Carleton University (Ottawa) | Operating Grant | Stress and Obesity: the Ghrelin connection | Dorsomedial Nucleus Of The Hypothalamus; Ghrelin; Ghrelin Receptors; Hypothalamus; Nucleus Of The Solitary Tract; Obesity; Parabrachial Nucleus; Social Stress; Ventral Tegmentum |
| Adeli, Khosrow | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Mechanisms of intestinal lipoprotein overproduction in insulin resistant states | Animal Models; Apolipoprotein B; Cell Biology; Diabetes; Insulin Resistance; Intestine |
| Adeli, Khosrow | Hospital for Sick Children (Toronto) University of Toronto |
Foundation Grant | Fundamental and Translational Studies of Diabetic Dyslipidemia in Insulin Resistant States | Biomarkers; Clinical Biochemistry; Laboratory Medicine; Lipoprotein Metabolism; Lipoproteins; Reference Intervals |
| Advani, Andrew | St. Michael's Hospital (Toronto) University of Toronto |
Project Grant | Non-coding RNA in diabetic kidney disease | Animal Models; Cell Culture; Diabetes; Diabetic Complications; Diabetic Nephropathy; Epigenetic; Glucose; Kidney; Long Non-Coding Rna; Translational Research |
| Advani, Andrew | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | Exploring the therapeutic potential of SDF-1 modulation in chronic kidney disease | Chronic Kidney Disease; Diabetic Nephropathy; Focal Segmental Glomerulosclerosis; Hypertension; Sdf-1; Vegf |
| Advani, Andrew | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | JAK2 and podocytes in diabetic nephropathy | Angiotensin Ii; Diabetes; Diabetic Nephropathy; Glucose; Jak2; Kidney; Podocyte |
| Agarwal, Gina (Ragini) | McMaster University | Operating Grant | A Community Paramedicine Initiative for Older Adults Living in Subsidized Housing | Chronic Disease Management; Health Promotion/Disease Prevention; Low Income Older Adults; Paramedics; Qualitative; Quantitative |
| Alarcon, Emilio I | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Project Grant | Multilayer Hybrid Biomaterial for Treatment of Diabetic Foot Ulcers | Collagen Hydrogel; Diabetic Foot Ulcers; Infection; Nanosilver; Tissue Engineering; Wound Healing |
| Alquier, Thierry | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Role of the hypothalamo-pancreatic axis in the pathogenesis of type 2 diabetes | Beta Cell Function; Beta Cell Mass; Hypothalamus; Insulin Sensitivity; Intracellular Metabolism; Neurons; Neuropeptides; Nutrient Sensing Mechanisms; Type 2 Diabetes |
| Alquier, Thierry | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Project Grant | Gliopeptidic regulation of hypothalamic neuronal circuitry by endozepines and energy balance | Astrocytes; Central Nervous System; Endozepines; Energy Balance & Homeostasis; Gliotransmission; Hypothalamus; Melanocortin; Neuroendocrinology; Obesity; Type 2 Diabetes |
| Alquier, Thierry | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Role of the hypothalamo-pancreatic axis in the pathogenesis of type 2 diabetes | Beta Cell Function; Beta Cell Mass; Hypothalamus; Insulin Sensitivity; Nutrient Sensing Mechanisms; Type 2 Diabetes |
| Amed, Shazhan | University of British Columbia | Operating Grant: Knowledge to Action | Tele-SCOPE - Translation, Evaluation and Learnings Exchanged for Sustainable Childhood Obesity Prevention Through Community Engagement | Action; Childhood; Community; Engagement; Exchange; Knowledge; Obesity; Participatory; Prevention; Sustainable |
| Amed, Shazhan | University of British Columbia | Operating Grant: Maternal and Child Health | Developing a framework for evaluating a comprehensive provincial health care model for children with diabetes using existing population databases | British Columbia; Diabetes; Existing Population Databases; Pediatrics; Performance Evaluation Framework; Quality Of Care |
| Amsden, Brian G | Queen's University (Kingston, Ontario) | Operating Grant | Injectable Formulations For Growth Factor Delivery | Biocompatibility; Biodegradable Polymers; Controlled Release; Hepatocyte Growth Factor; Polymer Synthesis; Therapeutic Angiogenesis; Vascular Endothelial Growth Factor |
| Anand, Sonia S | McMaster University | Operating Grant: Fort McKay First Nations Health Alliance | Fort McKay First Nations Health Alliance Cohort Enhancement | Aboriginal People; Air Pollution; Cancer; Cardiovascular; Contextual Factors; Diabetes; Environment; Health Risk Factors; Mri; Obesity |
| Anand, Sonia S | McMaster University | Team Grant - India-Canada Collaborative Teams in Childhood Obesity Research | Understanding the determinants of adiposity among newborns of Indian ancestry in Canada and India. | Birth Cohort; Cardiovascular; Childhood; Culture; Environment; Fetal; Genetic; Maternal; Obesity; South Asian |
| Anand, Sonia S | McMaster University | Foundation Grant | Deciphering the causes of, and developing interventions to reduce, cardio-metabolic risk factors among ethnic groups in Canada | Cardiovascular Disease; Diabetes; Ethnicity; Metabolic Syndrome; Risk Factors |
| Anand, Sonia S | McMaster University | Operating Grant - PA: Aboriginal Ways of Knowing and Two-eyed Seeing (Bridge) | Aboriginal Birth Cohort (ABC) Project | Aboriginal; Birth Cohort; Breastfeeding; Cardiovascular Disease; Childhood Obesity; Infant Nutrition |
| Anand, Sonia S | McMaster University | Operating Grant - PA: First Nations, Inuit and Metis Health | Aboriginal Birth Cohort (ABC) Project | Aboriginal; Birth Cohort; Cardiovascular Disease; Childhood Obesity; Diabetes; Genetics |
| Anand, Sonia S | McMaster University | Operating Grant: Program. Grants in Food & Hlth -Pop Hlth research... | Understanding the impact of maternal and infant nutrition on infant/child health. | Aboriginal; Birth Cohort; Cardio-Metabolic; Dietary Patterns; Epigenetics; Ethnicity; Gene-Diet Interactions; Maternal And Child Health; Microbiome; Nutrition |
| Anderson, Colin C | University of Alberta | Project Grant | Co-inhibitory control of tolerance checkpoints | Autoimmune Disease; Diabetes; Flow Cytometry; Immunology; Tolerance; Transplantation |
| Anderson, Deborah H | University of Saskatchewan | Operating Grant - PA: Regional Partnership Program - Saskatchewan | Regulation of PTEN | Breast Cancer; Pi3k/Pten Pathway; Protein Crystallization & Structure Determination; Protein:Protein Interactions; Surface Plasmon Resonance; Tumor Suppressor Protein |
| Anderson, Laura N | McMaster University | Operating Grant: Population Health Intervention Research | Evaluation of the Healthy Kids Community Challenge in Early Childhood | Disease Prevention; Early Childhood; Epidemiology; Nutrition; Obesity; Physical Activity; Population Health Intervention; Quasi-Experimental |
| Ansley, David M | University of British Columbia | Operating Grant | PRO-TECT II: Propofol cardioprotection for type II diabetics | Antiapoptotic Signaling Pathway; Aortocoronary Bypass Surgery; Apoptosis; Diabetes; Enzyme Assay; Immunohistochemistry |
| Arnason, Terra | University of Saskatchewan | CIHR/Regional Partnership Program/Operating Grants | The role of ubiquitin in the molecular regulation of yeast AMP-activated protein kinase (AMPK), the SNF1 Kinase. | Coimmunoprecipitation; Metabolic Adaptation; Protein Mutagenesis; Protein Stability And Associations; Ubiquitination; Yeast Genetics |
| Atkinson, Stephanie A | McMaster University | Operating Grant | Be Healthy in Pregnancy (BHIP) with Nutrition & Exercise | Body Composition; Clinical Trial; Exercise Intervention; Fetal Determinants Of Infant Outcomes; Knowledge Translation; Maternal Mental Health; Nutritional Intervention; Obesity; Pregnancy Outcomes; Primary Care |
| Lambert, Marie | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant | Predictors and modifiers of the cardiometabolic risk profile in children | Body Composition; Cardiometabolic Risk Factors; Children; Genetics; Growth; Nutrition; Obesity; Physical Activity |
| Batal, Malek | Université de Montréal | Operating Grant: Population Health Intervention Research - Pathways | Evaluation of the Health and Health Equity Outcomes of Okanagan Sockeye Salmon Reintroduction Initiatives | Diet Quality; Ecosystem Recovery; Food Sovereignty; Health Equity; Indigenous Health; Multi-Method Research; Nutrition; Obesity/Diabetes; Qualitative Research; Surveys |
| Beanlands, Rob | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Project Grant | The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events: EvaluatioN of Canakinumab Effectiveness (CADENCE) | Atherosclerosis; Biomarkers; Canakinumab; Cardiovascular Disease; Diabetes; Imaging; Inflammation; Pet |
| Beaulieu, Marie-Dominique | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Impact de la dépression sur les comportements d'autogestion du diabète | Autogestion; Diabète; Dépression; Étude Longitudinale |
| Bello, Aminu | University of Alberta | Project Grant | Systematic-Evaluation-Referral-Treatment for Cardiovascular and Renal Risk in Rural/Remote and Northern Alberta Communities (SMART-CARE) | Diabetes; Early Detection And Management; Hypertension; Indigenous Communities; Kidney Disease |
| Belsham, Denise D | University of Toronto | Operating Grant | Sensing of peripheral nutrient status by the hypothalamus. | Cell Biology; Energy Homeostasis; Hypothalamus; Inflammatory Response; Insulin Resistance; Insulin Signaling; Neuroendocrinology; Neuronal Cell Lines; Neuropeptides; Nutrients |
| Belsham, Denise D | University of Toronto | Operating Grant | Sensing of Peripheral Nutrient Status by the Hypothalamus- from Rodents to Humans. | Cell Biology; Energy Homeostasis; Hypothalamus; Inflammatory Response; Insulin Resistance; Insulin Signaling; Neuroendocrinology; Neuronal Cell Lines; Neuropeptides; Nutrients |
| Bendeck, Michelle P | University of Toronto | Operating Grant | The Role of Discoidin Domain Receptor 1 (DDR1) in Vascular Calcification of Atherosclerosis and Diabetes | Atherosclerosis; Diabetes; Discoidin Domain Receptor; Extracellular Matrix; Intracellular Signaling; Mechanotransduction; Transgenic Mice; Vascular Calcification |
| Bérard, Anick | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant - Secondary Analysis of Databases | Antidepressant use during pregnancy and the risk of pregnancy induced hypertension, gestational diabetes, and post-partum depression. | Administrative Health Data; Antidepressants And Pregnancy; Maternal Depression; Maternal Hypertension; Maternal Post-Partum; Perinatal Epidemiology; Pharmacoepidemiology; Population-Based Research |
| Berger, Howard | St. Michael's Hospital (Toronto) University of Toronto |
Team Grant: Clinician-Investigator Teams in Obstetrics & Maternal-Fetal Medicine | Non-communicable Diseases in Obstetrics: Improving Quality of Care and Maternal-Infant Outcomes through an Obstetrical Research Network | Diabetes In Pregnancy; Health Outcomes; Hypertensive Disorders Of Pregnancy; Knowledge Translation; Obesity; Pregnancy; Prenatal Screening; Quality Of Care |
| Bertolo, Robert F | Memorial University of Newfoundland | Operating Grant | Methyl and methionine metabolism in neonates | Amino Acids; Early Programming Of Adult Diseases; Isotope Kinetics; Metabolism; Methionine; Methyl Groups; Neonate; Parenteral Nutrition; Piglet; Requirements |
| Bertolo, Robert F | Memorial University of Newfoundland | Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador | Impact of dietary methyl groups on methionine metabolism and early programming in neonates | Amino Acids; Early Programming Of Adult Diseases; Isotope Kinetics; Metabolism; Methyl Groups; Piglet; Requirements |
| Beyak, Michael J | Queen's University (Kingston, Ontario) | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Diet induced obesity downregulates gastrointestinal vagal afferent satiety signalling | Electrophysiology; Extracellular Recording; Nodose Ganglion; Obesity; Vagal Afferent; Whole Cell Patch Clamp Recording |
| Beyak, Michael J | Queen's University (Kingston, Ontario) | Operating Grant | Diet induced obesity downregulates gastrointestinal vagal afferent satiety signalling | Electrophysiology; Extracellular Recording; Nodose Ganglion; Obesity; Vagal Afferent; Whole Cell Patch Clamp Recording |
| Biddiss, Elaine A | Holland Bloorview Kids Rehabilitation Hospital (Toronto) University of Toronto |
Operating Grant | Active video games for promotion of physical activity in children and youth with disabilities: Risks and Benefits | Biomechanics; Cerebral Palsy; Exer-Gaming; Metabolic Expenditure; Physical Activity; Qualitative Research |
| Birken, Catherine S | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | PROMOTE: Preschoolers at Risk - Obesity trajectories & cardioMetabolic factors: Towards Early identification | Cardiometabolic Risk Factors; Epidemiology; Lifestyle; Longitudinal Cohort; Nutrition; Obesity Prevention; Preschool Children |
| Blackburn, David F | University of Saskatchewan | Operating Grant | Major Determinants of Non-Adherence in Saskatchewan (MD-NAS) | Health-Administrative Data; Medication Non-Adherence; Pharmacoepidemiology; Questionnaires |
| Blais, Lucie | Université de Montréal | Operating Grant - Secondary Analysis of Databases | Asthma medications during pregnancy and the risk of hypertensive disorders of pregnancy and gestational diabetes | Administrative Databases; Asthma Medications; Cohort Study; Gestationa Diabetes; Hypertensive Disorders Of Pregnancy; Pregnancy |
| Blanchard, Christopher M | Nova Scotia Health Authority (Halifax) Dalhousie University (Nova Scotia) |
Operating Grant - PA: Regional Partnership Program - Nova Scotia | Lifestyle actIvity correlates For diabEtics (LIFE) | Diabetes; Environment; Gender; Physical Activity; Sex |
| Booth, Gillian L | St. Michael's Hospital (Toronto) University of Toronto |
Foundation Grant | Building Healthier Cities: a Canadian Initiative To Identify Environmental Solutions to curb obesity (The 'Healthy Cities, Healthier Lives' Research Program) | Built Environment; Diabetes; Food Environment; Obesity; Physical Activity; Population Health; Prevention; Walkability |
| Booth, Gillian L | Institute for Clinical Evaluative Sciences-Toronto University of Toronto |
Operating Grant | The urban built environment and health: Implications for diabetes prevention | Administrative Data; Built Environment; Diabetes Mellitus; Epidemiology; Food Environment; Neighbourhood Characteristics; Observational Studies; Public/Population Health; Risk Algorithms; Walkability |
| Borradaile, Nica M | University of Western Ontario | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Roles of elongation factor 1A-1 in apolipoprotein B metabolism and the pathogenesis of nonalcoholic fatty liver disease | Apolipoprotein B; Cellular Stress; Lipid; Liver; Nonalcoholic Fatty Liver Disease; Obesity; Type 2 Diabetes |
| Borradaile, Nica M | University of Western Ontario | Operating Grant | Roles of elongation factor 1A-1 in apolipoprotein B metabolism and the pathogenesis of nonalcoholic fatty liver disease | Apolipoprotein B; Cellular Stress; Lipid; Liver; Nonalcoholic Fatty Liver Disease; Obesity; Type 2 Diabetes |
| Bouchard, Luigi | Université de Sherbrooke | Project Grant | Developmental origins of childhood obesity: tracking the causal epigenetic changes programming adiposity in children | Barker Hypothesis; Childhood Obesity; Dna Methylation; Epigenetics/Epigenomics; Epigenome-Wide Analysis Study (Ewas); Foetal Development And Growth; Foetal Metabolic Programming; Gestational Hyperglycemia And Diabetes; Mendelian Randomization |
| Hivert, Marie-France | Université de Sherbrooke | Operating Grant | Evaluation of contributing heritable and environmental factors to adipokine and glycemic regulation variability during pregnancy and fetal development. | Adipokines; Epidemiology; Epigenetic; Fetal Development; Gestational Diabetes; Glucose Regulation; Heritable Risk Factors; Insulin; Prospective Cohort; Quantitative Traits |
| Bouchard, Luigi | Ecogene-21 (Chicoutimi, Québec) | Operating Grant - PA: Reproductive and Child Heath (start-up grants) | Newborn Epigenetic and Transcriptomic Adaptations to Gestational Diabetes Exposure | Birth Weight; Cord Blood; Dna Methylation; Epigenomics; Fetal Programming; Gestationnal Diabetes; Glucose Intolerance; Obesity; Placenta; Transcriptomics |
| Bouchard, Luigi | Hôpital de Chicoutimi (Québec) | Operating Grant: Impact Grant : CEEHRC Phase II | Development of a microRNAs-based panel for early prediction of gestational diabetes mellitus | Child And Youth Health; Early Diagnostic; Foetal Metabolic Programming; Gestational Hyperglycemia And Diabetes; Maternal Health In Pregnancy; Micrornas; Mirna-Sequencing; Transcriptomics |
| Bouchard, Maryse | Université de Montréal | Operating Grant: Analyses of Existing Cohorts & Databases – IHDCYH | Perinatal Exposure to Perfluoroalkyl Substances (PFASs) and Polybrominated Diphenyl Ethers (PBDEs) and Weight Gain Trajectory in Children: Data from the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort | Children; Environmental Contaminants; Obesity; Perfluoroalkyl Substances (Pfass); Polybrominated Diphenyl Ethers (Pbde); Pregnancy Cohort; Prenatal; Sensitive Window Of Exposure; Weight |
| Boucoiran, Isabelle | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Team Grant: Clinician-Investigator Teams in Obstetrics & Maternal-Fetal Medicine | Montreal Emerging Research Team in Maternal Fetal Medicine (MERe) | Clinical Ethics; Gestational Diabetes; Infectious Disease And Pregnancy; Maternal Conditions And Pregnancy; Materno-Fetal Medicine; Prenatal Diagnosis |
| Boulianne, Gabrielle L | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Drosophila Models of Human Obesity | Appetite; Cns; Diet; Drosophila; Feeding Behavior; Gene-Environment Interaction; Gene-Gene Interaction; Genetics; Obesity |
| Boyle, Michael H | McMaster University | Operating Grant | Psychiatric comorbidity in children with chronic physical illness: a pilot study | Child Mental Health; Chronic Illness; Longitudinal Study; Physical Health; Pilot/Feasibility Study; Social Determinant Of Health |
| Braun, Andrew P | University of Calgary | Operating Grant | Endothelial ion channels, nitric oxide and the cellular mechanisms regulating vasorelaxation | Electrophysiology; Endothelium; Hypertension And Diabetes; Nitric Oxide; Vascular Myography And Fluorescence Imaging |
| Braun, Andrew P | University of Calgary | Operating Grant | Targeting endothelial KCa channels in vascular dysfunction. | Calcium Imaging; Calcium-Activated K+ Channels; Electrophysiology; Endothelium; Pressure Myography; Type 2 Diabetes; Vascular Function |
| Brayer, Gary D | University of British Columbia | Operating Grant | Facilitating the Development of New Therapeutics for Diabetes, Pre-Diabetes and Obesity by Inhibition of Human Pancreatic Alpha-Amylase: A Structural and Mechanistic Approach | Diabetes; Enzyme Kinetics; Inhibitor Design And Optimization; Inhibitor Identification And Characterization; Mechanism Based Inhibitor Synthesis; Mechanistic Studies Of Enzymatic Catalysis; Obesity; Protein Structure - Function Relationships; Proteomic Approaches; X-Ray Crystallography |
| Brochu, Michèle | Université de Montréal | Operating Grant | Sexe biologique et environnement intrautérin défavorable: adaptation foetale et conséquences à l'âge adulte | Effet Du Sexe; Modèle Animal; Rein; Restriction De Croissance Intrautérin; Système Cardiovasculaire |
| Brown, Craig E | University of Victoria (British Columbia) | Operating Grant | Imaging the impact of diabetes on brain function and recovery from stroke | Cortical Plasticity; Diabetes; In Vivo Imaging; Recovery; Sensory Systems; Stroke |
| Brown, Craig E | University of Victoria (British Columbia) | Operating Grant | Impact of diabetes on brain function and recovery from ischemic stroke | 2-Photon Microscopy; Angiogenesis; Behaviour; Blood Flow; Diabetes; Imaging; Neural Plasticity; Recovery Of Function; Somatosensory Cortex; Stroke |
| Brown, Hilary | University of Toronto Scarborough (ON) | Project Grant | Chronic Medical Conditions and Perinatal Mental Illness | Chronic Medical Conditions; Postpartum Mental Illness; Prenatal Mental Illness |
| Brubaker, Patricia L | University of Toronto | Project Grant | Mechanisms underlying circadian secretion of the anti-diabetic hormone, glucagon-like peptide-1: therapeutic potential | Cell Signaling; Circadian; Glp-1; Glucose; In Vitro; In Vivo; Insulin; Intestine; Metabolism; Secretion |
| Bruce, Sharon G | University of Manitoba | Operating Grant - PA: Regional Partnership Program : Manitoba | Exploring the role of established and non-traditional risk factors on diabetes and cardiovascular disease among a Manitoba First Nation population. | Aboriginal Health; Cardiovascular Disease; Chronic Disease Etiology; Chronic Diseases; Community Based Participatory Research; Diabetes; Diabetes Complications; Epidemiology; Population Health; Stress |
| Bruce, Sharon G | University of Manitoba | Operating Grant - Aboriginal Health Intervention - full application | Developing a Diabetes Prevention Intervention: Identifying and Targeting Contextually-Relevant Stressors | Community-Based Participatory Research; Diabetes Etiology; Diabetes Prevention; Diabetes Risk Factors; Epidemiology; First Nations People; Intervention Planning; Stress |
| Bruin, Jennifer E | Carleton University (Ottawa) | Project Grant | Contribution of Dioxin-Like Chemicals to Beta Cell Death and Dysfunction in Diabetes | Diabetes; Environmental Pollutants; Insulin; Islets; Toxicology |
| Brumell, John H | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | A novel pathway of PI(3,4)P2/PI(3,4,5)P3 production initiated by a bacterial phosphatase | Confocal Microscopy; Lipid Biochemistry; Membrane Trafficking; Phosphoinositide Signaling; Pi3-Kinase; Salmonella Infection |
| Brumell, John H | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | A novel phosphoinositide signaling pathway contributes to Salmonella pathogenesis | Actin Polymerization; Confocal Microsocpy; Lipid Biochemistry; Membrane Trafficking; Phosphoinositide Signaling; Pi3-Kinase; Rho Gtpase; Salmonella Infection |
| Buckeridge, David L | McGill University/Université McGill | Operating Grant: Advancing Theoretical Method. Innovations Hlth Res - POP | Non-communicable disease indicators for use in a Population Health Record (PopHR): development and validation | Diet; Health Outcomes; Indicators; Non-Communicable Disease; Public Health Informatics; Surveillance |
| Bull, Shelley B | Sinai Health System (Toronto)University of Toronto | Operating Grant | Analytic Methods for the Next Generation of Complex Trait Studies | Complex Traits; Gene By Environment; Genetic Epidemiology; Genome-Wide Studies; Longitudinal Study Design; Statistical Genetics |
| Burger, Dylan E | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Project Grant | Microparticles in Diabetes | Diabetes; Endothelial; Hyperglycemia; Microparticles; Peptidylarginine Deiminase; Thrombospondin; Vascular Dysfunction |
| Burger, Dylan E | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Project Grant | Mechanisms of endothelial microparticle formation and signaling in diabetes | Biomarker; Cell Biology; Diabetes; Endothelial; Extracellular Vesicles; Inflammation; Microparticles; Reactive Oxygen Species; Vascular; Vessel Myography |
| Buschmann, Michael D | École polytechnique de MontréalUniversité de Montréal | Operating Grant: Industry-partnered Collaborative Research - Other Partner | Gene Delivery of Glucagon-like Peptide-1 (GLP-1) for the Treatment of Type 2 Diabetes | Chitosan; Diabetes; Gene Delivery; Glucagon-Like Peptide-1; Nanomedicine |
| Buteau, Jean | University of Alberta | Operating Grant | Role of SirT1 in the regulation of pancreatic beta-cell mass and function | Animal Models; Apoptosis; Diabetes; Gene Expression; Insulin Secretion; Metabolism; Pancreatic Beta-Cells; Proliferation; Transcription Factors |
| Buteau, Jean | University of Alberta | Operating Grant | Glucagon-like peptide-1 and pancreatic beta-cell neogenesis | Diabetes; Differentiation; Growth Factor; Pancreatic Beta-Cell; Proliferation; Signal Transduction |
| Buteau, Jean | University of Alberta | Project Grant | Role of the non-receptor tyrosine kinase Lyn in the regulation of pancreatic beta-cell mass and function | Apoptosis; Beta-Cell; Cell Signalling; Diabetes; Kinase; Proliferation; Signal Transduction |
| Campbell, Robert J | Queen's University (Kingston, Ontario) | Project Grant | Comparative safety of aflibercept and ranibizumab in the treatment of retinal diseases | Aflibercept; Comparative Safety; Drug Safety; Health Services Research; Ophthalmology; Ranibizumab; Retinal Diseases |
| Carpentier, André C | Université de Sherbrooke | Operating Grant | Investigation of postprandial fatty acid metabolism in the natural history of type 2 diabetes mellitus (T2D) | Diabetes Mellitus; Insulin Resistance; Lipid Metabolism; Positron Emission Tomography; Postprandial Lipoprotein Metabolism; Stable Isotopes |
| Carpentier, André C | Université de Sherbrooke | Project Grant | Quantifying Brown Adipose Tissue Thermogenesis in Obesity and Type 2 Diabetes | Brown Adipose Tissue; Energy Metabolism; Fatty Acid Metabolism; Magnetic Resonance Imaging; Molecular Imaging; Obesity; Positron Emission Tomography; Tracer Methods; Triglycerides; Type 2 Diabetes |
| Carpentier, André C | Université de Sherbrooke | Operating Grant | Investigation of postprandial fatty acid metabolism in the natural history of type 2 diabetes mellitus (T2D) | Diabetes Mellitus; Insulin Resistance; Lipid Metabolism; Positron Emission Tomography; Postprandial Lipoprotein Metabolism; Stable Isotopes |
| Carpentier, André C | Université de Sherbrooke | Operating Grant | Mechanisms of improved glucose metabolism after bariatric surgery in type 2 diabetes | Bariatric Surgery; Diabetes Mellitus; Fatty Acid Metabolism; Insulin Resistance/Secretion; Obesity; Postprandial Metabolism |
| Carpentier, André C | Université de Sherbrooke | Operating Grant | Postprandial energy metabolism of brown fat in humans | Brown Adipose Tissue; Diabetes Mellitus; Insulin Resistance; Lipid Metabolism; Positron Emission Tomography; Postprandial Lipoprotein Metabolism; Postprandial Thermogenesis; Stable Isotopes |
| Cattini, Peter A | University of Manitoba | Operating Grant | Activation, Expression and Hormonal Regulation of the Human Pituitary Growth Hormone Gene | Chromatin Remodeling/Gene Activation; Disorders Related To Dysregulation Of Growth Hormone; Hormonal (Glucocorticoid And Insulin) Regulation; Human Pituitary Growth Hormone Gene; Tissue-Specific Regulation; Transcriptional Regulation/Gene Expression |
| Cattini, Peter A | University of Manitoba | Operating Grant - PA: Regional Partnership Program : Manitoba | Obesity and Development of a Diabetes Mellitus-Like State in Pregnancy: Investigating a Role for Regulation of the Human Placental Growth Hormone Genes | Epigenetic Events/Non-Coding Rnas; High Fat Diet-Induced Gestational Diabetes; Human Placenta; Human Placental Hormone Genes; Pregnancy; Transgenic Mice |
| Cechetto, David F | University of Western Ontario | Emerging Team Grant: Co-morb of brain disorders & other health problems-full | CIHR Team in Vascular Cognitive Impairment: Animal Models of Co-morbidity | Alzheimer's Disease; Diabetes; Neurodegeneration; Neuroinflammation; Stroke; Vascular Cognitive Impairment |
| Chakrabarti, Subrata | University of Western Ontario | Project Grant | Novel mechanisms in diabetic cardiomyopathy | Cardiac Functional Changes; Cardiac Structural Changes; Cardiomyocytes; Diabetic Cardiomyopathy; Endothelial Cells; Methylation; Non-Coding Rna |
| Chan, John S | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Reactive Oxygen Species, Bcl-2-Modifying Factor and Tubular Atrophy in Diabetic Kidneys | Bcl-2-Modifying Factor; Diabetic Nephropathy; Glucose Signaling; Insulin Signaling; Kidney; Molecular Biology; Oxidative Stress; Physiology; Renin-Angiotensin System; Transgenic And Knockout Mice |
| Chan, John S | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) in the Progression of Diabetic Nephropathy: Friend or foe? | Angiotensinogen; Diabetes; Diabetic Nephropathy; Heterogeneous Nuclear Ribonucleoproteins; Hypertension; Knockout Mice; Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2); Oxidative Stress; Renin-Angiotensin System; Transgenic Mice |
| Chan, John S | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Diabetes and the mechanism(s) of renal tubular apoptosis in db/db mouse kidneys | Albumin; Angiotensinogen; Caspase-12 Gene Expression; Diabetic Nephropathy; Molecular And Cell Biology; Oxidative Stress; Renal Proximal Tubular Cells; Renin-Angiotensin System; Transgenic Mice; Tubular Apoptosis And Atrophy |
| Chan, John S | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Hypertension and regulation of angiotensinogen gene expression in transgenic mice | Angiotensinogen Gene; Diabetes; Heterogenous Ribonucleoprotein F; Hypertension; Kidney; Transgenic Mice |
| Cheeseman, Christopher I | University of Alberta | Operating Grant | Characterization of a novel urate transporter in the kidney and colon. | Electrophysiology; Heterologous Expression; Metabolic Disease; Pcr; Site Directed Mutagenesis; Urate Transport |
| Chemtob, Sylvain | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Foundation Grant | Choroidopathies in retinopathies: pathogenesis and therapeutic discoveries | Aging; Angiogenesis; Choroid; Inflammation; Ischemia; Newborn; Oxidant Stress; Photoreceptors; Retina; Vasoobliteration |
| Chemtob, Sylvain | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Proof of Principle Program - Phase II | IL-1 Allosteramers to treat diabetes and its complications | Allosteramer; Diabetes; Il-1beta; Inflammation; Interleukin |
| Chevalier, Stéphanie | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Protein metabolism and insulin resistance in cancer cachexia: a potential anabolic role of leucine | Gluconeogenesis; Insulin Resistance; Leucine; Lung Cancer; Protein Metabolism; Stable Isotope Kinetic Studies |
| Chin Sang, Ian D | Queen's University (Kingston, Ontario) | Operating Grant | The Role of Eph and Insulin Receptor Tyrosine Kinase Signaling in C. elegans Neurodevelopment | Axon Guidance; C. Elegans; Cancer; Cell Migration; Eph Receptor Tyrosine Kinase; Genetics; Insulin Signaling; Morphogenesis; Pten; Signal Transduction |
| Chin Sang, Ian D | Queen's University (Kingston, Ontario) | Project Grant | The role of Insulin signaling in neuronal development. | C. Elegans; Cell Biology; Genetics; Insulin Growth Factors; Insulin Signaling; Neurodevelopment; Neuropeptides |
| Christian, Sherri L | Memorial University of Newfoundland | Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador | Mechanisms of molecular regulation of pre-adipocyte differentiation by CD24 | Adipogenesis; Bioinformatics; Cd24; Gene Expression Profiling; Gene Expression Regulation; Lipodystrophies; Obesity; Pre-Adipocyte; Signal Transduction |
| Cianflone, Katherine M | Institut universitaire de cardiologie et de pneumologie de Québec - ULaval Université Laval |
Operating Grant | ASP Deficient and ASP Excess Mice Models: Immune-Metabolic Interactions in Adipose Tissue and Energy Expenditure Regulation | Adipose Tissue; Cell Biology; Diabetes; Mice Models; Obesity; Peptide Hormones |
| Cianflone, Katherine M | Université Laval | CANADA-HOPE Scholarship Program - Operating Grant | Hormonal and Mechanistic Evaluation of Increasing risk of diabetes and Cardiovascular Disease in India: from Bench to Bedside. | Adipokines; Adipose Tissue; Cardiovascular Disease; Insulin Resistance; Subcutaneous; Visceral |
| Clandinin, Michael T | University of Alberta | Operating Grant | Physiological factors that determine quantity of in vivo synthesis of palmitate, palmitoleate, stearate and oleate in humans | Chronic Disease Risk; De Novo Lipogenesis; Fat Metabolism; Human Research; Stable Isotopes; Substrate Utilization |
| Coderre, Terence J | McGill University/Université McGill | Proof of Principle Program - Phase I | Synergistic topical combinations for chronic pain aimed at treating microvascular dysfunction. | Allodynia; Commercialization; Laser Doppler; Microvascular Dysfunction; Nociception; Pain; Side-Effects; Synergy; Tissue Oxygenation; Topical Application |
| Cole, William C | University of Calgary | Operating Grant | Integrin Adhesion Signaling in the Cerebral Arterial Myogenic Response | Cerebral Blood Flow Autoregulation; Cytoskeleton Reorganization; Goto-Kakizaki Type 2 Diabetic Rat; Myogenic Response; Myosin Light Chain Phosphatase; Rho Kinase Phosphorylation; Spontaneously Hypertensive Rat; Stroke-Prone Hypertensive Rat; Vascular Smooth Muscle; Vasoconstrictor |
| Cole, William C | University of Calgary | Operating Grant | The Cerebral Arterial Myogenic Response in Health and Disease | Cerebral Blood Flow Autoregulation; Cytoskeleton Reorganization; Goto-Kakizaki Type 2 Diabetic Rat; Myogenic Response; Myosin Light Chain Phosphatase; Rho Kinase Phosphorylation; Spontaneously Hypertensive Rat; Stroke-Prone Hypertensive Rat; Vascular Smooth Muscle; Vasoconstrictor |
| Connelly, Philip W | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | Investigating the role of red blood cells in oxidative stress and thrombogenesis - from 4-hydroxynonenal chemistry to mouse to man. | Alpha; Beta Unsaturated Aldehydes; Diabetes; Gamma-Glutamyltranspeptidase; Glutathione; Paraoxonase 1; Platelets; Red Blood Cells |
| Corbett, Dale R | Memorial University of Newfoundland | Operating Grant | Recovery of function following stroke | Aging; Behaviour; Co-Morbidity; Neuroplasticity; Recovery Of Function; Stroke |
| Cordes, Sabine P | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Analysis of the role of the Gumby gene in angiogenesis | Angiogenesis; Craniofacial Syndromes; Development; Molecular Genetics; Mouse Genetics |
| Couture, Patrick | Université Laval | Operating Grant | Effects of medium-chain triglycerides on chylomicron secretion and expression of genes that regulate intestinal lipid metabolism in men with dyslipidemia associated with the metabolic syndrome | Gene Expression; Intestinal Lipoprotein Metabolism; Metabolic Syndrome |
| Couture, Patrick | Université Laval | Operating Grant | Differential effects of saturated and polyunsaturated fatty acids on chylomicron secretion and expression of key genes and proteins that regulate intestinal lipid metabolism in men with dyslipidemia associated with insulin-resistance | Gene Expression; Insulin-Resistance; Intestinal Lipoprotein Metabolism; Nutrition; Proteomic |
| Couture, Patrick | Université Laval | Project Grant | Differential effects of saturated and monounsaturated fatty acids on chylomicron secretion and the expression of key genes that regulate intestinal lipid metabolism in insulin-resistant subjects | Gene Expression; Insulin-Resistance; Intestinal Lipoprotein Metabolism; Nutrition |
| Couture, Réjean | Université de Montréal | Operating Grant | Kinin B1 receptor as a key target in the treatment of hypertension and insulin resistance | Arterial Hypertension; Cardiovascular; Central Nervous System; Insulin Resistance; Oxidative Stress; Pharmacology; Vascular Inflammation; Vasoactive Peptides |
| Cross, Karen M | St. Michael's Hospital (Toronto) University of Toronto |
Project Grant | Development of the MultIspectral MObile tiSsue Assessment (MIMOSA) device | Magnetic Resonance; Methemoglobin; Multispectral; Optical Imaging; Oxygenation; Tissue Perfusion |
| Crowshoe, Lynden L | Alberta Health ServicesUniversity of Alberta | Project Grant | Educating For Equity: Indigenous Patient Empowerment through Critical Education of Patients and Physicians in Addressing Social Pathways to Diabetes | Care Framework; Health Literacy; Indigenous; Patient Empowerment; Primary Care; Psycho-Education; Type 2 Diabetes |
| Cullis, Pieter R | University of British Columbia | Foundation Grant | Lipid nanomedicines for health and disease | Anticancer; Drug Delivery System; Gene Therapy; Immunosuppressant; Lipid Nanoparticles; Mrna; Nanomedicine; Sirna; Small Molecule Drugs; Trigger Release |
| Cummins, Carolyn L | University of Toronto | Operating Grant: Industry-partnered Collaborative Research | Defining the structural basis for LXR beta antagonism | Co-Transfection Assays; Dexamethasone; Ligand Binding Assays; Liver X Receptor; Nuclear Receptor; P450 Metabolism; Physicochemical Properties; Primary Hepatocytes; Structure Based Drug Design; Synthetic Chemistry |
| Cummins, Carolyn L | University of Toronto | Project Grant | Nuclear Receptor Signaling in High-Fat Diet and Glucocorticoid-Induced Metabolic Disease | Adipose; Arglu1; Chromatin Immunoprecipitation; Coregulator; Energy Expenditure; Glucocorticoid; Liver; Metabolic Disease; Nuclear Receptor; Rna-Seq |
| Cummins, Carolyn L | University of Toronto | Operating Grant | Role of LXRbeta in Glucocorticoid-Induced Hyperglycemia | Diabetes; Glucocorticoids; Glucose Metabolism; Knockout Mice; Lxr; Signalling |
| Cummins, Carolyn L | University of Toronto | Proof of Principle Program - Phase I | Developing a Novel Therapeutic for Cushing's Syndrome | Cushing's Syndrome; Diabetes; Drug Target; Glucocorticoid; Glucocorticoid Receptor; Liver X Receptor; Muscle Wasting; Obesity; Osteoporosis |
| Cummins, Carolyn L | University of Toronto | Operating Grant | Molecular Determinants of Corticosteroid Actions in Glucose Metabolism | Animal Model; Chromatin Immunoprecipitation; Coactivator; Fgf21; Glucocorticoid Receptor; Gluconeogenesis; Hepatosteatosis; Liver X Receptor Beta; Lxr Antagonist; Stress Hormone |
| Dacosta, Ralph S | University Health Network (Toronto) University of Toronto |
Project Grant | The FL.I.G.H.T (Fluorescence Image-Guided Healing Trial) for Diabetic Foot Ulcers: A Single Centre Phase II Trial | Bacteria; Diabetes Wound Complications; Diabetic Foot Ulcers; Fluorescence Imaging; Health Economics; Microbiology; Quality Of Life; Wound Debridement; Wound Healing; Wound Sampling |
| Dagher, Alain | Montreal Neurological Institute/Institut neurologique de Montréal McGill University/Université McGill |
Operating Grant | Ghrelin and the CNS control of appetite. | Fmri; Ghrelin; Obesity; Reward; Stress |
| Dallaire, Clémence | Université Laval | Partnerships for Health System Improvement (PHSI) | L'implantation d'une clinique de suivis intégrés de maladies chroniques en misant sur la deuxieme ligne de soins | Diabète; Implantation d'un suivi; Maladies inflammatoires; Pratiques de gestion; Pratiques professionnelles; Suivi des maladies chroniques |
| Danska, Jayne S | Hospital for Sick Children (Toronto) University of Toronto |
Project Grant | Mechanisms of Inflammation, Immunity and Islet Dysfunction in Diabetes (MI3D) | Flow Cytometry; Gene/Environment Interaction; Genomic Analysis; Gut Microbiome; Human Cohort Studies; Human Diabetes; Immune Responses; Innate Immune Surveillance; Mouse Models; Type 1 Diabetes |
| Dart, Allison B | University of Manitoba | Operating Grant | An assessment of psychological factors, inflammatory biomarkers and kidney complications; the Improving renal Complications in Adolescents with type 2 diabetes through REsearch (iCARE) cohort study | Albuminuria; Biomarkers; Cohort; Inflammation; Psychological Factors; Type 2 Diabetes Mellitus; Youth |
| Dasgupta, Kaberi | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Step Monitoring to improve ARTERial health (SMARTER) | Arterial Stiffness; Behaviour; Cardiovascular Disease Risk Factors; Diabetes; Hypertension; Obesity; Pedometers; Physical Activity; Randomized Controlled Trial |
| Dasgupta, Kaberi | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Project Grant | Amplifying the Step Monitoring to improve ARTERial health strategy (SMARTER amplify) | Applications; Cardiometabolic Risk Factors; Coaching; Pedometers; Peers; Physical Activity |
| Dasgupta, Kaberi | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant: Sugar and Health - Sugars and Health | Sugar in solid foods and beverages: examining relationships to gestational diabetes and cardiovascular disease | Free Sugars; Gestational Diabetes; Myocardial Infarction; Stroke |
| DaSilva, Jean N | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Altered Angiotensin II AT1 Receptor in Cardiac and Renal Disease: Translational Development of Novel F-18 Labeled Ligands for PET Imaging | Candesartan; Diabetes; Echocardiography; Fluoro-18 Analogs; Heart Failure; Hypertension; Losartan; Pet Imaging |
| DaSilva, Jean N | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | Effect of Glycemic Therapy on Impaired Myocardial Noradrenergic Innervation and Beta-Adrenoceptors in Rat Models of Diabetes | Cardiovascular Diseases; Hyperglycemia; Insulin Resistance; Noradrenaline; Positron Emission Tomography; Type 2 Diabetes |
| Dawes, Martin G | University of British Columbia | Pfizer Operating Grant in Disease Prevention and Management | Preventing Diabetes with Facilitated Lifestyle Intervention Prescriptions. Phase 2: Pilot Study | Access To Preventive Care; Behaviour Modification; Clinical Trial; Collaborative Practice; Health Promotion; Patient Self-Management Education; Pilot Study; Pre-Diabetes; Primary And Community-Based Healthcare |
| De Koninck, Yves | Centre hospitalier Robert-Giffard (Québec) | Operating Grant | Plasticity of inhibition in spinal sensory pathways | Behavioural Pharmacology; Cellular Imaging; Chronic Pain; Electrophysiology; Gaba / Glycine; Immunocytochemistry |
| Delormier, Treena | McGill University/Université McGill | Operating Grant: Network Environments for Indigenous Health Research- Dev Grants | Title: Ratikonshatatie, "the faces yet to come": KSDPP Center for Research and Training for Community Mobilization and Knowledge Translation | Capacity Building; Community Mobilisation; Health Promotion; Indigenous Health Research; Knowledge Translation |
| Des Rosiers, Christine | Montreal Heart Institute/Institut de cardiologie de Montréal Université de Montréal |
Operating Grant | Investigations of cardiac metabolism using mass isotopomer analysis: A paradigm for biomarker and therapy discovery. | Cardiac Energy Metabolism; Cardiomyopathy; Cgmp Signaling; Diabetes; Heart Perfusion; Mass Spectrometry; Mitochondria; Positron Emission Tomography |
| Després, Jean-Pierre | Institut universitaire de cardiologie et de pneumologie de Québec - ULaval Université Laval |
Operating Grant | Visceral obesity/ectopic fat and non-invasive markers of atherosclerosis: A cardiometabolic-cardiovascular imaging study | Atherosclerosis; Cardiometabolic Risk Factors/Markers; Cardiorespiratory Fitness; Cardiovascular Disease And Type 2 Diabetes; Visceral Adiposity/Ectopic Fat |
| Devlin, Angela M | University of British Columbia | Project Grant | Maternal Folic Acid and Vitamin B12 intake During Pregnancy and Type 2 Diabetes Risk in Offspring | Developmental Programming; Diabetes; Folic Acid; Islets; Offspring; Pregnancy; Vitamin B12 |
| Dionne, Isabelle | Centre de recherche sur le vieillissement (QC) Université de Sherbrooke |
Operating Grant - Priority Announcement: Obesity | Metabolic Characteristics of Overweight Postmenopausal Women First-Degree Relatives of Type 2 Diabetes patients (FDR): How are they different from non-FDR and how do they respond to exercise training? | Body Composition; Ct Scan; Exercise; Fat Metabolism; Glucose Tolerance; Muscle Tissue; Type 2 Diabetes |
| Dodds, Linda | IWK Health Centre (Halifax) Dalhousie University (Nova Scotia) |
Operating Grant | Vitamin D status in Canadian pregnant women and their newborn infants: what levels protect against adverse pregnancy outcomes? | 25-Hydroxy Vitamin D; Birth Weight; Cohort; Gestational Diabetes; Nested Case-Control; Pre-Eclampsia; Pregnancy; Small For Gestational Age; Vitamin D |
| Dolinsky, Vernon W | University of Manitoba | Operating Grant | Adiponectin in gestational diabetes and the developmental origins of disease. | Adiponectin; Developmental Origins Of Disease; Gene Expression; Gene Therapy; Gestational Diabetes; Hepatic Steatosis; Insulin Resistance; Islet Biology; Mitochondria; Obesity |
| Dosch, Hans-Michael | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | The Immunology and Neuroscience of Diabetes Mellitus. | B6 Mouse & Congenics; Diet Induced Obesity (Dio); Nod Mouse; Primary Sensory Afferent Neurons; T1d & T2d Patients; Trpv1; Trpv1 Allelic Variants; Type 1 Diabetes (T1d); Type 2 Diabetes (T2d); Visceral Fat-Resident Lymphocytes |
| Doucette, Christine A | University of Manitoba | Project Grant | Examining the mechanistic impact of the HNF-1aG319S polymorphism on beta cell function and its contribution to early-onset type 2 diabetes | Beta Cells; Gene Expression; Glucose-Sensing; Islet Biology; Metabolism; Type 2 Diabetes |
| Douros, Antonios | Lady Davis Institute for Medical Research (Mtl) McGill University/Université McGill |
Project Grant | Concomitant use of sulfonylureas with warfarin and the risk of severe hypoglycemia in patients with type 2 diabetes | Anti-Diabetic Treatment; Drug-Drug Interaction; Hypoglycemia; Oral Anticoagulants; Type 2 Diabetes |
| Drouin, Jacques | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant | Transcriptional and epigenetic mechanisms for differentiation of pituitary POMC cells | Cell Differentiation; Chromatin; Pax; Pioneer Factor; Pituitary; Pomc; Repression; Tbox; Transcriptional Coactivators |
| Drucker, Daniel J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Molecular and cellular mechanisms of dipeptidyl peptidase-4 action | Cardiovascular System; Diabetes; Gut Endocrine System; Peptide Hormones |
| Drucker, Daniel J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Foundation Grant | Mechanisms of peptide hormone action: metabolic and therapeutic implications | Gut And Islet Hormones; Metabolism |
| Drucker, Daniel J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Gipr and the control of glucose homeostasis | Diabetes; Intestine; Obesity; Peptide Hormones |
| Drucker, Daniel J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Glucagon receptor and the control of metabolism | Diabetes; Gut Endocrine System; Metabolism; Peptide Hormones |
| Drucker, Daniel J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Elucidation of novel mechanisms of glucagon action | Intestine; Pancreas; Peptide Hormones; Receptors |
| Dubrac, Alexandre | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Project Grant | ALK5-PAR6A signaling pathway regulates endothelial cells proliferation and vascular leakage | Angiogenesis; Cell Polarity; Cell Proliferation; Endothelial Cell; Neonatal Vascular Malformation; Retinopathy; Tgfb |
| Dyck, Jason R | University of Alberta | Operating Grant | The Role of Adipose Triglyceride Lipase in the Pathogenesis of Lipotoxic Cardiomyopathy | Adipose Triglyceride Lipase; Ampk; Cardiac Metabolism; Lipid Accumulation; Lipotoxic Cardiomyopathy |
| Ehses, Jan A | University of British Columbia | Operating Grant-PA: INMD Start Up Funds (bridge funding) - New Investigators | Targeting anti-inflammatory macrophages to treat type 2 diabetes | Diabetes; Inflammation; Insulin; Islets Of Langerhans; Macrophages; Pancreatic Beta Cell |
| Ehses, Jan A | University of British Columbia | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | The role of islet macrophages in obesity and type 2 diabetes: from pro-inflammation to regeneration. | Diabetes; Inflammation; Insulin; Islets Of Langerhans; Macrophages; Pancreatic Beta Cell; Regeneration |
| Engler-Stringer, Rachel R | University of Saskatchewan | Operating Grant: Population Health Intervention Research | The Good Food Junction: A Community-Based Food Intervention to Reduce Nutritional Health Inequities | Community-Based Research; Mixed Methods; Nutrition Inequalities Research; Population Health Intervention |
| Estall, Jennifer | Institut de recherches cliniques de Montréal Université de Montréal |
Project Grant | PGC-1a co-activators in beta-cell function and survival | Apoptosis; Beta-Cells; Diabetes; Insulin Secretion; Islet; Metabolism; Mouse Models; Pgc-1; Snp; Transcription |
| Estall, Jennifer | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant - PA: INMD Start-up Funds (Clinicians and New Investigators) | Transcriptional regulators of beta-cell health, function, and diabetes | Apoptosis; Beta-Cells; Glucose Homeostasis; Immune Cells; Inflammation; Insulin; Metabolism; Pgc-1; Polymorphism; Transcriptional Co-Regulators |
| Estall, Jennifer | Institut de recherches cliniques de MontréalUniversité de Montréal | Operating Grant-PA: INMD Start Up Funds (bridge funding) - New Investigators | Transcriptional Regulation of Fatty Liver Disease | Biomarker; Fatty Liver Disease; Fibrosis; Inflammation; Insulin Resistance; Metabolism; Mitochondria; Pgc-1alpha; Reactive Oxygen Species; Transcription |
| Eurich, Dean | University of Alberta | Project Grant | Reorganizing the Approach to Diabetes through the Application of Registries (RADAR) | Diabetes; First Nations; Health Outcomes; Intervention |
| Eurich, Dean | University of Alberta | Operating Grant | International Population-Based Evaluation of Drug Therapies Used to Manage Type 2 Diabetes | Cardiovascular System; Diabetes; Health Outcomes; Mortality; Pharmacotherapy; Population Health |
| Eurich, Dean | University of Alberta | Operating Grant | The Impact of Drug Exposure Misclassification on Study Estimates of Clinical Outcomes in Administrative Drug Databases | Health Outcomes; Pharmacotherapy; Policy; Population Health |
| Eurich, Dean | University of Alberta | Operating Grant | Effectiveness of Sitagliptin in Patients with Diabetes and Heart Failure: Population Based Cohort Study | Diabetes; Drug Therapy; Health Services; Heart Failure; Mortality |
| Ezzat, Shereen Z | University Health Network (Toronto) University of Toronto |
Operating Grant | Fibroblast Growth Factor Receptor 4 in Endocrine Homeostasis | Cell Growth; Endocrine Tumors; Endocrinology; Hormone Regulation |
| Fantus, Ivan G | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Project Grant | Novel mediators of thioredoxin-interacting protein in diabetes complications. | Diabetes Mellitus; Diabetic Nephropathy; Kidney Disease |
| Fantus, Ivan G | University Health Network (Toronto) University of Toronto |
Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | The role of TxNIP in the development of diabetic nephropathy. | Diabetes Complications; Diabetic Nephropathy; High Glucose; Mesangial Cells; Nadph; Oxidase; Oxidative Stress; Reactive Oxygen Species (Ros); Thioredoxin-Interacting Protein (Txnip) |
| Fantus, Ivan G | Toronto General Hospital University of Toronto |
Operating Grant | Interactions between cGMP and insulin cell signaling pathways: Physiology and molecular mechanisms of regulation of insulin sensitivity. | Adipocytes; Glucose Uptake; Insulin Resistance; Insulin Signaling; Type 2 Diabetes Mellitus; Tyrosine Phosphatase |
| Fantus, Ivan G | University Health Network (Toronto) University of Toronto |
Operating Grant | Tyrosine kinase signaling in the pathogenesis of diabetic nephropathy. | Albuminuria; Glucose Metabolism; Metabolism; Proteins; Tyrosine Kinase |
| Faraj, May | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant-PA: INMD Start Up Funds (bridge funding) - Clinician Scientists | ApoB-lipoproteins, adipose tissue NLRP3 inflammasome and insulin resistance | 12 Weeks Omega-3 Fatty Acids-Rich Diet; In Vivo And And Ex Vivo Human And Mice Models; Innate Immunity And Nlrp3 Inflammasome; Insulin Sensitivity And Secretion; Lipids And Apob-Lipoproteins; Overweight And Obese Subjects; Postprandial Fat Clearance; Stable And Radioactive Isotope Tracing; White Adipose Tissue Function |
| Faraj, May | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant | The inflammasome and dysfunctional adipose tissue: why should apoB-lipoproteins be targeted in humans | 16 Wks Omega-3 Fatty Acids Supplementation; Clinical Study In Obese Subjects; In Vivo And And Ex Vivo Models; Innate Immunity And Nlrp3 Inflammasome; Insulin Sensitivity And Secretion; Lipoprotein Metabolism; Postprandial Dietary Fat Clearance; Stable And Radioactive Isotope Tracing; White Adipose Tissue Function |
| Faraj, May | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant | Targeting hyperapoB vs normoapoB to reduce the risk of type 2 diabetes in obese subjects; mechanism of action | 24 Weeks Hypocaloric Diet Intervention; Blood & Adipose Tissue); Fatty Acid Trapping (In Vivo & Ex Vivo In Adipose Tissue); Inflammation (In Vivo & Ex Vivo; Insulin Sensitivity (In Vivo & Ex Vivo In Adipose Tissue); Lipids & Apob-Lipoproteins (Size; Number & Oxidation); Obese Subjects With High Versus Low Serum Apob100 |
| Faraj, May | Institut de recherches cliniques de MontréalUniversité de Montréal | Project Grant | White adipose tissue LDL receptors and omega-3 as modulators of the risk for type 2 diabetes | Chronic Inflammation And Innate Immunity; Clinical And Basic Studies; Insulin Secretion And Sensitivity; Ldlr And Cd36; Lipoprotein Metabolism; Macrophages; Nlrp3 Inflammasome; Pcsk9; Type 2 Diabetes; White Adipose Tissue |
| Faulkner, Guy | University of Toronto | Operating Grant | Identifying and Measuring Correlates and Determinants of Physical Activity in Individuals with Schizophrenia | Accelerometry; Correlates; Determinants; Epidemiology; Intervention; Obesity; Physical Activity; Schizophrenia |
| Faulkner, Guy | University of Toronto | Operating Grant - Priority Announcement: Obesity | Identifying and Measuring Correlates and Determinants of Physical Activity in Individuals with Schizophrenia | Accelerometry; Correlates; Determinants; Epidemiology; Intervention; Obesity; Physical Activity; Schizophrenia |
| Feig, Denice S | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Project Grant | Metformin in Women with Type 2 Diabetes in Pregnancy (MiTy) Trial: A randomized controlled trial | Diabetes In Pregnancy; Metformin; Pregnancy Outcomes; Randomized Controlled Trial; Type II Diabetes |
| Feig, Denice S | Sinai Health System (Toronto) University of Toronto |
Operating Grant | The MiTY Trial (Metformin in Women with Type 2 Diabetes in Pregnancy) | Pregnancy; Randomized Controlled Trial; Type 2 Diabetes |
| Feig, Denice S | Sinai Health System (Toronto) University of Toronto |
Operating Grant | MiTy Kids (Metformin in Women with Type 2 Diabetes in Pregnancy Kids Trial) | Childhood Obesity; Pregnancy; Type 2 Diabetes |
| Feig, Denice S | Sinai Health System (Toronto) University of Toronto |
Project Grant | MiTy: Metformin in Women with Type 2 Diabetes in Pregnancy: A randomized controlled trial. | Diabetes In Pregnancy; Metformin; Pregnancy Outcomes; Randomized Control Trial; Type II Diabetes |
| Ferguson, Alastair V | Queen's University (Kingston, Ontario) | Operating Grant | The Subfornical Organ - A critical central nervous system sensor and integrator of metabolic, cardiovascular and immune signals in the circulation. | Camp; Central Autonomic Control; Cholecystokinin; Circumventricular Organs; Gene Expression; Hypertension; Insulin; Obesity; Patch Clamp Electrophysiology |
| Fernyhough, Paul | University of Manitoba | Operating Grant - PA: Regional Partnership Program : Manitoba | Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair. | Animal Models; Chemotherapy-Induced Neuropathy; Confocal Imaging; In Vivo Electrophysiology; Mitochondria; Muscarinic Receptors; Nerve Regeneration; Pain Sensitivity; Peripheral Neuropathy; Sensory Neuron |
| Ferro, Mark | University of Waterloo (Ontario) | Project Grant | Multimorbidity in Children and Youth Across the LIFEcourse (MY LIFE) | Child/Adolescent Health; Children And Adolescents; Cohort Study; Health Service Use; Health Trajectories; Multilevel Modeling; Multimorbidity; Physical Activity; Physical And Mental Health |
| Ferron, Mathieu | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant | Role of vitamin K-dependent gamma-carboxylation in glucose metabolism | Bone; Diabetes; Gamma-Carboxylation; Glucose Metabolism; Insulin; Islets; Obesity; Osteoblasts; Osteocalcin; Vitamin K |
| Filion, Kristian B | Lady Davis Institute for Medical Research (Mtl) McGill University/Université McGill |
Project Grant | Incretin-based Drugs and the Risk of Adverse Renal Outcomes | Acute Kidney Injury; Database; Dpp-4 Inhibitors; Drug Safety; Epidemiology; Glp-1 Analogs; Incretin-Based Drugs; Kidneys; Pharmacoepidemiology; Type 2 Diabetes |
| Filion, Kristian B | CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General/CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Hôpital juif McGill University/Université McGill |
Operating Grant | Gestational Diabetes Mellitus and the Risk of Incident Cardiovascular Disease | Cardiovascular Disease; Database; Epidemiology; Gestational Diabetes; Myocardial Infarction; Pregnancy; Risk Stratification; Stroke |
| Forster, Alan J | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Information systems-enabled outreach program for Adverse Drug Events | Adherence; Health Services Research; Information Technology; Patient Safety; Pharmacoepidemiology |
| Fortier, Isabel | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant: Canadian DOHaD Cohort Registry | Research Advancement through Cohort Cataloguing and Harmonization (ReACH) | Cohorts; Data Discovery; Data Harmonization/Integration; Developmental Origins Of Health And Diseases; Early Life Trajectories; Metadata Catalogue; Open Source Software Development; Pregnancy/Birth Cohorts |
| Fraser, Graham M | Memorial University of Newfoundland | Project Grant | Microvascular Blood Flow Regulation and Insulin Resistance in an Animal Model of Type 2 Diabetes | Capillary Blood Flow; Endothelial Function; Glucose Uptake; Hyperglycaemia; Insulin Resistance; Mass Transport; Mathematical Modelling; Microcirculation; Microvascular Blood Flow Regulation; Type 2 Diabetes |
| Fraser, Paul E | University of Toronto | Proof of Principle Program - Phase I | Amyloid-Based Therapies for Type 2 Diabetes | Beta Cells; Diabetes; Islet Amyloid; Peptide Chemistry; Pharmacokinetics |
| Fulton, Stephanie | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Project Grant | Targeting alpha-beta-hydrolase domain 6 in the neural control of body weight, reward and mood | Endocannabinoids; Energy Expenditure; Feeding; Gaba; Mood; Motivation; Neuropharmacology; Nucleus Accumbens; Obesity; Reward |
| Gaisano, Herbert Y | University of Toronto | Project Grant | Novel excitosomes mediating exocytosis in neuroendocrine cells | Calcium Channels; Electrophysiology; Exocytosis; Insulin Granule Exocytosis; Islet Beta Cells; Potassium Channels; Reserve Pool; Snare Proteins; Tirf-Sim Microscopy |
| Gaisano, Herbert Y | University of Toronto | Operating Grant | Rescuing the insulin exocytotic defects in type 2 diabetes | Cytoskeleton; Diabetes; Evanescent Microscopy; Insulin Exocytosis; Lentivirus; Multiphoton Microscopy; Patch Clamp Electrophysiology; Snare Proteins |
| Gaisano, Herbert Y | University of Toronto | Project Grant | Role of autophagy dysregulation in pancreatitis caused by alcohol and glucagon-like peptide | Alcoholic Pancreatitis; Autophagy; Glp-1 Induced Pancreatitis; Human Pancreas; Snare Proteins |
| Gaisano, Herbert Y | University of Toronto | Operating Grant | Mechanisms of pancreatitis elucidated on human pancreas in situ | Alcoholic Pancreatitis; Glucagon Like Peptide 1; Human Pancreas; Pathologic Exocytosis; Snare Proteins |
| Gaisano, Herbert Y | University of Toronto | Operating Grant | Rescuing insulin exocytotic defects in type 2 diabetes | Cytoskeleton; Diabetes; Evanescent Microscopy; Insulin Exocytosis; Lentivirus; Multiphoton Microscopy; Patch Clamp Electrophysiology; Snare Proteins |
| Gaisano, Herbert Y | University of Toronto | Operating Grant | SNARE regulation of potassium channels in neuroendocrine cells | Diabetes; Evanescent Microscopy; Exocytosis; Pancreatic Islet; Patch Clamp; Potassium Channels |
| Galloway, Tracey L | University of Toronto | Operating Grant - PA: First Nations, Inuit and Metis Health | The impact of proposed change in federal health funding policy on health programs operating in Yukon First Nations communities | Aboriginal Health; Community Health; Disease Prevention; Health Policy; Health Programs; Maternal-Child Health; Nutrition; Physical Activity; Population Health; Public Health |
| Gamble, John-Michael | University of Waterloo (Ontario) | Project Grant | Comparative Safety of the Sodium Glucose Co-transporter-2 (SGLT-2) Inhibitors in Patients with Type 2 Diabetes | Antidiabetic Medications; Database Analysis; Diabetes Mellitus; Drug Safety; Health Outcomes; Observational Study; Pharmacoepidemiology; Population Health |
| Gamble, John-Michael | Memorial University of Newfoundland | Operating Grant | Comparative Safety and Effectiveness of the Incretins | Cohort Study; Comparative Effectiveness Research; Database Analysis; Diabetes; Drug Safety And Effectiveness; Health Outcomes; Pharmacoepidemiology; Population Health |
| Garcia Bengoechea, Enrique | McGill University/Université McGill | Operating Grant: Knowledge to Action | Participatory Policy Intervention to Promote School-Based Physical Activity | Aboriginal Health; Community Health; Community-Based Participatory Research; Health Promotion; Implementation Study; Integrated Knowledge Translation; Physical Activity Intervention; Policy Intervention; School-Based Intervention |
| Gaudet, Laura M | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Team Grant: Clinician-Investigator Teams in Obstetrics & Maternal-Fetal Medicine | OaK 2016-2021: Investigating Contemporary Topics in OB/MFM | Assisted Reproductive Technology; Obesity; Pregnancy; Triage Tool |
| Gaudreau, Pierrette | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Deciphering the characteristics and functions of a novel growth hormone-releasing hormone receptor in the kidney | Cell Proliferation; Cell Signaling; Cell Survival; In Vivo Studies; Kidney; Rat Models; Receptor Characterization; Renal Cell Culture |
| Geraldes, Pedro M | Université de Sherbrooke | Project Grant | Mechanisms of insulin resistance in podocytes and diabetic nephropathy | Diabetic Nephropathy; Insulin; Insulin Receptor; Phosphatase; Podocytes; Protein Kinase C |
| Geraldes, Pedro M | Université de Sherbrooke | Operating Grant | Role of SHP-1 in poor collateral vessel formation and angiogenic response in diabetes. | Angiogenesis; Collateral Vessel Formation; Diabetes; Endothelial Cells; Pdgf; Peripheral Arterial Disease; Phosphatase; Shp-1; Smooth Muscle Cells; Vegf |
| Geraldes, Pedro M | Université de Sherbrooke | Operating Grant | New mechanisms of podocyte injury in diabetic nephropathy | Diabetic Nephropathy; Epigenetics; Insulin; Insulin Resistance; Mtor; Nephrin; Podocytes; Protein Kinase C; Shp-1; Vegf |
| Geraldes, Pedro M | Université de Sherbrooke | Project Grant | Phosphatases and mechanisms of poor collateral vessel formation in diabetes | Angiogenesis; Diabetes; Endothelial Cells; Limb Ischemia; Pdgf; Phosphatase; Vegf |
| Giacca, Adria | University of Toronto | Project Grant | Hepatic signalling of glucose and lipid metabolism in vivo | Diabetes; Free Fatty Acids; Hyperinsulinemic Clamp; In Vivo; Inflammation; Insulin Resistance; Lipotoxicity; Liver; Obesity; Tracer Methodology |
| Giacca, Adria | University of Toronto | Operating Grant | Novel mediators of beta-cell lipotoxicity | Beta Cell; Diabetes; Free Fatty Acids; Hyperglycemic Clamp; In Vivo; Inflammation; Lipotoxicity; Obesity; Oxidative Stress; Sirtuins |
| Giacca, Adria | University of Toronto | Project Grant | The role of NOD1 in obesity-associated diabetes | Damage Associated Molecular Patterns; Fat; Innate Immunity; Pattern Recognition Receptors |
| Gibson, William T | University of British Columbia | Operating Grant | Rare Obesity Disorders Informing Common Disease | Extreme Phenotypes; Genomics; Health Of Vulnerable Populations(Children With Disabilities); Mechanisms Shared Between Common And Rare Diseases; Obesity And Diabetes |
| Gibson, William T | University of British Columbia | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Rare Obesity Disorders Informing Common Disease | Extreme Phenotypes; Genomics; Health Of Vulnerable Populations(Children With Disabilities); Mechanisms Shared Between Common And Rare Diseases; Obesity And Diabetes |
| Gibson, William T | BC Children's Hospital Research Institute University of British Columbia |
Project Grant | Regulation of islet cell proliferation by p300 | Beta Cell; Glucose Tolerance; Mouse Models Of Human Disease; P300; Transcriptional Coactivators |
| Gibson, William T | BC Children's Hospital Research Institute University of British Columbia |
Project Grant | Insights from Rare Overgrowth Syndromes for Common Diseases | Cancer; Congenital Anomalies; Dna Methylation; Exome Sequencing; Histone Acetyltransferases; Histone Methyltransferases; Intellectual Disability; Obesity; Overgrowth; Rare Diseases |
| Gignac, Monique A | Institute for Work & Health (Toronto) University of Toronto |
Operating Grant | Employment needs and experiences of workers with arthritis and diabetes: Keeping the Boom(ers) in the labour market. | Aging; Arthritis; Baby Boomers; Chronic Episodic Health Conditions; Diabetes; Employment; Older Workers; Psycholsocial Factors |
| Giguere, Vincent | McGill University/Université McGill | Operating Grant | Transcriptional control of metabolism by the estrogen related receptors (ERRs) | Diabetes; Functional Genomics; Metabolism; Molecular Biology; Nuclear Receptors; Transcription |
| Giguere, Vincent | McGill University/Université McGill | Operating Grant | The ERR pathway: control of energy metabolism and its implication in metabolic disorders | Diabetes; Functional Genomics; Gene Expression; Lipid Disorders; Metabolism; Metabolomics; Micro Rna; Mouse Models; Obesity |
| Gilbert, Richard E | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | The Role of Sirtuin1 in Diabetic Nephropathy: Experimental and Clinical Studies | Diabetes; Humans; Kidney Disease; Mice |
| Gilliland, Jason A | University of Western Ontario | Project Grant | Development and Evaluation of a Smartphone Based Program for Improving Food Literacy and Healthy Eating Among Youth | Behaviour Change; Child And Youth Health; Dietary Behaviours; Food Environments; Food Literacy; Healthy Eating; Nutritional Messaging; Overweight/Obesity; Smartphones; Surveys |
| Gilliland, Jason A | University of Western Ontario | Project Grant | Evaluation of a Smartphone Based Intervention for Improving Food Literacy, Food Purchasing, and Diet Quality Among Youth in Urban, Suburban, and Rural Environments | Behaviour Change; Child And Youth Health; Dietary Behaviours; Food Environments; Food Literacy; Healthy Eating; Nutritional Messaging; Overweight/Obesity; Smartphones; Surveys |
| Gilron, Ian | Queen's University (Kingston, Ontario) | Randomized Controlled Trials | Combination pharmacotherapy for the management of pain (2008) | Analgesic Pharmacology; Anticonvulsants; Antidepressants; Chronic Pain; Clinical Pharmacology; Controlled Trials; Diabetic Neuropathy; Drug Combinations; Neuropathic Pain; Opioids; Pain; Pain Measurement; Randomized |
| Williams, Jason | Nova Scotia Health Authority (Halifax) | Proof of Principle Program - Phase II | The Production of Decellularized Human Skin to Treat Chronic Diabetic Ulcers | Chronic Wounds; Decellularized Dermis; Diabetes; Diabetic Ulcer; Human Trial; Tissue Engineering; Wound Healing |
| Glazner, Gordon W | St. Boniface General Hospital Research Centre (Winnipeg) University of Manitoba |
Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | Targeting the cytokine/NF-kB axis in diabetic neuropathy | Cytokine; Diabetic Neuropathy; Mitochondria; Neurotrophic Factors; Nf-Kappab; Oxidative Stress |
| Glazner, Gordon W | St. Boniface General Hospital Research Centre (Winnipeg) University of Manitoba |
Operating Grant - PA: Regional Partnership Program : Manitoba | Targeting the cytokine/NF-kB axis in diabetic neuropathy | Cytokine; Diabetic Neuropathy; Mitochondria; Neurotrophic Factors; Nf-Kappab; Oxidative Stress |
| Godwin, Marshall S | Memorial University of Newfoundland | Operating Grant | Health Coaching to Effect Lifestyle Behaviour Change: A Randomized Trial of Individuals with Pre-disease | Cardiovascular Disease; Cardiovascular Lifestyle; Lifestyle Modification; Nurse Coaching; Pre-Disease |
| Gramolini, Anthony O | University of Toronto | Operating Grant | Modeling cardiovascular development using human stem cells | Cardiac Development; Cardiac Progenitors; Cell Biology; Cell Surface; Mass Spectrometry; Proteomics; Stem Cells |
| Grant, Michael D | Memorial University of Newfoundland | Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream | Cytomegalovirus Immune Memory Inflation and Immunosenescence in Human Immunodeficiency Virus Infection | Age-Related Morbidity; Cytomegalovirus; Hiv Infection; Immune Suppression; Immunosenescence; Memory Inflation; Trec Assay |
| Grant, Michael D | Memorial University of Newfoundland | Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador | Cytomegalovirus Immune Memory Inflation and Immunosenescence in Human Immunodeficiency Virus Infection | Age-Related Morbidity; Cytomegalovirus; Hiv Infection; Immune Suppression; Immunosenescence; Memory Inflation; Trec Assay |
| Greenblatt, Jack F | University of Toronto | Project Grant | Mechanisms of gene regulation by the human C2H2 zinc finger proteins and interacting RNAs | C2h2 Zinc Finger Proteins; Chia-Pet; Chip-Sequencing; Clip-Sequencing; Dna Looping; Lumier; Net-Sequencing; Protein-Protein Interactions; Protein-Rna Interactions; Rna Polymerase II |
| Greenwood, Carol E | Baycrest Centre for Geriatric Care (Toronto) University of Toronto |
Operating Grant | Neurocognitive Correlates of Hypertension and Type 2 Diabetes in Older Adults | Adaptive Responses; Brain Aging; Cognitive Function; Fmri; Hypertension; Type 2 Diabetes Mellitus |
| Grimshaw, Jeremy M | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Seeing the forests and the trees - Innovative approaches to exploring heterogeneity in systematic reviews of complex knowledge translation interventions to enhance policy decision making | Complex Interventions; Knowledge Translation; Meta-Subsets Analysis; Patient Care And Outcomes; Policy Decision Making; Quality Improvement Interventions |
| Volchuk, Allen O | University Health Network (Toronto) | Operating Grant | The Endoplasmic Reticulum Stress Response in Pancreatic Beta-Cells | Animal Models; Cellular Stress Response; Endoplasmic Reticulum Stress; Pancreatic Beta Cells; Primary Cultured Cells; Type 2 Diabetes |
| Grundberg, Elin | McGill University/Université McGill | Foundation Grant | Understanding etiology of metabolic diseases by integrative genomics and epigenomics approaches | Epigenetics; Next-Generation Sequencing; Obesity; Type 2 Diabetes |
| Gruneir, Andrea | Women's College Hospital (Toronto) University of Toronto |
Operating Grant | Repeat Emergency Department Visits Among Long-Term Care Residents in Ontario | Emergency Department Visits; Linked Administrative Data; Long-Term Care; Older Adults; Repeat Events Models; Transitions |
| Gucciardi, Enza | Ryerson University (Toronto) | Operating Grant | Mobile Diabetes Education Teams in Primary Care | Coordinated And Integrated Care; Diabetes Care; Diabetes Education Programs; Diabetes Self-Management Education; Health Services; Implementation And Evaluation; Interprofessional Collaboration; Patient Care Processess; Primary Care Physicians; Qualitative; Quantitative |
| Gutkowska, Jolanta | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Pleiotropic effects of oxytocin | (Ot); Cardioprotection; Cell Differentiation; Diabetes; Glucose Uptake; Heart; Ot Elongated Form- (Ot-Gkr); Oxytocin |
| Gutkowska, Jolanta | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | The role of brain natriuretic peptide and oxytocin in prevention of metabolic and cardiovascular complications in diabetes. | Diabetes; Natriuretic Peptides; Oxytocin; Treatment |
| Haas, Tara L | York University (Toronto, Ontario) | Operating Grant | Microvascular remodeling of the adipose and muscle tissues in diet-induced obesity: regulation by FoxO proteins | Angiogenesis; Capillaries; Extracellular Matrix; Transcriptional Regulation |
| Haddad, Pierre S | Université de Montréal | Operating Grant - PA: Applying the “Two-eyed Seeing” model to Aboriginal Health | The best of both worlds: Developing strategies to provide safe and culturally appropriate access to Traditional Medicines for diabetes care in contemporary Aboriginal primary healthcare. | Aboriginal Health; Health Services; Primary Community Health Care; Traditional Medicine |
| Haddad, Pierre S | Université de Montréal | Team Grant: Pathways Implementation Research Team – Component 2 | Uniting Traditional Ways and Science around medicinal plants/foods for the better prevention and management of Type 2 Diabetes in Canadian First Nations | Aboriginal Health; Community Workshops; Cultural Relevant Physical Cctivities; Diabetes; Foods; Medicinal Plants; Participatory Community Based Research; Public Health Policies; Safety And Efficacy Of Medicinal Plants; Traditional Knowledge |
| Hahn, Margaret | Centre for Addiction and Mental Health (Toronto)/Centre de toxicomanie et de santé mentale University of Toronto |
Project Grant | Unraveling the role of central insulin action in relation to glucose abnormalities in first-time antipsychotic users | Antipsychotics; Cognition; Diabetes; Psychosis |
| Hajek, Tomas | Nova Scotia Health Authority (Halifax) Dalhousie University (Nova Scotia) |
Operating Grant | Is type 2 diabetes mellitus a risk factor for neuroanatomical changes, cognitive impairment and oxidative stress in bipolar disorders? | Bipolar Disorders; Brain Imaging; Cognitive Testing; Peripheral Biomarkers; Type 2 Diabetes Mellitus |
| Hammond, David G | University of Waterloo (Ontario) | Operating Grant: Population Health Intervention Research | Nutritional labeling on menus in Canada and the United States: Evidence to inform policy. | Health Behaviour; Health Policy; Labelling; Nutrition; Obesity Prevention; Policy Evaluation |
| Hammond, David G | University of Waterloo (Ontario) | Project Grant | International food policy study: Evaluating the impact of food labelling, marketing, and fiscal nutrition policies. | Diet; Food Policy; Health Behaviour; Nutrition |
| Hammond, Geoffrey L | University of British Columbia | Operating Grant | Sex hormone-binding globulin: beyond the plasma transport of sex steroids. | Androgen; Estrogen; Genetic Polymorphisms; Molecular And Cell Biology; Reproduction; Sex Hormone-Binding Globulin; Transcription; Transgenic Mouse; Type 2 Diabetes |
| Han, Victor Khin M | University of Western Ontario | Operating Grant | Placental mesenchymal stem cells in regenerative therapy | Cell Signaling; Cerebral Ischemia; Diabetes; Insulin-Like Growth Factors; Mesenchymal Stem Cells; Placenta; Regenerative Therapy; Tissue Environment; Tumorigenesis; Umbilical Cord Blood |
| Hanley, Anthony J | University of Toronto | Operating Grant | Understanding the effects of social, behavioural and metabolic factors on early childhood growth trajectories among Aboriginal Canadians | Aboriginal Health; Breast Feeding; Diabetes Mellitus (Type 2); Epidemiology; Infant And Child Growth; Nutrition; Overweight; Population Health |
| Hanley, Anthony J | University of Toronto | Operating Grant - PA: First Nations, Inuit and Metis Health | Understanding the Importance of Newly Identified Diabetes Risk Factors among Aboriginal Canadians: The Sandy Lake Health and Diabetes Project | Aboriginal Health; Diabetes Mellitus (Type 2); Epidemiology; Infant Growth; Population Health; Vitamin D |
| Hanley, Anthony J | University of Toronto | Operating Grant | Plasma non-esterified fatty acids and the progression of insulin resistance and pancreatic beta-cell dysfunction: a novel targeted omics approach. | Beta Cell Dysfunction; Diabetes Mellitus; Insulin Resistance; Non-Esterefied Fatty Acids; Type 2 |
| Hanning, Rhona M | University of Waterloo (Ontario) | Team Grant: Pathways Implementation Research Team – Component 2 | Refining a Scaling Up Strategy for Bringing Local Healthy Food to School through Learning Circles in First Nations and Métis Communities | Community Capacity Building; Culture; First Nations; Food Systems; Healthy Eating; Knowledge Translation And Exchange; Metis; Scaling Up; Social Capital |
| Haqq, Andrea M | University of Alberta | Operating Grant | Evaluation of autonomic nervous system function, body fat distribution and metabolic profile in children with PWS. | Adipocytokines; Autonomic Nervous System; Body Composition; Childhood Obesity; Hormones; Nutrition; Pediatrics; Prader-Willi Syndrome; Visceral Fat |
| Harper, Mary-Ellen | University of Ottawa/Université d'Ottawa | Operating Grant | Mitochondrial Uncoupling in Skeletal Muscle: Molecular Mechanisms to Whole Body Implications | Mitochondria; Muscle; Obesity; Reactive Oxygen Species; Type 2 Diabetes Mellitus; Uncoupling Proteins |
| Harper, Mary-Ellen | University of Ottawa/Université d'Ottawa | Foundation Grant | Mitochondrial Bioenergetics and Redox Biology in Obesity and Related Disease | Bioenergetics; Diet; Exercise; Metabolic Programming; Mitochondria; Mitochondrial Disorders; Oxidative Stress; Protein Post-Translational Modification; Reactive Oxygen Species; Redox Reactions |
| Harris, Stewart B | University of Western Ontario | Operating Grant: Network Environments for Indigenous Health Research- Dev Grants | Indigenous Network for Health Advancement | Chronic Disease; Community-Based Participatory Research; Diabetes Mellitus; Environmental Dispossession; Food Environments; Indigenous Wellness; Quality Improvement; Traditional Food Systems |
| Hawker, Gillian A | Women's College Hospital (Toronto) University of Toronto |
Project Grant | Development & Piloting of a Patient and Provider-Level Behavior Change Intervention to Increase Physical Activity in People with Diabetes through Diagnosis and Management of Concomitant Knee Osteoarthritis | Diabetes; Knee Osteoarthritis; Patient Oriented Research; Physical Activity; Physiotherapy; Primary Care; Quality Of Care; Specialty Care |
| Hayden, Michael R | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | microRNA regulation of ABCA1 and its impact on beta cell function | Abca1; Beta Cells; Cholesterol; Diabetes; Microrna; Mouse Models |
| Hebert, Richard L | University of Ottawa/Université d'Ottawa | Operating Grant | Tubular dysfunction in diabetes: role of PGE2/EP receptors | Apoptosis; Cell Growth; Diabetic Nephropathy; Ep1 Knockout Mouse; Fibrosis; Fvb And Diabetic (Ove-26) Mouse Model; Isolated Perfused Mouse Cortical Collecting Duct; Isolated Perfused Mouse Proximal Tubules; Sodium Transport; Water Flow |
| Hegele, Robert A | University of Western Ontario | Foundation Grant | Clinical translation of genomic understanding of cardiometabolic risk | Atherosclerotic Cardiovascular Disease; Cardiometabolic Risk; Diabetes; Dyslipidemia; Human Genetics And Genomics; Investigational Therapies; Molecular Diagnosis; Next Generation Dna Sequencing; Obesity; Risk Factors |
| Hegele, Robert A | University of Western Ontario | Operating Grant | Genetic architecture of cardiometabolic risk in families and communities. | Atherosclerosis; Diabetes; Genetic Association Analysis; Lipids; Metabolic Syndrome; Risk Factors |
| Henderson, Melanie | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Project Grant | Linking lifestyle behaviors, microbiota & cardiometabolic health from childhood to early adulthood: The QUALITY Cohort. | Cardiovascular Disease Risk; Diet; Fitness; Gut Microbiota; Obesity; Oral Microbiota; Physical Activity; Sedentary Behaviours; Type 2 Diabetes |
| Lambert, Marie | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant | Towards the prevention of type 2 diabetes: improving our understanding of longitudinal changes in glucose homeostatis in youth | Adolescent; Cardiometabolic Risk Factors; Cohort Study; Impaired Fasting Glucose; Impaired Glucose Homeostasis; Impaired Glucose Tolerance; Obesity; Type 2 Diabetes |
| Hirasawa, Michiru | Memorial University of Newfoundland | Project Grant | Mechanism for high fat diet-induced activation of MCH neurons and its role in obesity | Energy Homeostasis; Food Intake; High Fat Diet; Hypothalamus; Inflammation; Melanin Concentrating Hormone; Obesity; Prostaglandin |
| Hivert, Marie-France | Université de Sherbrooke | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Evaluation of contributing heritable and environmental factors to adipokine and glycemic regulation variability during pregnancy and fetal development. | Adipokines; Epidemiology; Epigenetic; Fetal Development; Gestational Diabetes; Glucose Regulation; Heritable Risk Factors; Insulin; Prospective Cohort; Quantitative Traits |
| Hoffman, Brad G | University of British Columbia | Project Grant | Determining the role of histone modifications in mediating transcriptional consistency in beta-cells and in diabetes pathogenesis | Beta-Cell; Chromatin Structure; Diabetes; Histone Modifications; Transcriptional Regulation; Trithorax Complex |
| Hoffman, Brad G | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | Determining Myt3's role in beta-cell maturation, function and inflammatory response. | Apoptosis; Diabetes; Gene Regulation; Glucose-Stimulated Insulin Secretion; Transcription Factors |
| Holloway, Alison C | McMaster University | Project Grant | E-cigarette use during pregnancy: Impact on metabolic health of the offspring | Dysmetabolism; E-Cigarettes; Early Life Origins Of Health; Maternal Smoking; Nicotine; Obesity |
| Holloway, Alison C | McMaster University | Operating Grant | Antidepressant use during pregnancy and the risk of metabolic disturbances in the offspring | Antidepressants; Beta Cell; Fetal Programming Of Adult Disease; Obesity; Pregnancy; Type 2 Diabetes |
| Howell, Doris M | University Health Network (Toronto) University of Toronto |
Partnerships for Health System Improvement (PHSI) | Integration of a Disease Self-Management Approach in the Cancer System to Optimize Health and Living with Cancer: A Road Map for Implementation | Chronic Disease Self-Management |
| Huff, Murray W | University of Western Ontario | Operating Grant | Regulation of intestinal lipoprotein overproduction in insulin resistant states by citrus flavonoids. | Atherosclerosis; Chylomicrons; Dyslipidemia; Flavonoids; Insulin Signaling; Mouse Model Of Insulin Resistance; Obesity; Very Low Density Lipoproteins |
| Hui, Chi-Chung | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Irx3 and Irx5 as novel genetic factors controlling energy homeostasis | Adipocyte; Body Mass Index; Diabetes; Energy Homeostasis; Fto; Genetic Mouse Models; Hypothalamus; Iroquois Homeobox Genes; Mass Spectrometry; Obesity |
| Hurley, Jeremiah E | McMaster University | Operating Grant: Economic Forecasting | Investing in Primary and Secondary Prevention: Economic Forecasting to Inform Policies Regarding Amortization of Program Costs | Amortization; Autism; Diabetes Prevention; Early Psychosis Intervention; Economic Forecasting; Economics Of Prevention; Health Economics; Innovative Public Finance; Intergenerational Violence; Public Sector Budgeting |
| Husain, Mansoor | Toronto General Research Institute University of Toronto |
Project Grant | Cardiovascular effects of GLP-1(28-36): focus on heart failure. | Glucagon-Like Peptide; Heart Failure; Metabolism; Mouse Models Of Disease; Transgenic Mice |
| Hutton, Eileen K | McMaster University | Operating Grant | The Baby & Microbiota of the Intestine Project (Baby & Mi) | Antibiotic Exposure; Child Health; Cohort Study; Intestinal Microbiota; Neonatal Health; Obesity; Pregnancy |
| Jacobs, Rene L | University of Alberta | Operating Grant | The central role of the vagus nerve in high fat diet-induced obesity | Energy Expenditure; Gene Regulation; High-Fat Diet; Nutrition; Vagus Nerve |
| Jacobs, Rene L | University of Alberta | Project Grant | Intestinal phosphatidylcholine synthesis, dietary lipid handling and the metabolic syndrome | Diet-Gene Interaction; High Fat Diet; Intestine; Knockout Mice; Lipoproteins; Phosphatidylcholine |
| Jardine, Cynthia | University of Alberta | Operating Grant: Pathways Implementation Research Team – Component 1 | Indigenous Youth as Agents of Change for Community Wellness: Promoting Resilience and Positive Youth Development | Health Promotion; Indigenous; Participatory Research; Resilience; Self-Efficacy; Suicide Prevention; Wellness; Youth |
| Jefferies, Wilfred A | University of British Columbia | Operating Grant | Characterization of Functional L-Type Calcium Channels in Lymphocytes | Arthritis; Cacna1f; Diabetes; Mouse Models; T-Lymphocyte; Voltage-Gated Calcium Channel |
| Jenkins, David J | University of Toronto | Knowledge Synthesis Grant | Effect of dietary pulses on cardiometabolic risk in humans: A series of systematic reviews and meta-analyses to provide evidence-based guidance for nutrition guidelines development. | Beans; Blood Pressure; Body Weight; Cardiovascular Diease; Chickpeas; Controlled Feeding Trials; Diabetes; Lentils; Meta-Analysis; Metabolic Syndrome; Nutrition; Peas; Systematic Review |
| Jenkins, David J | University of Toronto | Operating Grant | The effect of an enhanced dietary portfolio plus exercise on cardiovascular risk in high risk individuals. | Cardiovascular Disease Prevention; Cvd Risk; Diabetes; Diet; Dietary Cholesterol; Feasibility; Functional Foods; Glycemic Index; Inflammatory Biomarkers; Lipid Analysis; Monounsaturated Fat; Nuts; Plant Sterols; Saturated Fat; Vegetable Protein; Viscous Fiber |
| Jenkins, David J | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant - Randomized Controlled Trials Mentoring Program | Low-Glycemic Index Diet and Other Intervention Trials (RCTs) in Type 2 Diabetes and Cardiovascular Disease | Arterial Damage; Dietary Interventions; Ecoptic Fat; Glycemic Index; Intramyocellular Fat; Magnetic Resonance Imaging (Mri); Obesity; Randomized Controlled Trials; Type 2 Diabetes; Visceral Fat |
| Jenkins, David J | University of Toronto | Randomized Controlled Trials | Low Glycemic index diet to improve glycemic control and cardiovascular disease in type 2 diabetes | Blood Glucose And Lipid Control; Dietary Intervention; Intima Media Thickness (Imt); Intra Plaque Hemorrhage (Iph); Low Glycemic Index (Gi); Magnetic Resonance Imaging (Mri); Type 2 Diabetes |
| Jenkins, David J | University of Toronto | Operating Grant: Programmatic Grants in Food and Health - Full application | Canada-Wide Human Nutrition Trialists' Network. | Arterial Plaque; Canadian Network; Cardiovascular Disease; Diabetes; Dietary Trials; Genetics; Knowledge Synthesis And Translation; Magnetic Resonance Imaging And Imaging; Metabolic Syndrome; Obesity |
| Jin, Tianru | University Health Network (Toronto) University of Toronto |
Operating Grant | A novel mechanism in controlling the expression of ChREBP and liver lipogenesis | Chramatin Immunoprecipitation (Chip); Chrebp; Insulin Resistance; Liver Lipogenesis; Transcriptional Repression; Transgenic Mice |
| Jin, Tianru | University Health Network (Toronto) University of Toronto |
Project Grant | Metabolic functions of the Wnt signaling pathway | Beta-Catenin; Estrogen; Gene Expression; Glp-1; Gluconeogenesis; Insulin; Lipid Metabolism; Tcf7l2; Transgenic Mouse Models; Wnt |
| Johnson, James D | University of British Columbia | Operating Grant | Mechanisms of insulin receptor trafficking and signalling in beta-cells | Autocrine Feedback; Caveolin; Endocytosis And Endosomes; High Fat Diet And Lipotoxicity; Hyperinsulinemia; Insulin Receptor Signalling; Insulin Resistance; Pancreatic Islets; Signal Transduction; Type 2 Diabetes |
| Johnson, James D | University of British Columbia | Operating Grant | Effects of circulating insulin on metabolism and mammalian longevity | Autophagy And Protein Homeostasis; Extra-Pancreatic Insulin In The Brain; Healthy Aging; Hormonal And Neuronal Control Of Longevity; Insulin As A Tissue Growth Factor; Insulin Resistance And Glucose Homeostasis; Knockout Mouse Models; Mechanisms Of Aging And Longevity; Regulation Of Adipogenesis By Insulin; Regulation Of Lifespan By Diet And Caloric Restriction |
| Johnson, James D | University of British Columbia | Project Grant | Regulation of beta-cell proliferation by insulin production workload | Cell Differentiation; Cell Proliferation; Conditional Knockout Mice; Diabetes; Endoplasmic Reticulum Stress; Insulin Synthesis; Lineage Tracing; Pancreatic Beta-Cells; Proteomics; Transcriptomics |
| Johnson, Jeffrey A | University of Alberta | Operating Grant | Diabetes, influenza, and cardiopulmonary outcomes: The rationale for targeting influenza vaccinations for patients with diabetes | Diabetes; Influenza Vaccination; Influenza-Like Illness; Seasonal Influenza |
| Johnson, Jeffrey A | University of Alberta | Operating Grant | Cancer incidence and glucose lowering therapies for Type 2 Diabetes: Are there differences between agents? | Cancer; Epidemiology; Insulin; Metabolic Syndrome; Oral Hypoglycemic Agents; Type 2 Diabetes |
| Joseph, Jamie W | University of Waterloo (Ontario) | Project Grant | Role of prolyl hydroxylase in the regulation of insulin release. | Beta Cells; Insulin Secretion; Islets; Metabolism; Metabolomics; Oxygen Sensing; Pancreas; Transgenic Mice |
| Joseph, Jamie W | University of Waterloo (Ontario) | Operating Grant | The role of anaplerosis in glucose-stimulated insulin release. | Diabetes; Insulin Secretion; Islet Function; Metabolism; Molecular Biology; Pancreatic Beta-Cell |
| Jung, Mary E | University of British Columbia | Operating Grant | Integrating a brief, social cognitive theory-based intervention with high-intensity interval training to improve exercise adherence | Accelerometer; Behavioural Counseling; Exercise Adherence; Prediabetes; Self-Efficacy; Self-Regulation; Social Cognitive Theory |
| Jung, Mary E | University of British Columbia | Foundation Grant | Self-Regulation of Exercise Behaviour in Individuals with Prediabetes: From Evidence to Community Implementation | Community Intervention; Continuous Glucose Monitors; Evidence-Based Behaviour Change Techniques; Exercise Adherence; Mobile Health; Prediabetes; Self-Monitoring; Self-Regulation; Self-Regulatory Skills |
| Kaartinen, Mari T | McGill University/Université McGill | Project Grant | Role of factor XIII-A and plasma fibronectin in etiology of obesity and type 2 diabetes. | Adipogenesis; Extracellular Matrix; Factor XIII-A; Fat Tissue; Fibronectin; Fibrosis; Insulin Resistance; Obesity; Transglutaminase; Type 2 Diabetes |
| Kaplan, David R | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Establishment and maintenance of adult neural stem cell pools | Autism; Brain Aging; Brain Development; Growth Factor; Maternal Diabetes; Maternal Infection; Neural Stem Cell; Proteomics; Senescence; Transgenic Mice |
| Kaplan, Gilaad G | University of Calgary | Operating Grant | Preventing Myocardial Infarctions with the Air Quality Health Index | Air Pollution; Air Quality Health Index; Diabetes; Myocardial Infarction |
| Katz, Sherri L | Children's Hospital of Eastern Ontario Research Institute Inc/Institut recherche Centre hospitalier pour enfants de l'est de l'Ontario University of Ottawa/Université d'Ottawa |
Sleep and Circadian Rhythms: Operating Grant | Does Treating Obstructive Sleep Apnea in Obese Canadian Youth Improve Blood Sugar Control? A Multi-Centre Prospective Cohort Study. | Cohort Study; Insulin Resistance; Non-Invasive Ventilation; Obesity; Obstructive Sleep Apnea; Pediatric |
| Kaul, Padmaja R | University of Alberta | Operating Grant | Gestational Diabetes Mellitus in Alberta | Diagnosis; Gestational Diabetes Mellitus; Pregnancy And Birth Cohort; Rural Urban Differences |
| Kaul, Padmaja R | University of Alberta | Project Grant | Impact of maternal diabetes status on adverse neonatal and early childhood outcomes | Early Childhood Outcomes; Maternal Health; Newborn Health; Pregnancy |
| Kaul, Padmaja R | University of Alberta | Operating Grant - Secondary Analysis of Databases | Long-term health outcomes of mothers with gestational diabetes mellitus and their children in Alberta | Child'S Health; Gestational Diabetes Mellitus; Women's Health |
| Kauppinen, Tiina | University of Manitoba | Project Grant | Microglia and cognitive impairments in offspring exposed to gestational diabetes mellitus | Cognitive Functions; Conditional Knock Out Mice; Fetal Programming; Gestational Diabetes Mellitus; Hippocampus; Lentivirus Transduction; Microglia; Neurodevelopment; Neuroinflammation; Synapse |
| Kazak, Lawrence | McGill University/Université McGill | Project Grant | Physiology and mechanisms of adipocyte creatine energetics | Adipose Tissue; Brown Fat; Ckb; Creatine; Energy Expenditure; Metabolomics; Mitochondria; Mouse Models; Obesity; Thermogenesis |
| Kennedy, Christopher R | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Prostanoid Signaling in Diabetic Nephropathy | Cell Signaling; Diabetic Nephropathy; Gene-Targeted Mice; Podocyte; Prostanoid Receptors; Proteinuria |
| Kennedy, Christopher R | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Validating Nox5 as a target for diabetic renal complications | Diabetes; Kidney; Podocyte; Reactive Oxygen Species; Transgenic Mice |
| Kenny, Glen P | University of Ottawa/Université d'Ottawa | Operating Grant | Heat stress in older adults and individuals with type 2 diabetes | Aging; Body Heat Storage; Diabetes; Exercise; Heat Stress; Metabolism; Physical Activity; Skin Blood Flow; Sweating; Thermoregulation |
| Khan, Nadia A | St. Paul's Hospital, Vancouver University of British Columbia |
Operating Grant | A Culturally Tailored Intervention to Improve Management of Type 2 Diabetes Mellitus in South Asian Patients | A1c; Cultural Barriers; Diabetes; Ethnicity; Peer Intervention; South Asian |
| Khan, Nadia A | St. Paul's Hospital, Vancouver University of British Columbia |
Operating Grant | Ethnocultural differences in adherence to pharmacotherapy among Chinese, South Asian and White adults with Type 2 diabetes | Adherence; Administrative Data; Diabetes; Ethnicity |
| Kieffer, Timothy J | University of British Columbia | Foundation Grant | Hormonal Regulation of Glucose Homeostasis | Beta-Cells; Development; Diabetes; Fgf21; Incretins; Insulin; Islet; Leptin; Obesity; Stem Cells |
| Kieffer, Timothy J | University of British Columbia | Emerging Team Grant: Regenerative Medicine and Nanomedicine | Generation of Transplantable Beta-Cells from Human ES Cells | Diabetes; High-Content Imaging; Microrna; Stem Cells; Transcription Factors; Transplant |
| Kieffer, Timothy J | University of British Columbia | Operating Grant | Effects of early overnutrition on beta-cell function | Beta-Cell; Diabetes; Leptin; Nutrition; Obesity; Postnatal Development |
| Kieffer, Timothy J | University of British Columbia | Operating Grant | Leptin Regulation of Glucose Homeostasis | Diabetes; Glucose; Insulin; Islet; Leptin; Transgenic |
| Kienesberger, Petra C | Dalhousie University (Nova Scotia) | Project Grant | Autotaxin-lysophosphatidic acid signaling in obesity-related heart disease | Cardiomyocyte; Cardiomyopathy; Cell Signaling; Diabetes; Energy Metabolism; Heart Disease; Insulin; Lipids; Mitochondria; Obesity |
| Kimmins, Sarah | McGill University/Université McGill | Operating Grant | Obesity and nutritional programming of the paternal sperm epigenome: effects on offspring development and health | Developmental Origins of Adult Disease; Dietary Folate; Environmental Programming; Epigenomics; Histones; Paternal Disease Transmission; Paternal Obesity; Reproduction; Spermatogenesis; Transgenerational Inheritance |
| King-Jones, Kirst | University of Alberta | Operating Grant | Analysis of regulatory networks controlling cholesterol and lipid metabolism in Drosophila | Cholesterol And Lipid Metabolism; Gene Expression Profiling; Genome Wide Dna-Binding (Chip); Mutant Analysis; Nuclear Receptor; Target Gene Discovery |
| Klein, Doug | University of Alberta | Operating Grant - PA: INMD Start-up Funds (Clinicians and New Investigators) | An evaluation of the CHANGE lifestyle intervention in primary care: a multicenter cluster randomized trial | Effectiveness; Exercise; Family Medicine; Lifestyle Intervention; Metabolic Syndrome; Nutrition; Primary Care; Randomized Control Trial |
| Klein, Doug | University of Alberta | Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | An evaluation of the CHANGE lifestyle intervention in primary care: a multicenter cluster randomized trial | Effectiveness; Exercise; Family Medicine; Lifestyle Intervention; Metabolic Syndrome; Nutrition; Primary Care; Randomized Control Trial |
| Klip, Amira | Hospital for Sick Children (Toronto) University of Toronto |
Foundation Grant | Cell biology and physiology of muscle insulin delivery, insulin action and insulin resistance leading to diabetes | Cell-Cell Communication; Glucose Transporters; Insulin Action And Signalling; Insulin Transcytosis; Lipotoxicity; Macrophage Activation; Microvascular Endothelium; Muscle Insulin Resistance; Obesity-Induced Inflammation; Vesicle Traffic |
| Klip, Amira | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Regulation of muscle glucose transporters by Rac and Rabs during insulin action and lipotoxicity | Actin Remodelling; Glucose Transporters; Insulin Action And Signalling; Intracellular Compartments; Muscle Cells; Vesicle Traffic |
| Klip, Amira | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Macrophage lipotoxic inflammation: Its mechanism, impact on insulin delivery and interplay with muscle | Cell-Cell Communication; Insulin Transcytosis; Lipotoxicity; Macrophage Activation; Microvascular Endothelium; Muscle Insulin Resistance; Obesity-Induced Inflammation; Vesicular Traffic |
| Knauper, Barbel | McGill University/Université McGill | Project Grant | Increasing the long-term effectiveness of behavioral weight loss programs for emotional eaters through the habitual use of acceptance-based strategies | Acceptance And Commitment Therapy; Behavioral Weight Loss Program; Emotion Regulation Skills; Emotional Eating; Habit Formation; If-Then Planning; Implementation Intentions; Lifestyle Modification Programs; Overweight And Obesity; Randomized Controlled Trial |
| Knauper, Barbel | McGill University/Université McGill | Project Grant | Increasing the effectiveness of weight loss programs for emotional eaters: Training emotional eaters to use acceptance-based techniques for weight loss and maintenance | Acceptance And Commitment Therapy; Behavioural Weight Loss Programs; Emotion Regulation Skills; Emotional Eating; Habit Formation; If-Then Planning; Lifestyle Modification Program; Overweight And Obesity; Physical Activity; Randomized Controlled Trial |
| Knauper, Barbel | McGill University/Université McGill | Operating Grant | Increasing the Effectiveness of the Diabetes Prevention Program Through If-then Plans and Mental Practice: A Parallel Randomized Trial | Diabetes Prevention; Habit Formation; Implementation Intentions; Lifestyle Modification Program; Mental Practice; Physical Activity; Program Effectiveness; Weight Loss |
| Kokoeva, Maia | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Adult neurogenesis and the central control of energy homeostasis | Adult Neurogenesis; Body Weight Set Point; Central Control Of Energy Homeostasis; Diet-Induced Obesity; Electron Microscopy; High Caloric Diet; Hypothalamus; Icv Surgery; Immunohistochemistry; Mouse Model; Neural Plasticity; Neuroendocrinology; Obesity; Type 2 Diabetes |
| Kokoeva, Maia | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGillMcGill University/Université McGill | Project Grant | Anatomy of leptin sensing | Arcuate Nucleus; Hypothalamus; Leptin Receptor; Leptin Resistance; Median Eminence; Neurobiology Of Energy Homeostasis; Neurobiology Of Obesity |
| Koromilas, Antonis E | Lady Davis Institute for Medical Research (Mtl) McGill University/Université McGill |
Operating Grant | Functional interactions between PI3K-Akt and eIF2alpha phosphorylation pathways: Implications in cell signaling and tumor treatment. | Apoptosis; Chemotherapeutic Drugs; Eif2alpha Phosphorylation; Endoplasmic Reticulum Stress; Mrna Translation; Oxidative Stress; Pi3k-Akt Pathway; Protein Phosphorylation; Tumorigenesis; Xenograft Tumor Assays |
| Kramer, Caroline K | Sinai Health System (Toronto) University of Toronto |
Project Grant | Metabolic impact of intermittent fasting in early type 2 diabetes | Blood Pressure; Body Weight; Glycated Hemoglobin; Insulin Sensitivity; Intermittent Fasting; Obesity; Pancreatic Beta-Cell Function; Time Restricted Feeding; Type 2 Diabetes |
| Kramer, Caroline K | Sinai Health System (Toronto) University of Toronto |
Project Grant | Empagliflozin and the Preservation of Pancreatic Beta-Cell Function in Women with Recent Gestational Diabetes | Beta-Cell Function; Clinical Trial; Empagliflozin; Gestational Diabetes; Postpartum; Pre-Diabetes; Prevention; Sglt-2; Type 2 Diabetes |
| Kramer, Caroline K | Sinai Health System (Toronto) University of Toronto |
Project Grant | Empagliflozin and the Preservation of Pancreatic Beta-Cell Function in Women with Recent Gestational Diabetes | Beta-Cell Function; Clinical Trial; Gestational Diabetes; Post-Partum; Pre-Diabetes; Prevention; Sglt-2; Type 2 Diabetes |
| Krause, Henry M | University of Toronto | Operating Grant: CQDM/CIHR Collab Prog in Personalized Medicine -full appl | Zebrafish HTS platforms for nuclear receptor related drug discovery and pathway elucidation | Drug Discovery; Epigenetics; Nuclear Receptor; Transcriptome; Zebrafish |
| Krepinsky, Joan | McMaster University | Project Grant | The Role of Cell Surface GRP78 in the Pathogenesis of Diabetic Nephropathy | Animal Studies; Cell Signaling; Diabetic Nephropathy; Extracellular Matrix; High Glucose; Mesangial Cell; Protein Interaction Analysis; Rna Analysis; Transfection; Transforming Growth Factor Beta |
| Krepinsky, Joan | McMaster University | Project Grant | Role of miR-299a in regulating diabetic kidney disease | Animal Studies; Cell Signaling; Diabetic Kidney Disease; Extracellular Matrix; Fibrosis; Mesangial Cell; Micro Rna; Molecular Biology Methods |
| Krepinsky, Joan | McMaster University | Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | The Role of ADAM17 in the Pathogenesis of Diabetic Nephropathy | Animal Studies; Diabetic Nephropathy; Extracellular Matrix; Mesangial Cell; Signaling; Transfection |
| Krepinsky, Joan | McMaster University | Operating Grant | Does follistatin protect against diabetic nephropathy? | Activin A; Animal Studies; Diabetic Nephropathy; Extracellular Matrix; Mesangial Cell; Promoter Anlysis; Rna Analysis; Signaling; Transfection; Transforming Growth Factor Beta |
| Kuk, Jennifer Linche | York University (Toronto, Ontario) | Operating Grant-PA: INMD Start Up Funds (bridge funding) - New Investigators | Causes and Implications of Metabolically Healthy Obese | Cardiovascular Disease; Clinical Weight Management; Diabetes; Epidemiology; Metabolic Syndrome; Obesity; Population Health; Weight Loss |
| Kurtz, Donna L | University of British Columbia | Operating Grant: Pathways IRT – Component 1 – Diabetes/Obesity | Embracing A Vision for Indigenous Health: Community Access to Prevention, Self-management and Integrated Diabetes Services in the BC Interior | Community Based Participatory Research; Health Promotion; Indigenous Methodologies And Methods; Integrated Indigenous Diabetes/Obesity Services; Interdisciplianry Multi-Sector Team Development; Rural And Remote Aborigional Populations; Urban |
| Kurtz, Donna L | University of British Columbia | Project Grant | Building Indigenous Pathways for Diabetes and Obesity Prevention and Management with Urban and Rural Communities in BC | Cultural Safety; Diabetes And Obesity; Implementation Science; Indigenous Community Led; Traditional And Western Knowledge Service Delivery; Urban Indigenous Health |
| L'Abbe, Mary R | University of Toronto | Operating Grant | Food EPI - Assessing the food policy environment in Canada | Chronic Disease Prevention; Food Environment; Food Policy; Obesity; Population Health; Public Sector Policies |
| L'Abbe, Mary R | University of Toronto | Project Grant | The IMPACT of food environment policies on the Canadian food supply, dietary intakes and health: evidence to inform policy action | Cchs Dietary Intake; Food Environment; Menu Labelling; Nutrient Databases; Nutrient Profiling; Nutrition; Nutrition And Diet Modelling; Nutrition Policy; Sodium Reduction |
| Labbe, Aurelie | McGill University/Université McGill | Operating Grant | Redefining the phenotype in complex diseases through latent classes to model intra- and inter-family heterogeneity: application to genetic linkage and association analysis. | Gene Expression Data; Genetic Basis Of Complex Diseases; Genetic Heterogeneity; Genetic Linkage Analysis; Latent Class Analysis; Multivariate Phenotypes |
| Lacaille, Diane V | Arthritis Research Centre of Canada (British Columbia) | Operating Grant | Assessing the care for rheumatoid arthritis at a population level | Administrative Health Data; Arthritis; Epidemiology |
| Lam, Tony K | University Health Network (Toronto) University of Toronto |
Operating Grant | Nutrient sensing in the Gut | Diabetes/Obesity; Food Intake; Glucose Metabolism; Gut Nutrient Sensing; Gut/Brain/Liver Axis; Pancreatic Clamp / Intestinal Administration In Vivo |
| Lam, Tony K | University Health Network (Toronto) University of Toronto |
Foundation Grant | Metabolic Impact of Nutrient Sensing-dependent Neuronal Mechanisms in the Gut and the Brain | Bariatric Surgery / Metformin; Diabetes / Obesity; Duodenum / Jejunum / Ileum; Glucose / Lipid / Energy Homeostasis; Glucose Clamp / Ivgtt / Vldl-Tg / Energy Expenditure; Gut Microbiota; Gut-Brain-Liver-Brown Fat Axes; Hypothalamus / Dorsal Vagal Complex; Nutrient Sensing; Opto/Chemo-Genetic Approaches |
| Lam, Tony K | University Health Network (Toronto) University of Toronto |
Operating Grant | CNS nutrient sensing and the regulation of lipid, glucose and energy homeostasis | Brain/Liver; Diabetes; Dorsal Vagal Complex; Food Intake; Glucose And Lipid Metabolism; High-Fat Feeding; Hypothalamus; Nutrient Sensing; Obesity; Pancreatic Insulin/Glucose Clamp |
| Laplante, Mathieu | Université Laval | Project Grant | Molecular mechanisms of adipose tissue development | Adipocyte; Adipogenesis; Adipose Tissue Development; Obesity |
| Laplante, Mathieu | Université Laval | Project Grant | Defining the role of DEPTOR in the regulation of brown adipose tissue development/function and evaluation of its impact on systemic metabolism | Adipogenesis; Brown Adipose Tissue; Cell Signaling; Lipid Metabolism; Obesity |
| Laplante, Mathieu | Institut universitaire de cardiologie et de pneumologie de Québec - ULaval Université Laval |
Operating Grant | Implication of DEPTOR in the regulation of glucose/lipid homeostasis | Adipogenesis; Glucocorticoids; Glucose And Lipid Homeostasis; Insulin Resistance; Insulin Signaling; Liver Metabolism; Metabolic Diseases; Mtor Signaling; Obesity; Transgenic Mouse Models |
| Larose, Louise | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Project Grant | Deciphering the role of the interaction of Nck1 and PERK in regulating pancreatic beta cell function and survival | Adaptor Protein Nck; Diabetes; Islet Transplantation; Pancreatic Beta Cells; Pancreatic Islets; Protein Kinase Perk; Unfolded Protein Response |
| Larose, Louise | McGill University/Université McGill | Operating Grant | Role of the Adaptor Protein Nck in the Pathogenesis of Insulin Resistance and Type 2 Diabetes | Adaptor Proteins; Diabetes; Endoplasmic Reticulum Stress; Glucose And Lipid Metabolism And Homeostasis; Hepatic Gluconeogenesis; Insulin Signaling And Resistance; Nck Knock Out Mice; Obesity; Primary Hepatocytes; Unfolded Protein Response |
| Lautt, W. Wayne | University of Manitoba | CIHR/Regional Partnership Program/Operating Grants | Mechanism of loss of vasodilation response to insulin in type 2 diabetes | Diabetes; Vascular Dysfunction |
| Lavoie, Josée G | University of Northern British Columbia | Operating Grant | Towards closing the gap: using evidence to identify the need for investments in primary health care services on BC First Nation reserves | Access; Ambulatory Care Sensitive Conditions; Equity; First Nations; Gee Modeling; Primary Health Care |
| Law, Michael R | University of British Columbia | Operating Grant | For Whom the Bill Tolls: Private Drug Insurance in Canada | Access To Care; Drug Use And Costs; Employer-Sponsored Health Benefits; Health Care Expenditure; Health Insurance; Pharmaceutical Policy; Policy Evaluation; Retiree Benefits |
| Lear, Scott A | St. Paul's Hospital, Vancouver University of British Columbia |
Operating Grant | Utility of a culturally relevant or a standard exercise program to reduce visceral adipose tissue and cardiovascular disease risk in abdominally obese South Asian women | Cardiovascular Disease Risk Factors; Exercise; Obesity; Post-Menopausal Women; South Asians; Visceral Adipose Tissue |
| Lee, Ping I | University of Toronto | Operating Grant | Novel Nitric Oxide Delivery System for Wound Healing | Critical Design Parameters Affecting No Delivery Properties; Enhanced Wound Healing In A Diabetic Animal Model; Mechanisms Of Nitric Oxide Release From The Present System; New Supramacromolecular Complexes For Extended Release Of No; Optimization Of Nitric Oxide Loading And Release; Study Of Various Physical Forms Of The Present Complexes |
| Lega, Iliana C | Women's College Research Institute (Toronto, Ontario) | Project Grant | The prevalence and impact of intensive diabetes treatment in older adults | Diabetes; Management; Older Adults; Overtreatment; Population-Based |
| Lehner, Richard | University of Alberta | Operating Grant | Role of Es-x in lipid metabolism | Atherosclerosis; Fatty Liver; Genetic Engineering; Lipase; Lipoprotein Secretion; Obesity; Type 2 Diabetes |
| Lehner, Richard | University of Alberta | Operating Grant | Molecular characterization of esterase Es-x | Atherosclerosis; Genetic Engineering; Lipolysis; Nafld; Type 2 Diabetes; Vldl Secretion |
| Lehner, Richard | University of Alberta | Project Grant | Metabolic role of arylacetamide deacetylase (AADAC) | Cholesterol; Flutamide Metabolism; Gene Expression; Knockout Mice; Lipase; Lipid Metabolism; Lipidomics; Lipoproteins; Liver And Intestine; Triglycerides |
| Lehner, Richard | University of Alberta | Project Grant | Role of a lipid hydrolase TGH in hepatic fat storage and lipoprotein secretion | Fatty Liver Disease; Insulin Resistance; Intestine; Knockout Mice; Lipase; Lipid Droplets; Lipid Metabolism; Lipoproteins; Liver; Obesity |
| Lehner, Richard | University of Alberta | Operating Grant | Role of triacylglycerol hydrolase in lipid metabolism | Atherosclerosis; Lipolysis; Lipoproteins; Nafld; Type 2 Diabetes |
| Lemieux, Joanne M | University of Alberta | Operating Grant | Insights into the molecular mechanism of rhomboid intramembrane peptidases | Enzymology; Intramembrane Peptidase; Membrane Protein Biochemistry; Saxs; X-Ray Crystallography |
| Leroux, Michel R | Simon Fraser University (Burnaby, B.C.) | Operating Grant | Dissecting the molecular and cellular links between cilia, cGMP signaling, physiology and disease | Bardet-Biedl Syndrome; Cgmp Signaling; Cilia; Disease; Satiety/Obesity; Sensory Perception |
| Lévesque, Lucie | Queen's University (Kingston, Ontario) | Operating Grant: Population Health Intervention Research | Dissemination of 'Pausa Activa', a strategy to enhance physical activity promotion in health care settings in Mexico: Investigating program implementation and impact | Physical Activity Promotion; Physician Training; Primary Health Care |
| Levine, Joel D | University of Toronto | Operating Grant | The neurogenetic basis of group dynamics in Drosophila | Behavioural Genetics |
| Levings, Megan K | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | Molecular and cellular biology of T regulatory cells | T Cell Signalling; T Regulatory Cells; Tolerance |
| Levitan, Robert D | Centre for Addiction and Mental Health (Toronto)/Centre de toxicomanie et de santé mentale University of Toronto |
Operating Grant | An Early Developmental Model of Overeating, Obesity and Executive Dysfunction | Attention Deficit; Dopamine; Executive Function; Fetal Adversity; Food Reward; Genes; Impulsivity; Obesity |
| Lewis, Gary F | University Health Network (Toronto) University of Toronto |
Operating Grant | Regulation of intestinal and hepatic lipoprotein particle secretion in humans | Fat; Glp-1; Glp-2; Human; Intestine; Lipoprotein Metabolism; Resveratrol; Stable Isotopes |
| Lewis, Gary F | University of Toronto | Project Grant | Novel Aspects of the regulation of intestinal lipoprotein particle secretion in humans | Apolipoprotein; Diabetes; Insulin Resistance; Intestine; Lipoprotein; Liver |
| Libman, Eva | CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General/CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Hôpital juif McGill University/Université McGill |
Operating Grant | Daytime functioning and sleep disorders in older adults: Predicting sleep apnea in a prospective primary care study | Aging; Case Identification; Health Risks; Polysomnography; Primary Care; Sleep Apnea; Symptoms |
| Light, Peter E | University of Alberta | Project Grant | Novel protective roles for ATP-sensitive potassium channels in the heart | Electrophysiology; Heart; Heart Failure; Ischemic Heart Disease; Katp Channels; Metabolism; Sulfonylureas |
| Light, Peter E | University of Alberta | Operating Grant | Novel protective roles for ATP-sensitive potassium channels in the heart | Amp Activated Kinase; Atp-Sensitive Potassium Channel; Cardioprotection; Electrophysiology; Ion Channels; Ionic Homeostasis; Ischemia Reperfusion Injury; Patch-Clamp |
| Light, Peter E | University of Alberta | Project Grant | Characterization of a novel light-sensitve signalling pathway in subcutaneous human adipocytes | Adipocytes; Adipokines; Diabetes; Melanopsin; Obesity; Trpc Channels |
| Light, Peter E | University of Alberta | Operating Grant | ATP-sensitive potassium channels: common variants, pharmacogenomics and type 2 diabetes risk | Atp-Sensitive Potassium Channels; Beta-Cell; Common Genetic Variants; Metabolism; Patch-Clamp; Type 2 Diabetes |
| Lim, Gareth E | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Project Grant | Targeting molecular scaffolds for the treatment of obesity and metabolic disease | 14-3-3; Adipocyte; Adipogenesis; Differentiation; Metabolism; Obesity; Progenitor; Proteomics; Scaffold |
| Lima, Viviane D | University of British Columbia | Project Grant | The Health and Economic Forecasting Micro-Simulation Model: A tool to evaluate future health policies and programmatic interventions targeting the aging population living with HIV in British Columbia | Aging; Comorbidities; Forecasting; Healthcare Expenditure; Healthcare Utilization; Hiv; Intervention; Micro-Simulation Model; Mortality; Quality Of Life |
| Lipscombe, Lorraine | Women's College Hospital (Toronto) University of Toronto |
Project Grant | Avoiding diabetes after pregnancy trial in moms (ADAPT-M) | Diabetes Education; Diabetes Prevention; Gestational Diabetes; Lifestyle Intervention |
| Lipscombe, Lorraine | Women's College Hospital (Toronto) University of Toronto |
Operating Grant | The Influence of Diabetes on Cancer Screening and Prognosis | Cancer; Cancer Screening; Diabetes; Health Services |
| Lisonkova, Sarka | University of British Columbia | Operating Grant: NI grants in MRC&Y Health – Nutrition, Metabolism and Diabetes | Improving maternal and perinatal outcomes in high risk mothers | Maternal Health; Perinatal Epidemiology |
| Lix, Lisa M | University of Saskatchewan | Operating Grant | Completeness of Physician Billing Claims Administrative Health Databases in Canada | Administrative Health Databases; Chronic Disease; Completeness; Data Quality; Pan-Canadian Study; Prevalence |
| Loewen, Christopher | University of British Columbia | Operating Grant | Endoplasmic reticulum membrane contact sites: role in ER polarization, lipid metabolism and protein trafficking | Amyotrophic Lateral Sclerosis (Als); Endoplasmic Reticulum; Lipid Metabolism; Lipid Transfer Protein; Membrane Contact Sites; Nonvesicular Traffic |
| Lopaschuk, Gary D | University of Alberta | Project Grant | Branched Chain Amino Acid Contribution to Cardiac Insulin Resistance in Heart Failure | Branched Chain Amino Acids; Fatty Acid Oxidation; Glucose Oxidation; Heart Failure; Insulin Resistance; Mtor; Obesity |
| Lopaschuk, Gary D | University of Alberta | Foundation Grant | Optimizing cardiac energy metabolism to treat heart disease | Energy Metabolism; Fatty Acid Oxidation; Glucose Oxidation; Heart; Heart Failure; Ischemic Heart Disease; Ketone Oxidation; Mitochondria |
| Lopaschuk, Gary D | University of Alberta | Project Grant | The metabolic basis if heart failure in diabetes and obesity | Acetylation; Diabetes; Fatty Acid Oxidation; Glucose Oxidation; Heart Failure; Hypertrophy; Insulin Resistance; Mitochondria; Mtor; Obesity |
| Luciani, Dan S | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | Control of beta-cell mitochondrial physiology and adaptation by core anti-apoptosis proteins | Apoptosis; Autophagy; Diabetes; High Fat Diet; In Vivo Glucose Homeostasis; Islet Biology; Knockout Mouse Models; Live Cell Microscopy; Metabolic Stress; Mitochondrial Physiology |
| Luciani, Dan S | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | Control of beta-cell mitochondrial physiology by core anti-apoptosis proteins | Apoptosis; Diabetes; In Vivo Glucose Homeostasis; Islet Biology; Knockout Mouse Models; Live Cell Microscopy; Metabolic Stress; Mitochondrial Physiology |
| Luheshi, Giamal N | CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Douglas Hospital/CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Hôpital Douglas McGill University/Université McGill |
Operating Grant | The effects of obesity on the immune response to infection: mechanisms and sites of action | Adipokines; Fever; Immune Response; Immunoassays; Infection/Inflammation; Obesity |
| Luo, Zhong-Cheng | Université de Montréal | Operating Grant | Quebec Administrative health databases linkage-based study on First Nations and Inuit birth and infant outcomes | Aboriginal Maternal And Infant Health; Administrative Health Database Linkage; Gestational Diabetes; Gestational Hypertension; Infant Mortality; Macrosomia; Perinatal Epidemiology; Perinatal Mortality; Preterm Birth |
| Lye, Stephen J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Gene-environment interactions underlying the developmental origins of health and disease | Developmental Origins Of Health And Disease; Gene-Environment Interactions; Hypothalamic-Pituitary-Adrenal Axis; Metabolic Syndrome; Pregnancy Complications |
| Lye, Stephen J | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | A Murine Model to Investigate the Mechanisms Underlying DOHaD | Developmental Health; Developmental Origins Of Health And Disease; Fetal Growth And Development; Metabolic Syndrome; Pregnancy |
| Lynn, Francis C | University of British Columbia | Operating Grant | Post-transcriptional control of Sox9 during endocrine pancreas development: role of microRNAs | Development; Diabetes; Human Embryonic Stem Cells; Microrna; Sox9; Transcription Factor |
| Lynn, Francis C | BC Children's Hospital Research Institute University of British Columbia |
Project Grant | Cell cycle regulation of human pancreatic endocrine cell development | Cell Cycle; Diabetes; Differentiation; Endocrine Cells; Genome Editing; Human Embryonic Stem Cells; Insulin; Neurog3; Pancreas; Transcription Factors |
| Lynn, Francis C | University of British Columbia | Operating Grant | Npas4 Regulation of Glucose Homeostasis | Bhlh-Pas; Endoplasmic Reticulum Stress; Gene Transcription; Glucolipodysfunction; Impaired Glucose Tolerance; Insulin Gene Expression; Insulin Secretion; Obesity; Type 2 Diabetes; ß-Cell Biology |
| Lytton, Jonathan | University of Calgary | Project Grant | Obesity, Diabetes & Eating Disorders: The role of Calcium Signaling and the Calcium Transporter, NCKX4 | Calcium Signalling; Diabetes; Membrane Transport; Molecular Biology; Obesity; Sodium-Calcium Exchange |
| MacDonald, Patrick E | University of Alberta | Foundation Grant | The pancreatic islet in human health and diabetes | Biobank; Cell Physiology; Diabetes; Exocytosis; Insulin; Ion Channels; Islets Of Langerhans; Metabolism; Patch-Clamp; Secretion |
| MacDonald, Patrick E | University of Alberta | Operating Grant | Novel roles for K+ channels in islet function and the pathophysiology of diabetes | Calcium; Cellular Imaging; Diabetes; Exocytosis; Human Cells; Insulin; Ion Channels; Islets Of Langerhans; Patch-Clamp; Secretion |
| MacDonald, Patrick E | University of Alberta | Operating Grant | Regulation of pancreatic beta-cell exocytosis and insulin secretion by SUMOylation | Excitosome; Exocytosis; Insulin; Ion Channels; Senp; Snare Proteins; Sumo; Ubc9 |
| MacDonald, Patrick E | University of Alberta | Operating Grant | Regulation of pancreatic beta-cell exocytosis and insulin secretion by SUMOylation | Excitosome; Exocytosis; Insulin; Ion Channels; Snare Proteins; Sumo |
| Macleod, Kathleen M | University of British Columbia | Operating Grant | Abnormalities of signaling pathways in diabetic cardiomyopathy: Implications for new treatment | Biochemical Analysis; Diabetic Cardiomyopathy; Heart Function; Mitochondria; Protein Kinase C; Rho Kinase |
| Maguire, Jonathon L | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant: SPOR Innovative Clinical Trial Multi-Year Grant | CoMFORT (Cow's Milk Fat Obesity pRevention Trial) | Epidemiology; Nutrition; Obesity; Pediatrics; Vitamin D |
| Mahmud, Farid | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant: SPOR & JDRF - ICT Multi-Year Grant | Adolescent Type 1 diabetes Treatment with EMPaglifozin for hyperglycemia & hyperfilTration Trial, "ATTEMPT" Trial | Adolescence; Cardiovascular Disease; Diabetes Mellitus; Diabetic Nephropathy; Hyperfiltration; Metabolic Control; Patient-Oriented Research; Randomized Controlled Trial |
| Mahon, Jeffrey L | University of Western Ontario | Randomized Controlled Trials | Trial to Reduce IDDM in the Genetically at Risk (TRIGR) | Avoidance Of Cow¿S Milk Protein In Diet; Complex And Family History Risk; Intervention To Prevent Diabetes Within 6-8 Mths Age; Major Histocompatibility; Newborns At High Risk For Diabetes Mellitus; Randomized Double-Blinded Control Trial |
| Mailhot, Geneviève | Centre hospitalier universitaire Sainte-Justine
Université de Montréal |
Operating Grant | Homéostasie intestinale de la vitamine D chez la fibrose kystique : Rôle du CFTR | Cftr; Culture Cellulaire; Fibrose Kystique; Malabsorption; Physiologie Intestinale; Vitamine D |
| Manns, Braden J | University of Calgary | Foundation Grant | Informing health care policy makers on health care financing and sustainability | Cost Sharing; Costing Studies; Economic Evaluation; Health Policy; Knowledge Translation; Medication Co-Payment; Pharmaceutical Policy; Randomized Trials |
| Manns, Braden J | University of Calgary | Partnerships for Health System Improvement (PHSI) | The Impact of Primary Care Networks on the Care and Outcome of Patients with Diabetes | Ambulatory Care Sensitive Conditions; Chronic Disease Management; Diabetes; Health Services Research; Outcomes; Primary Care Network |
| Manson, Heather | Ontario Agency for Health Protection and Promotion (Toronto, Ontario)/L'Agence ontarienne de protection et de promotion de la santé University of Toronto |
Operating Grant: Population Health Intervention Research - Pathways | Cultivating community partnerships to assess the impact of a population health intervention targeting Aboriginal children and youth for promoting healthy weights in Ontario | Aboriginal Peoples' Health; Indigenous Ways Of Knowing And Doing; Program Evaluation; Qualitative Methods |
| Manuel, Douglas G | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Project Grant | Measuring compression and expansion of morbidity from chronic diseases using a multivariable predictive approach | Morbidity; Mortality; Population Health |
| Marette, André | Université Laval | Operating Grant | Role of iNOS in the pathogenesis of insulin resistance | Adiponectin; Adipose Tissue; Ampk; Enos; Glucose Metabolism; Inos |
| Marette, André | Université Laval | Operating Grant | Metabolic functions of the PTPase SHP-1 in insulin target tissues | Adipose Tissue; Glucose Metabolism; Insulin Resistance; Insulin Signaling; Lipid Metabolism; Liver; Obesity; Protein Tyrosine Phosphatase; Skeletal Muscle; Steatosis |
| Marette, André | Université Laval | Operating Grant | Role of the mTOR/S6K1 and RSK pathways in the pathogenesis of insulin resistance | Adipose Tissue; Animal Models; Cell Culture; Diabetes; Glucose Transport; Insulin Resistance; Liver; Muscle; Nutrient Sensing |
| Marette, André | Université Laval | Operating Grant: Sugar and Health - Sugars and Health | Effect of free sugar replacement with non-nutritive sweeteners on metabolic health of high sugar sweetened beverages consumers: role of the gut microbiome | Diabetes; Gut Microbiota; Human Subjects; Metabolic Syndrome; Metabolism; Microbiome; Non-Nutritive Sweeteners; Nutrition; Sugar Sweetened Beverages; Sugars |
| Marette, André | Université Laval | Operating Grant | Metabolic functions of the PTPase SHP-1 in insulin target tissues | Adipose Tissue; Glucose Metabolism; Insulin Resistance; Insulin Signaling; Lipid Metabolism; Liver; Obesity; Protein Tyrosine Phosphatase; Skeletal Muscle; Steatosis |
| Marette, André | Université Laval | Operating Grant: Programmatic Grants in Food & Heallth-Basic Biomedical Science | Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients: from animal models to obese insulin-resistant subjects | Animal Models; Cardiovascular Disease; Fish Nutrients; Human Subjects; Insulin Resistance; Metabolomics; Nutrigenomics; Obesity; Type 2 Diabetes; Vitamin D |
| Marette, André | Université Laval | Operating Grant | Role of the mTOR/S6K1 pathway in the pathogenesis of insulin resistance | Adipose Tissue; Animal Models; Cell Culture; Diabetes; Glucose Transport; Insulin Resistance; Liver; Muscle; Nutrient Sensing |
| Marette, André | Université Laval | Operating Grant | Role of iNOS in the pathogenesis of insulin resistance | Adiponectin; Adipose Tissue; Ampk; Enos; Glucose Metabolism; Inos |
| Marette, André | Université Laval | Foundation Grant | Pathogenesis and treatment of obesity-linked inflammation, insulin resistance and cardiometabolic complications | Adipose Tissue; Cardiovascular Disease; Diabetes; Fatty Liver Disease; Genetic Models; High-Fat Diet; Inflammation; Liver; Obesity; Skeletal Muscle |
| Marliss, Errol B | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Mechanisms of insulin resistance of protein metabolism in human obesity | Insulin Resistance; Mass Spectrometry; Muscle Biopsies; Obesity; Protein Synthesis And Catabolism; Stable And Radioactive Isotope Studies |
| Marzban, Lucy | University of British Columbia | Operating Grant | Molecular mechanisms of islet amyloid mediated beta cell death | Adenoviral Transduction; Amyloid; Beta Cell; Histology; Islet Transplantation; Type 2 Diabetes |
| Marzban, Lucy | Vancouver Coastal Health Research Institute University of British Columbia |
Operating Grant | Molecular mechanisms of islet amyloid mediated beta cell death | Adenoviral Transduction; Animal Studies; Beta Cell Apoptosis; Beta Cell Function; Cell Culture; Histology; Insulin; Islet Amyloid; Islet Transplantation; Type 2 Diabetes |
| Masse, Louise C | University of British Columbia | Operating Grant | Household environmental framework pertaining to childhood obesity: Improving our measures of the familial environment | Childhood Obesity; Familial Environment; Item Bank; Nutrition; Physical Activity; Psychometric; Questionnaire Design; Validation |
| Mathieu, Patrick | Université Laval | Operating Grant | The role of ectonucleotidase in the calcification of the aortic valve | Calcific Aortic Valve Disease; Calcification; Diabetes; Ectonucleotidase; Hypertension; Insulin Resistance |
| Matsubara, Joanne A | University of British Columbia | Project Grant | Treating advanced retinal degeneration - rebuilding multiple co-dependent retinal layers with stem cells | Combined Rpe And Photoreceptor Graft; Rebuilding Multiple Lost Retinal Layers; Regenerative Ophthalmology; Retinal Degenerative Diseases; Stem-Cell- And Device-Based Therapy |
| McBrien, Kerry | University of Calgary | Operating Grant: SPOR Innovative Clinical Trial Multi-Year Grant | ENCOMPASS: ENhancing COMmunity health through Patient navigation, Advocacy and Social Support | Chronic Disease; Cluster-Randomized Controlled Trial; Community Health Workers; Implementation Science; Patient Navigation; Primary Health Care |
| McDonald, Sarah D | McMaster University | Operating Grant: Maternal and Child Health | Understanding why some women do not breastfeed | Breastfeeding; Hierarchical Modelling; Niday Database; Observational Studies; Predictor Variables |
| McDonald, Sarah D | McMaster University | Operating Grant | Understanding Excessive Pregnancy Weight Gain: A Consideration of Psychological and other Determinants as a Prelude to Developing Interventions | Excess Pregnancy Weight Gain; Knowledge Determinants; Lifestyle Determinants; Obesity; Physical Determinants; Psychological Constructs; Qualitative Research; Weight Trajectories |
| McDonald, Sarah D | McMaster University | Knowledge Synthesis Grant | Synthesizing the evidence on psychological determinants of pregnancy weight gain: A prerequisite to developing effective interventions | Gestational Weight Gain; Infant Weight; Maternal Health; Obesity; Psychologic Determinants; Weight Trajectories |
| McDonald, Sarah D | McMaster University | Knowledge Synthesis Grant | Synthesizing the best evidence for weight gain during pregnancy in obese women: were the national guidelines excessive? | Gestational Weight Gain; Guideline Revision; Infant Health; Infant Macrosomia; Maternal Health; Obesity; Weight Trajectories |
| McFarlane, Sarah | University of Calgary | Project Grant | Identification and testing of novel inhibitors of pathological eye angiogenesis | Angiogenesis; Cell Guidance; Development; Eye; Model Organism; Neuron; Photoreceptor; Retinopathy; Semaphorins; Zebrafish |
| Mcgavock, Jonathan M | University of Manitoba | Operating Grant | The Physical activity for OverWEight youth at Risk for type 2 diabetes (POWER) Trial | Childhood; Exercise; Insulin Sensitivity; Magnetic Resonance Spectroscopy; Obesity; Type 2 Diabetes |
| Mcgavock, Jonathan M | University of Manitoba | Project Grant | If you build it, will they come?...and live longer? | Built Environment; Cardiovascular Disease; Natural Experiment; Physical Activity; Population Health Intervention |
| Mcgavock, Jonathan M | University of Manitoba | Operating Grant - PA: Regional Partnership Program : Manitoba | Aboriginal Youth Mentorship Program for increasing Physical Activity in Youth in Northern Aboriginal Communities | Aboriginal; Childhood Obesity; Peer-Mentoring; Physical Activity; Self Efficacy; Type 2 Diabetes |
| Mcgavock, Jonathan M | University of Manitoba | Operating Grant | Aboriginal Youth Mentor Program | Community-Based Participatory Action; Mentorship; Obesity; Physical Activity; Type 2 Diabetes |
| Mcgavock, Jonathan M | University of Manitoba | Team Grant : Pathways Implementation Research Teams – Component 3 | Deepening the roots of living in a good way for Indigenous Children. The Indigenous Youth Mentorship Program | Child Well-Being; Implementation Science; Indigenous Health; Indigenous Knowledge; Peer-Led Interventions; Resilience; Type 2 Diabetes Prevention |
| McGrath, Jennifer J | Concordia University (Montreal, Quebec)/Université Concordia | Operating Grant | Sleep and Obesity in Children and Adolescents: Identifying Pathogenic Pathways | Adolescents; Ambulatory Monitoring; Child Health; Children; Metabolic Syndrome; Obesity; Psychophysiology; School; Sleep; Stress Response System |
| McGrath, Jennifer J | Concordia University (Montreal, Quebec)/Université Concordia | CIHR New Investigator | Sleep and Obesity in Children and Adolescents: Identifying Pathogenic Pathways | Childhood Obesity |
| Mcguire, John J | Memorial University of Newfoundland | Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador | Acute and chronic PAR2 activation in endothelial dysfunction | Blood Pressure Telemetry; Calcium Imaging; Cell-Cell Communication; Diabetes Complications; Endothelial Cells Dysfunction; Hypertension; In Vivo Pharmacology; Inflammation; Isolated Blood Vessels; Protease-Activated Receptors |
| Mcinnes, Natalia | McMaster University | Operating Grant - Priority Announcement: Bariatric Care (Bridge Funding) | Evaluation of the early effects of Roux-en-Y gastric bypass surgery combined with perioperative caloric restriction on hepatic fat in obese patients with type 2 diabetes as compared to caloric restriction alone | Bariatric Surgery; Fatty Liver; Randomized Controlled Trial; Type 2 Diabetes |
| McMaster, Christopher R | Dalhousie University (Nova Scotia) | Operating Grant - PA: Existing and Emerging Threats & Chronic Disease | A Novel Antibiotic Class to Treat Diabetic Ulcer Infections | Antibiotics; Diabetic Ulcer Infection; Drug Development; Pharmacology |
| McMaster, Christopher R | Dalhousie University (Nova Scotia) | Operating Grant | A Novel Antibiotic Class to Treat Diabetic Ulcer Infections | Antibiotics; Diabetic Ulcer Infection; Drug Development; Pharmacology |
| McMurtry, Michael S | University of Alberta | Operating Grant | Vascular Metabolism and Angiogenesis | Angiogenesis; Arteriogenesis; Endothelium; Hindlimb Ischemia; Metabolism; Mitochondria |
| Mcpherson, Amy | Holland Bloorview Kids Rehabilitation Hospital (Toronto) University of Toronto |
Knowledge Synthesis Grant | Talking with children and families about weight-related issues: A scoping review of best practices | Communication; Scoping Review; Weight Discussions; Weight Management |
| McPherson, Ruth | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Metabolic and genetic determinants of obesity and obesity-related phenotypes | Adipose Tissue; Candidate Genes; Gene Expression; Genetics; Genome Wide Association Studies; Insulin Sensitivity; Lipoproteins; Obesity; Oxidative Phosphorylation |
| Melichar, Heather | CIUSSS Est-de-l'Ile-de- Montréal-Maisonneuve Rosemont Université de Montréal |
Operating Grant | Determining cause and effect: dynamic T cell receptor signaling during thymic selection | Negative Selection; Organotypic Culture; Positive Selection; Regulatory T Cell; T Cell Receptor Signaling; Thymus; Tissue Restricted Antigens; Two-Photon Microscopy |
| Merali, Zulfiquar | University of Ottawa Institute of Mental Health Research/Institut de recherche en santé mentale de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Stress-reducing effects of palatable foods: brain mechanisms and implications for obesity | Anxiety; Bombesin-Like Peptides; Corticotropin-Releasing Factor; Ghrelin; Ingestive Behavior; Microdialysis; Neuropeptides; Obesity; Stress |
| Michaud, Véronique | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Effects of Type 2 Diabetes (T2D) on drug disposition and CYP450 activities; a special look at extra-hepatic metabolism | Cytochromes P450; Drug Analysis; Drug Metabolism; Lc-Ms/Ms; Molecular Biology; Pharmacogenetics; Pharmacokinetics; Phenotype; Type 2 Diabetes |
| Mills, Susan L | University of British Columbia | Knowledge Synthesis Grant | Realist Synthesis of Self-Management Interventions for Disadvantaged Populations with Chronic Conditions | Chronic Conditions; Disadvantaged Populations; Primary Care; Realist Synthesis; Self-Management Interventions |
| Mitchell, Grant A | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant | Lipolysis: Biochemical Genetics, Physiology and Molecular Circuitry | Biochemical Genetics; Lipases; Lipidology; Mouse Models; Obesity |
| Mitchell, Lesley G | University of Alberta | Operating Grant | Acquired abnormalities in the hemostatic system in obese children prone to Type 2 diabetes: Mechanisms and interventions for risk of cardiovascular disease | Animal Models; Blood Proteins; Cardiovascular Disease; Cell Signalling; Clinical Studies; Coagulation/Fibrinolytic Capacity; Gene Expression; Obesity; Pediatrics; Type 2 Diabetes |
| Mitton, Craig R | University of British Columbia | Operating Grant: Population Health Intervention Research | Evaluation of Vancouver Coastal Health's Second Generation Strategy for the Downtown Eastside (DTES): a population health intervention study | Health Policy Analysis; Population Health Intervention; Priority Setting And Resource Allocation; Program Evaluation |
| Mizuno, Tooru M | University of Manitoba | Operating Grant - PA: Regional Partnership Program : Manitoba | Regulation of lipid metabolism by xenin | Biological Rhythm; Gut Hormone; Hypothalamus; Leptin; Lipid Metabolism; Lipolysis; Obesity; Sympathetic Nervous System |
| Mizuno, Tooru M | University of Manitoba | CIHR/Regional Partnership Program/Operating Grants | Role of xenin in the regulation of energy balance | Central Nervous System; Food Intake; Gastrointestinal Peptide; Obesity |
| Moher, David | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Knowledge Synthesis Grant | Do sugar-sweetened beverages cause adverse health outcomes in adults? A systematic review | Adult; Cancer; Cardiovascular Disease; Chronic Disease; Diabetes; Metabolic Syndrome; Obesity; Sugar-Sweetened Beverage; Systematic Review |
| Moher, David | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Knowledge Synthesis Grant | Do sugar-sweetened beverages cause adverse health outcomes in children? A systematic review | Academic Achievement; Children; Chronic Disease; Diabetes; Dyslipidemia; Hypertension; Obesity; Pediatric; Sugar-Sweetened Beverage; Systematic Review |
| Mourtzakis, Marina | University of Waterloo (Ontario) | Operating Grant | Evaluation of nutrition and metabolism in breast cancer patients | Body Composition; Breast Cancer; Exercise; Lipid; Metabolism; Muscle; Nutrition; Obesity |
| Muckle, Gina | Université Laval | Operating Grant | Environmental Contaminants and Adolescent Development | Aboriginal Health; Adolescents Development And Health; Environmental Contaminants; Prenatal Exposure; Public Health |
| Mui, Alice L | Vancouver Coastal Health Research Institute University of British Columbia |
Project Grant | Mechanism underlying hyporesponsiveness to Interleukin-10 in Type II Diabetes | Ampk; Biomarker; Inflammation; Macrophage; Ship1 Inositol Phosphatase; Type 2 Diabetes |
| Mulvihill, Erin E | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Project Grant | Glucose Lowering in T2DM: Mechanism of Action of Dipeptidyl Peptidase 4 Inhibitors | Dipeptidyl Peptidase 4; Incretin Hormones; Insulin; Islets; Metabolism; Mouse Genetics; Type 2 Diabetes Mellitus |
| Munoz, Douglas P | Queen's University (Kingston, Ontario) | Operating Grant | Establishment of a primate model that exhibits Alzheimer's-like features to explore new preventative and therapeutic strategies | Alzheimer's Disease; Behavioural Phenotyping; Biomarkers; Executive Function; Frontal Cortex; Insulin Signalling; Memory Control; Saccadic Eye Movements |
| Murshed, Monzur | McGill University/Université McGill | Operating Grant | Molecular mechanisms underlying the vascular calcification phenotype in matrix gla protein-deficient mice | Arteriovenous Malformation; Blood Vessels; Bone Mineralization; Ectopic Calcification; Elastin; Extracellular Matrix; Genetics; Matrix Degrading Enzymes; Matrix Gla Protein; Transgenic And Knockout Models |
| Mutch, David M | University of Guelph | Operating Grant - PA: INMD Start-up Funds (Clinicians and New Investigators) | FADS2 modulates n-3 fatty acid regulation of adipose tissue inflammation | Adipokines; Adipose Tissue; Clinical Study; Eicosanoids; Fatty Acid Desaturase 2; Inflammation; Knock-Out Mouse Model; Microarray; N-3 Fatty Acids; Translational Research |
| Nagy, Andras | Sinai Health System (Toronto) University of Toronto |
Canada-Japan CEEHRC Teams in Epigenetics of Stem Cells | Directing Cellular Identity to Move Towards Progenitor Cell Therapies | Cell Based Therapy; Cell Therapy Safety; Disease Models; Duchenne Muscular Dystrophy; Epigenetics; Gene Correction; In Vitro Differentiation; Induced Pluripotent Stem Cells; Reprogramming; Rett Syndrome |
| Ng, Dominic S | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | The role of cholesterol in the modulation of ER stress and diabetogenesis | Diabetes Mellitus; Fatty Acids Metabolism; Gene Knockout Mice; High Density Lipoproteins; Obesity; Regulation Of Gene Expressions |
| Nuyt, Anne Monique | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant: Maternal and Child Health | Devenir obstétrical des femmes nées prématurément | Complication De Grossesse; Diabète Gestationnel; Hypertension Gravidique; Programmation Développementale; Prématurité; Prééclampsie |
| Nuyt, Anne Monique | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant | Risk of Chronic Diseases in Young Adults Born Preterm: Relationship with Inflammation and Oxidative Stress Biomarkers | Cardio Metabolic Disease; Chronic Health Disease; Clinical Study; Developmental Programing Of Adult Diseases; Inflammation; Oxidative Stress; Prematurity |
| Nykiforuk, Candace | University of Alberta | Operating Grant: Advancing Theoretical & Methodological Innovations in Hlth Res | Assessing Community Environments for Physical Activity and Healthy Eating: Development of Innovative Mixed-Methods Approaches for Utilizing Objective and Subjective Data | Built Environment; Community Health; Discriminant Function Analysis; Health Outcomes; Mixed Methods; Participatory Workshops |
| O'Loughlin, Jennifer L | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant - Secondary Analysis of Databases | Understanding the evolving Canadian public health landscape for chronic disease prevention: Critical longitudinal analyses of Public Health Organizational Capacity Study (PHOrCaSt) data | Chronic Disease Prevention; Epidemiology; Longitudinal Analyses; National Survey; Organizational Capacity; Organizational Research; Population Health; Preventive Health Services; Transfer Practices |
| O'Reilly, Daria J | McMaster University | Operating Grant | Development of an open source diabetes economic model | Chronic Disease Model; Decision Analytic Modelling; Diabetes; Economic Evaluation |
| Orellana, Arturo | York University (Toronto, Ontario) | Project Grant | Developing small molecules targeting LXRb for the treatment of glucocorticoid induced diabetes | Drug Discovery; Glucocorticoids; Lxrb; Medicinal Chemistry; Nuclear Receptors; Pharmacokinetics |
| Oudit, Gavin Y | University of Alberta | Operating Grant | Role of ACE2 in Heart Disease: Pathophysiology, Molecular Mechanisms and Therapeutics | Diabetes Mellitus; Echocardiography; Heart Failure; Knockout Mouse Model; Signaling |
| Packer, Tanya L | Dalhousie University (Nova Scotia) | Project Grant | Developing a Patient-Centred, Clinically Relevant Measure of Self-management for Individuals with Multiple Chronic Conditions | Chronic Disease Self-Management; Measurement; Multi-Morbidity; Patient Reported Outcomes |
| Padwal, Raj S | University of Alberta | Operating Grant | Outcome Assessment to Optimize Patient Selection for Bariatric Surgery (OASIS) | Access To Care; Bariatric Surgery; Diabetes; Health Economics; Health Services; Mortality; Obesity; Patient Selection; Quality Of Life; Triage |
| Palazzo, Alexander F | University of Toronto | Operating Grant | The role of RanBP2 and sumoylation in regulating the translation of secretory mRNAs | Acute Necrotizing Encephalopathy; Cytokines; Endoplasmic Reticulum; Mrna Translation; Secretion; Sumoylation |
| Pamidi, Sushmita | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Project Grant | Maternal sleep-disordered breathing during pregnancy and long-term health outcomes in children: the 3D pregnancy and birth cohort | Cardiometabolic; Child Health; Neurocognitive; Obesity; Pregnancy; Sleep Apnea |
| Pamidi, Sushmita | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | The Effect of Continuous Positive Airway Pressure (CPAP) Treatment on Glycemic Control in Gestational Diabetes: A Pilot Randomized-Controlled Trial | Continuous Positive Airway Pressure (Cpap); Gestational Diabetes; Glucose Control; Pregnancy; Sleep Apnea |
| Paradis, Hélène | Memorial University of Newfoundland | Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador | Tubedown signaling pathway as a therapeutic target for age-related retinopathies | Acetyltransferase; Age-Related Rethinopathies; Aging; Animal Model; Endothelium; Neovascularization; Permeability; Signaling Pathway; Transgenic; Treatment |
| Paré, Guillaume | McMaster University | Operating Grant: Industry-partnered Collaborative Research | Integration of clinical, biomarker, and genetic data for prediction of adverse outcomes in diabetes | Biomarkers; Cardiovascular Disease; Diabetes; Genetics; Kidney Disease; Risk Prediction |
| Parekh, Rulan S | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Long-Term Survival in Childhood Solid Organ Transplants | Cancer; Cardiovascular Disease; Children; Chronic Diseases; Chronic Kidney Disease; Diabetes; Transplant |
| Parker, Thomas G | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | The role of the calcium-binding protein, S100B, in cardiovascular disease | Calcium-Binding Proteins; Myocardial Infarction; Transgenic Mice |
| Parks, Robin J | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Regulation of innate immunity during development | Apoptosis; Development; Innate Immunity; Obesity; Type 2 Diabetes |
| Pastinen, Tomi | McGill University/Université McGill | Operating Grant | Map of cis-regulatory variants in human genome | Epigenetics; Functional Variation; Gene Annotation; Genomics; Human Gene Expression; Polymorphisms |
| Paterno, Gary D | Memorial University of Newfoundland | Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador | MIER1 alpha, a novel PPAR gamma co-regulator, and its role in adipogenesis | Adipocyte Function; Adipogenesis; Conditional Knockout Mice; Diabetes; Fat Metabolism; Gene Expression; Microarray; Ppar Gamma; Protein Interaction; Transcriptional Regulator |
| Pause, Arnim P | McGill University/Université McGill | Project Grant | Interplay of AMPK and mTOR pathways at the lysosome: starvation, nutrient availability and metabolic disease | Ampk; Flcn; Metabolic Syndrome; Mtor; Obesity; Phosphorylation; Tfeb |
| Peng, Tianqing | London Health Sciences Centre Res. Inc. (Ont.) University of Western Ontario |
Operating Grant | Transformation of normal to abnormal myocardium by diabetes mellitus: role of Rac1-mediated calpain activation | Calpain; Cardiomyopathy; Diabetes; Myocardial Function; Nadph Oxidase; Rac1 |
| Peng, Tianqing | London Health Sciences Centre Res. Inc. (Ont.) University of Western Ontario |
Operating Grant | Calpain activation and diabetic cardiomyopathy | Apoptosis; Atp Synthase; Calpain; Cardiomyocytes; Cardiomyopathy; Diabetes; Heart; Mitochondria; Reactive Oxygen Species |
| Pernet, Vincent E | Université Laval | Project Grant | Mechanisms of neuronal and vascular impairments in ischemic retinopathies | Diabetic Retinopathy; Ischemic Retinopathies; Neuronal Repair; Nogo-A; Proliferative Retinopathy; Vascular Regeneration |
| Persaud, Navindra | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant: SPOR Innovative Clinical Trial Multi-Year Grant | CLEAN Meds RCT: Carefully seLected and Easily Accessible at No charge Medications | Equitable Access To Medication; Pharmaceutical Access; Prescription Medication; Rct |
| Phillips, Stuart M | McMaster University | Operating Grant | Adjunctive nutritional strategies to overcome sarcopenic muscle loss in aging | Aging; Branched-Chain Amino Acids; Casein; Citrulline; Human; Milk Proteins; Protein Metabolism; Sarcopenia; Stable Isotope; Whey |
| Picard, Frédéric | Institut universitaire de cardiologie et de pneumologie de Québec - ULaval Université Laval |
Project Grant | Modulation and effects of IGFBP-2 on brown adipose tissue thermogenesis | Brown Adipose Tissue; Energy Expenditure; Gene Expression; Imaging Techniques; Insulin Sensitivity; Lipid Metabolism; Mice; Molecular Biology; Obesity; Thermogenesis |
| Picard, Frédéric | Institut universitaire de cardiologie et de pneumologie de Québec - ULaval Université Laval |
Operating Grant | Transcriptional control of adipose tissue by OcaB upon aging | Adipocytes; Adipose Tissue; Aging; Bone Marrow Transfer; Energy Metabolism; Gene Expression; Insulin Resistance; Lymphocytes B; Mice; Nuclear Cofactors |
| Planel, Emmanuel | Université Laval | Operating Grant | Impact of diabetes on tau pathogenesis in vivo | Alzheimer's Disease; Diabetes Mellitus; Tau Pathology; Transgenic Mouse Models |
| Ploeg, Jenny | McMaster University | Operating Grant: SPOR PIHCI Network: Programmatic Grants | ACHRU Community Partnership Program for Diabetes Self-Management for Older Adults - Canada | Community-Based Care; Diabetes; Multiple Chronic Conditions; Older Adults; Patient-Oriented Research; Patients With Complex Needs; Pragmatic Trial; Primary Care; Self-Management |
| Poirier, Paul | Institut de cardiologie de Québec | Operating Grant - Priority Announcement: Bariatric Care (Bridge Funding) | Impact of a 12-week structured training program on changes in body composition and insulin resistance after a biliopancreatic diversion with duodenal switch surgery in severe obesity | Bariatric Surgery; Body Composition; Exercise; Fat Mass; Insulin Resistance; Lean Mass |
| Poitout, Vincent | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Project Grant | HB-EGF as a central regulator of pancreatic beta-cell proliferation | G Protein-Coupled Receptors; Growth Factors; Islets Of Langerhans; Pancreatic Beta Cell; Proliferation; Type 2 Diabetes |
| Poitout, Vincent | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | The role of RGS16 in pancreatic beta-cell function | Beta-Cell Biology; G-Protein Coupled Receptors; Glucose Homeostasis; Insulin Secretion |
| Poitout, Vincent | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | The role of GPR40 in pancreatic beta-cell function | Diabetes; G-Protein Coupled Receptors; Gpr40; Insulin Secretion; Islets Of Langerhans |
| Poitout, Vincent | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Project Grant | Role and therapeutic potential of RGS16 in pancreatic beta cells | Beta-Cell Proliferation; G Protein-Coupled Receptors; Glucose Homeostasis; Insulin Secretion; Islet Of Langerhans; Pancreatic Beta-Cell |
| Poitout, Vincent | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Glucolipodysfunction of the pancreatic beta-cell | Diabetes; Glucolipotoxicity; Insulin Gene; Islets Of Langerhans |
| Polychronakos, Constantin | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Project Grant | Precision diagnostics in childhood diabetes; therapeutic implications | Diabetes; Dominant; Exome; Mendelian; Mody; Monogenic; Neonatal; Recessive |
| Power, Christopher | University of Alberta | Operating Grant: Innovative Biomedical and Clinical HIV/AIDS Research | Therapeutic effects of intranasal insulin on HIV-associated neurocognitive disorder | Biomarkers; Clinical Trial; Hiv-Associated Neurocognitive Disorder; Hiv/Aids; Intranasal Insulin |
| Prakash, Satya | McGill University/Université McGill | Operating Grant | Polymeric membrane lactobacillus formulation for use in type II diabetes | Diabetes Mellitus; Feruloyl Esterase; Microcpsule; Polymeric Membrane |
| Prentki, Marc | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Proof of Principle Program - Phase I | Validation of a glycerolipid/ free fatty acid cycling enzyme as a novel therapeutic target for type-2 diabetes | Drug Development; Insulin Secretion; Monoglyceride Lipase; Pancreatic Beta Cell; Type-2 Diabetes |
| Prentki, Marc | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Foundation Grant | Lipid metabolism, insulin secretion and energy homeostasis | Abhd6; Adipose Browning; Fuel Detoxification; Glycerol-3-Phosphatase; Glycerolipid/Free Fatty Acid Cycling; Insulin Secretion; Lipid Metabolism; Monoacylglycerol; Obesity; Pancreatic Beta Cell |
| Prentki, Marc | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Molecular Basis of Fuel Surfeit Detoxification in Pancreatic beta-Cells | Fuel Detoxification; Glucolipotoxicity; Glycerolipid/Free Fatty Acid Cycling; Lipid Metabolism; Lipolysis; Pancreatic Beta Cell |
| Prentki, Marc | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Glucose regulation of insulin secretion and metabolic enzymes' gene expression | Anaplerosis/ Cataplerosis; Glycerolipid/Free Fatty Acid Cycling; Insulin Secretion; Lipid Metabolism; Monoacylglycerol; Pancreatic Beta Cell |
| Proctor, Spencer D | University of Alberta | Project Grant | Efficacy of a novel idiotypic antibody to inhibit cholesterol retention in atherosclerotic vascular disease during insulin resistance and diabetes | Animal Models; Arterial Retention; Atherosclerosis; Chimeric Antibodies; Glycosaminoglycans; Human Derived Specimens; Idiotypic Antibodies; Remnant Lipoproteins |
| Punthakee, Zubin | McMaster University | Team Grant - India-Canada Collaborative Teams in Childhood Obesity Research | Overweight and obesity in Asian Indian children in India and Canada: multi-level determinants, functional consequences and novel mechanisms | Body Composition; Built Environment; Children And Youth; Cross-Sectional Study; Eating And Activity Behaviours; Family Environment; Indian Origin; Metabolic Effects; Obesity; Qualitative Studies |
| Qi, Dake | Memorial University of Newfoundland | Project Grant | Macrophage migration inhibitory factor (MIF), a novel factor regulates hyperphagia and obesity associated with atypical antipsychotics | Atyical Antipsychotics; Macrophage Migration Inhibitory Factor; Metabolic Dysfunction; Procytokine |
| Quaggin, Susan E | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Operating Grant | Factors that Protect the Vasculature in Diabetes | Angiopoietin; Cre-Loxp; Diabetic Nephropathy; Mtor; Retinopathy; Tie2; Transgenic Mice; Vegf |
| Rabi, Doreen M | University of Calgary | Operating Grant | A Mixed-Methods Human Factors Evaluation of Patient Heath Portals in Diabetes | Chronic Disease Management; Diabetes; Ehealth |
| Raboud, Janet M | University Health Network (Toronto) University of Toronto |
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream | Development and Validation of an Algorithm to Impute Missing Stop Dates of Antiretroviral Therapy Regimens | Algorithm; Antiretroviral Therapy; Hiv/Aids; Imputation |
| Ramanathan, Sheela | Université de Sherbrooke | Operating Grant | Regulation of obesity by inflammatory cytokines | Adipose Tissue; Chemokines; Chronic Inflammation; Interleukin-15; Macrophages; Mice; Obesity; Patients; T Lymphocytes; Thermogenesis |
| Ray, Joel G | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant-PA: INMD Start Up Funds (bridge funding) - Clinician Scientists | Abdominal visceral fat measured in early pregnancy and the risk of gestational diabetes mellitus | Gestational Diabetes Mellitus; Glucose Dysregulation; Insulin Resistance; Maternal Health; Metabolic Syndrome; Metabolism; Non-Alcoholic Fatty Liver Disease; Pre-Diabetes; Type 2 Diabetes Mellitus; Visceral Adiposity |
| Ray, Joel G | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | Abdominal visceral fat measured in early pregnancy as a novel and practical early predictor of gestational diabetes mellitus | Gestational Diabetes Mellitus; Glucose Dysregulation; Insulin Resistance; Maternal Health; Metabolic Syndrome; Metabolism; Pre-Diabetes; Type 2 Diabetes Mellitus; Visceral Adiposity |
| Rayner, Katey | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant - PA: ICRH - New investigators (Bridge Funding) | microRNA-33 Regulation of PGC-1alpha: Role in Atherosclerosis and Obesity | Atherosclerosis; Diabetes; Fatty Acid Metabolism; Inflammation; Microrna; Mitochondria; Obesity |
| Rayner, Katey | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | microRNA Regulation of PGC-1alpha: Role in Atherosclerosis and Obesity | Atherosclerosis; Diabetes; Fatty Acid Metabolism; Inflammation; Microrna; Mitochondria; Obesity |
| Reading, Stacey A | University of New Brunswick (Fredericton) | Partnerships for Health System Improvement (PHSI) | An Interprofessional Approach to Improving the Health of Obese Adults in New Brunswick | Chronic Disease; Exercise; Intervention Study; Obesity |
| Regnault, Timothy R | University of Western Ontario | Operating Grant | In utero insults and adult insulin resistance | Epigenetic Regulation Of Muscle Development; In Vivo Fetal Hypoxia And Muscle Development; Mitochondrial Biogenesis And Oxidative Phosphorylation; Mtor And Muscle Oxidative Function; Origins Of Adult Diseases; Ppars And Muscle Energy Balance |
| Regnault, Timothy R | University of Western Ontario | Project Grant | Modulating the in utero environment to prevent later life insulin resistance | Fetus; Hypoxia; Insulin Resistance; Iugr; Low Birth Weight; Metabolic Syndrome; Muscle Mitochondria; Oxidative Stress; Placental Insufficiency; Pyrroloquinoline Quinone |
| Reimer, Raylene A | University of Calgary | Operating Grant | Dietary manipulation of gut microbiota to manage obesity and insulin resistance | Gut Microbiota; Insulin Resistance; Maternal Health; Obesity; Pre-Conception; Prebiotic Fiber; Satiety Hormones; Sitagliptin |
| Reimer, Raylene A | University of Calgary | Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | Dietary manipulation of gut microbiota to manage obesity and insulin resistance | Gut Microbiota; Insulin Resistance; Maternal Health; Obesity; Pre-Conception; Prebiotic Fiber; Satiety Hormones; Sitagliptin |
| Rorsman, Patrik | University of Alberta | Operating Grant | Mechanisms by which long-term exposure to free fatty acids inhibit glucose-induced insulin secretion | Ca2+ Channels; Diabetes; Exocytosis; Free Fatty Acids; Insulin; Islets Of Langerhans |
| Reimer, Raylene A | University of Calgary | Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | Dietary manipulation of gut microbiota to manage obesity and insulin resistance | Gut Microbiota; Insulin Resistance; Maternal Health; Obesity; Pre-Conception; Prebiotic Fiber; Satiety Hormones; Sitagliptin |
| Retnakaran, Ravi R | Sinai Health System (Toronto) University of Toronto |
Operating Grant | Postpartum Progression to Type 2 Diabetes in Women with Recent Glucose Intolerance in Pregnancy: Pathophysiology, Biomarkers, and Clinical Implications | Beta-Cell Function; Gestational Diabetes Mellitus; Glucose Intolerance In Pregnancy; Type 2 Diabetes; Women's Health |
| Retnakaran, Ravi R | Sinai Health System (Toronto) University of Toronto |
Project Grant | Progression to Type 2 Diabetes in the 1st Decade after Glucose Intolerance in Pregnancy: Pathophysiology and Clinical Implications | Adiponectin; Gestational Diabetes; Glucose Tolerance; Pancreatic Beta-Cell Function; Postpartum; Type 2 Diabetes; Women's Health |
| Retnakaran, Ravi R | Sinai Health System (Toronto) University of Toronto |
Operating Grant | Exenatide and Insulin Glargine Combination Therapy for the Preservation of Pancreatic Beta-cell Function in Early Type 2 Diabetes: A Randomized Controlled Trial | Basal Insulin; Beta-Cell Function; Clinical Trial; Combination Therapy; Glp-1; Type 2 Diabetes |
| Retnakaran, Ravi R | Sinai Health System (Toronto) University of Toronto |
Operating Grant | A Pre-conception Cohort to Study Gestational Diabetes Mellitus: Pre-gravid Determinants, Early Pregnancy Bio-markers and Postpartum Cardio-metabolic Risk Factor Profile | Bio-Markers; Cardiovascular Risk; Clinical Research; Cohort Study; Gestational Diabetes; Pregnancy; Risk Factors; Women's Health |
| Retnakaran, Ravi R | Sinai Health System (Toronto) University of Toronto |
Operating Grant | A Randomized Controlled Trial to Evaluate Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes | Clinical Trial; Insulin Therapy; Pancreatic Beta-Cell Function; Type 2 Diabetes |
| Rhodes, Ryan E | University of Victoria (British Columbia) | Operating Grant | Evaluation of a Physical Activity Intervention for New Parents | Parenthood; Physical Activity |
| Richard, Caroline | University of Alberta | Project Grant | Establishing the importance of diet and insulin resistance in modulating immune function in obesity | Clinical Trial; Diet; Immune Function; Inflammation; Insulin Resistance; Obesity; T Cells; Type 2 Diabetes |
| Richard, Denis | Institut universitaire de cardiologie et de pneumologie de Québec - ULaval Université Laval |
Operating Grant | The role of DEPTOR in Energy Balance Regulation | Brain; Energy Homeostasis; Food Intake; Hypothalamus; Melanocortin System; Mtorc1; Neuropeptide Y; Proopiomelanocortin; Steroidogenic Factor 1; Thermogenesis |
| Richards, Brent | Lady Davis Institute for Medical Research (Mtl) McGill University/Université McGill |
Operating Grant | Mendelian randomization: Testing the causality of clinically-relevant biomarkers | Autoimmunity; Genetic Epidemiology; Gwas; Mendelian Randomization; Vitamin D |
| Rideout, Elizabeth J | University of British Columbia | Project Grant | Identifying genes and regulatory pathways that control sex differences in lipid storage using Drosophila as a model. | Adipose Tissue/Fat Body; Beta-Adrenergic/Adipokinetic Hormone Signaling Pathways; Drosophila Genetics; Ectopic Lipid Droplet Accumulation; Insulin Gene Transcription; Insulin Secretion; Insulin Signaling Pathway; Lipid Droplet Biology; Lipogenesis And Lipolysis; Physiology |
| Riediger, Natalie D | University of Manitoba | Project Grant | Sticky money: Exploring the acceptability of a sugar-sweetened beverage tax among Canadian Indigenous populations | Colonialism; Diabetes; Equity; First Nation; Indigenous; Obesity; Policy; Stigma; Sugar-Sweetened Beverage Tax; Youth |
| Riediger, Natalie D | University of Manitoba | Operating Grant: CCHS – Nutrition Analysis | A Call to Action towards food equity: Measuring obesity, diet quality, and food security disparities between Indigenous and non-Indigenous populations, 2004 vs. 2015 | Diet Quality; Food Security; Health Equity; Indigenous Health; Obesity; Socioeconomic Status |
| Rocheleau, Jonathan V | University Health Network (Toronto) University of Toronto |
Project Grant | Determining the impact of metabolic heterogeneity on the proliferation and survival of pancreatic beta-cells. | Beta-Cell; Genetically Encoded Sensors; Live Cell Imaging; Metabolism; Microfluidic Devices; Nadh; Nadph; Proliferation; Survival |
| Rocheleau, Jonathan V | University Health Network (Toronto)University of Toronto | Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | Endocrine FGFR1 signaling in the pancreatic beta-cell: association with Klotho-beta co-receptor and FGFRL1 decoy receptor. | Beta-Cell; Fgf21; Fgfr1; Fgfrl1; Klotho-Beta; Pancreatic Islet |
| Rodrigues, Brian B | University of British Columbia | Operating Grant | Endothelial heparanase regulation of cardiac metabolism | Cardiac Metabolism; Heparanase; Lipoprotein Lipase; Lipotoxicity; Vegf |
| Rodrigues, Brian B | University of British Columbia | Operating Grant | Regulation of endothelial heparanase following diabetes | Cardiac Metabolism; Endothelial Cells; Fatty Acid; Heparanase; Hyperglycemia; Lipoprotein Lipase |
| Rogers, Ian M | Sinai Health System (Toronto) University of Toronto |
Proof of Principle Program - Phase I | The Use of Multipotential Stem Cells for the Treatment of Peripheral Vascular Disease | Bone Marrow; Hematopoietic; Ischemias; Peripheral Vascular Disease; Stem Cells |
| Rose, David R | University of Waterloo (Ontario) | Operating Grant | Molecular Mechanism of Intestinal Glycosidases: Nutritional Starch Digestion and Regulation of Blood Glucose Levels | Carbohydrate Chemistry; Diabetes; Glycosidase Mechanism; Nutritional Starch Metabolism; Obesity; Protein Structure |
| Rose, Robert A | Dalhousie University (Nova Scotia) | Operating Grant | Impaired regulation of sinoatrial node function and atrial arrhythmogenesis in the diabetic heart | Atrial Fibrillation; Autonomic Nervous System; Diabetes Mellitus; Electrophysiology; Insulin Signaling; Ion Channels; Molecular Biology; Optical Mapping; Pi3k; Sinoatrial Node |
| Rosella, Laura C | Ontario Agency for Health Protection and Promotion (Toronto, Ontario) | Operating Grant | Maximizing population benefit and impact by applying population risk tools: A new direction for diabetes prevention in Canada | Decision-Making Tools; Diabetes; Epidemiology; Obesity; Population Risk Tools |
| Rosella, Laura C | Ontario Agency for Health Protection and Promotion (Toronto, Ontario)/L'Agence ontarienne de protection et de promotion de la santé University of Toronto |
Operating Grant-PA: INMD Start Up Funds (bridge funding) - Assistant Professors | Quantifying future risk and burden of type 2 diabetes in Canada: tools to inform the prevention of obesity and diabetes | Administrative Databases; Decision-Making Tools; Diabetes; Epidemiology; Multilevel Growth Models; Obesity; Population Risk Tools; Population Surveys; Survival Analysis |
| Rosella, Laura C | Ontario Agency for Health Protection and Promotion (Toronto, Ontario)/L'Agence ontarienne de protection et de promotion de la santé University of Toronto |
Operating Grant: Knowledge to Action | Supporting diabetes population health risk tools in practice: Partnerships to guide adaption, implementation and evaluation | Case Study; Diabetes; Integrated Knowledge Translation; Knowledge To Action; Knowledge Translation; Mixed Methods; Population Risk Tools; Risk Algorithms |
| Rosenberg, Lawrence | McGill University/Université McGill | Proof of Principle Program - Phase II | A Novel Regenerative Drug Therapy to Restore Natural Insulin Secretion in Diabetes Mellitus | Diabetes Melitus; Drug Discovery; Ingap Analogues; Ingap-Islet Neogenesis Associated Protein; Islet Neogenesis |
| Ross, Nancy A | McGill University/Université McGill | Operating Grant: CCHS – Nutrition Analysis | Does Neighbourhood Food Environment Amplify Canadian Social Inequalities in Diet, Health and Food Insecurity? | Dietary Recall; Food Insecurity; Retail Food Environments; Social Inequalities In Health; Type 2 Diabetes |
| Rost, Hannes L | University of Toronto | Project Grant | A novel approach for personalized metabolomics profiling using DIA mass spectrometry | Diabetes; Mass Spectrometry; Metabolomics; Method Development; Personalized Medicine; Systems Medicine |
| Rotondi, Michael A | York University (Toronto, Ontario) | Operating Grant | Aboriginal Health Counts: Advancing multivariable methods for respondent driven sampling | Aboriginal Health; Cardiovascular Disease; Chronic Conditions; Correlated Data Analysis; Diabetes; Hypertension; Multivariable Methods; Respondent-Driven Sampling |
| Rozakis-Adcock, Maria | University of Toronto | Operating Grant | Role of PHIP in the Hormonal Control of Liver Gluconeogenic Networks | Genetic Animal Models; Insulin/Glucagon; Liver; Pgc1/Torc2 Pathway; Transcriptional Regulation |
| Rudkowska, Iwona | Université Laval | Project Grant | Nutrigenomic approach to investigate the benefits of dairy product consumption on glucose homeostasis | Dairy Products; Gene-Diet Interactions; Glucose-Insulin Homeostasis; Metabolomics; Nutrigenomics; Personalized Nutrition; Transcriptomics; Type 2 Diabetes |
| Sairam, M. R | Institut de recherches cliniques de Montréal Université de Montréal |
Operating Grant | Discovery of Estrogen Mediated Fat Depot Specific Genes: Implications for Obesity and Metabolic Syndrome | Adipocytes; Adipokines; Aging; Gene Changes & Cloning; Inflammation; Sex Hormone Imbalances |
| Salbach, Nancy | University of Toronto | Project Grant | Getting Older adults OUTdoors (GO-OUT): A randomized controlled trial of a community-based outdoor walking program | Accelerometry/Gps; Community; Health-Related Quality Of Life; Knowledge Translation; Older Adult; Physical Activity; Qualitative; Randomized Controlled Trial; Walking Outdoors |
| Saleh, Maya | McGill University/Université McGill | Project Grant | Genetic and functional analyses of the inflammatory caspases and inflammasomes in obesity, metabolic inflammation and insulin resistance | Caspases; Inflammasome; Inflammation; Insulin Resistance; Metabolism; Obesity |
| Santerre, Paul | University of Toronto | Operating Grant | Monocyte directed tissue regeneration of a blood vessel substitute using a pro-cellular degradable tubular scaffold | Angiogenesis; Biomechanics; Endothelial Cells; In Vivo; Monocytes; Polymeric-Biomaterials; Stem Cells; Tissue Engineering; Vascular Grafts; Vascular Smooth Muscle Cells |
| Sapieha, Przemyslaw (Mike) S | CIUSSS Est-de-l'Ile-de- Montréal-Maisonneuve Rosemont Université de Montréal |
Operating Grant | Neuronal derived Semaphorin 3A contributes to vascular degeneration and misdirected pathological vessel growth in proliferative ischemic retinopathies | Angiogenesis; Endothelial Cell; Guidance Cues; Proliferative Retinopathies; Retinal Ganglion Cells; Semaphorin |
| Sarunic, Marinko V | Simon Fraser University (Burnaby, B.C.) | Project Grant | Sensorless Adaptive Optics Optical Coherence Tomography for Clinical Ophthalmology | Adaptive Optics; Age-Related Macular Degeneration (Amd); Cellular Resolution; Diabetic Retinopathy; Dry Amd; Imaging; Ophthalmology; Optical Coherence Tomography (Oct); Vision; Wavefront Sensorless Adaptive Optics |
| Sarunic, Marinko V | Simon Fraser University (Burnaby, B.C.) | Project Grant | Sensorless Adaptive Optics Optical Coherence Tomography for Clinical Ophthalmology | Adaptive Optics; Age-Related Macular Degeneration; Dry Amd; Glaucoma; Imaging; Ophthalmology; Optical Coherence Tomography; Vision; Wavefront Sensorless Adaptive Optics |
| Sauve, Yves | University of Alberta | Operating Grant | Retinopathy in a Cone-Rich Rodent Model of Spontaneous Type 2 Diabetes | Animal Model; Diabetic Retinopathy; Early Screening; Electrophysiology; Mechanisms Of Retina Degeneration And Dha Therapeutic Action; Nutrition; Vision Loss; Visual Function |
| Schertzer, Jonathan D | McMaster University | Foundation Grant | Microbiota and inflammatory triggers of metabolic disease | Diabetes; Immunometabolism; Microbiota; Obesity |
| Schertzer, Jonathan D | McMaster University | Operating Grant | NOD1 and NOD2 immunity regulate obesity-induced inflammation and insulin resistance | Adipocytes; Cell Biology; Diabetes; Glucose; Gut Bacteria; Immunity; Inflammation; Insulin Resistance; Metabolic Disease; Obesity |
| Schertzer, Jonathan D | McMaster University | Operating Grant-PA: INMD Start Up Funds (bridge funding) - New Investigators | NOD2 immunity protects against obesity-induced inflammation and insulin resistance | Cell Biology; Diabetes; Glucose; Gut Bacteria; Immunity; Inflammation; Insulin; Metabolic Disease; Obesity; Physiology |
| Schiffrin, Ernesto L | CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General/CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Hôpital juif McGill University/Université McGill |
Foundation Grant | Vascular remodeling in hypertension and cardiometabolic disease: from mice to humans | Angiotensin; Blood Vessels; Endothelin; Endothelium; Inflammation And Immunity; Intracellular Signaling And Oxidative Stress; Microrna And Messenger Rna; Molecular Biology; Pharmacology; Smooth Muscle Cells |
| Schmitz, Norbert | CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Douglas Hospital/CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Hôpital Douglas McGill University/Université McGill |
Operating Grant | Psychological problems associated with transition to insulin therapy in people with type 2 diabetes | Anxiety; Community Study; Coping; Depression; Diabetes; Epidemiology |
| Schmitz, Norbert | Douglas Mental Health University Institute (Montreal, QC)/Douglas Institut Universitaire en Santé Mentale | Operating Grant | Depression as a risk factor for type 2 diabetes: role of metabolic factors | Community Study; Depression; Diabetes; Metabolic Factors; Prospective Study |
| Schmitz, Norbert | CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Douglas Hospital/CIUSSS de l'Ouest-de-l'Ile-de-Montréal-Hôpital Douglas McGill University/Université McGill |
Operating Grant | Depression and disability in diabetes: a prospective community study | Community Sample; Depression; Diabetes; Disability; Longitudinal Relationship |
| Schricker, Thomas Peter S | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGillMcGill University/Université McGill | Operating Grant | Enhancing the anabolic effect of perioperative nutrition by insulin and maintenance of normoglycemia | Colorectal Cancer Surgery; Insulin Therapy; Muscle Physiology; Normoglycemia; Perioperative Nutrition; Protein Metabolism; Stable Isotope Tracer Studies |
| Schultz, Annette S | University of Manitoba | Project Grant | Indigenous People and Diabetes - Indigenous Knowledge and Wellness Practices disrupting Biomedical Colonization: Research Governed by Decolonizing and Two-Eyed Seeing Methods | Canada; Food And Type Two Diabetes; Food Sovereignty; Healthcare Services; Indigenous Health; Indigenous Knowledges |
| Schwartzman, Kevin | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Preventing tuberculosis in Inuit communitiies: Predicting what may work | Cost-Effectiveness Analysis; Decision Analysis; Inuit; Social Determinants; Transmission Model; Tuberculosis |
| Schwartzman, Kevin | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant - PA: First Nations, Inuit and Metis Health | Modeling the impact of interventions for tuberculosis control in Inuit communities | Cost-Effectiveness Analysis; Decision Analysis; Inuit; Social Determinants; Tuberculosis |
| Schwertani, Adel G | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Significance of the urotensin II system in the cardiovascular abnormalities of the metabolic syndrome | Cardiovascular Function; Drug Research; Gene Knockout; Hypertension; Immunoassay; Morphology; Obesity; Receptor Antagonists; Rt-Pcr; Western Blotting |
| Scott, Mark D | University of British Columbia | Operating Grant | Polymer-Grafted Allogeneic Leukocytes and Systemic Immune Modulation | Bioengineering; Lymphocyte; Polymer |
| Screaton, Robert A | Children's Hospital of Eastern Ontario Research Institute Inc/Institut recherche Centre hospitalier pour enfants de l'est de l'Ontario University of Ottawa/Université d'Ottawa |
Operating Grant | Role of MARK2:TORC2:CREB signaling in beta cell regeneration | Ampk Kinase Family; Beta Cell Regeneration; Beta Cells; Conditional Knockout; Creb; Torc2/Crtc2 |
| Screaton, Robert A | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Operating Grant | Novel Regulators of Mitochondrial Dynamics | Apoptosis; Cell Signaling; Knockout Mouse Models; Mitochondria; Mitochondrial Dynamics; Mitophagy; Neurons; Pancreatic Beta Cells; Parkin; Romo1 |
| Screaton, Robert A | Children's Hospital of Eastern Ontario Research Institute Inc | Operating Grant | The role of LKB1 in beta cell biology | Ampk; Beta Cells; Gene Expression Analysis; Glucose Metabolism; Insulin Secretion; Islets; Lkb1; Signal Transduction; Type 1 Diabetes; Type 2 Diabetes |
| Seguin, Cheryle A | University of Western Ontario | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Directed differentiation of pancreatic islet precursors from pluripotent human stem cells | Cell Differentiation; Diabetes; Human Embryonic Stem Cells; Islet Cell Replacement / Engineering; Lineage Specification; Transcription Factor |
| Shah, Baiju R | Institute for Clinical Evaluative Sciences-Toronto University of Toronto |
Operating Grant: Population Health Intervention Research | Evaluation of a strategy to improve cardiovascular disease screening and treatment for people with diabetes | N/A |
| Shah, Baiju R | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Operating Grant-PA: INMD Start Up Funds (bridge funding) - Clinician Scientists | Microalbuminuria and Retinopathy in Gestational Diabetes: The MARIGOLD Study | Gestational Diabetes; Metabolic Function; Microalbuminuria; Microvascular Complications; Pregnancy; Retinopathy |
| Shah, Baiju R | Institute for Clinical Evaluative Sciences-Toronto University of Toronto |
Project Grant | Derivation of risk prediction models and a computer microsimulation model in type 2 diabetes to aid clinical decision making and health technology assessment. | Complications; Cost Effectiveness; Long-Term Outcomes; Microsimulation Models; Patient-Centred Care; Risk Prediction; Type 2 Diabetes |
| Shah, Baiju R | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Operating Grant | Microalbuminuria and Retinopathy in Gestational Diabetes: The MARIGOLD Study | Gestational Diabetes; Metabolic Function; Microalbuminuria; Microvascular Complications; Pregnancy; Retinopathy |
| Shah, Baiju R | Institute for Clinical Evaluative Sciences-Toronto University of Toronto |
Project Grant | A pilot pragmatic randomized controlled trial to evaluate the impact of improving access to drugs on type 2 diabetes care, outcomes and costs | Acces To Medications; Diabetes Mellitus; Health Equity; Pilot And Feasibility Study; Randomized Controlled Trial |
| Sharma, Sangita | University of Alberta | Project Grant | Culturally Appropriate Practical Solutions Relevant to Indigenous Seniors and Caregivers Of Remote Northern Communities (CAPRICORN) | Caregivers; Elder Care; Health; Indigenous Health; Northern Canada; Seniors |
| Shen, Garry X | University of Manitoba | Project Grant | Promotion of breastfeeding for preventing type 2 diabetes and obesity in First Nations mothers and children in communities | Barrier Reduction; Breastfeeding; First Nations; Lifestyle Education; Nutrition; Pregnant And Postpartum Women; Rural And Remote Communities; Smartphone |
| Shen, Garry X | University of Manitoba | Project Grant | To determine the impact of breastfeeding, maternal food intake and infant gut microbiota on the risk of obesity and diabetes in First Nations women and children in rural communities | Breastfeeding; Children; Diabetes; First Nations Mothers; Gut Microbiome; Healthy Food Intake; Metabolomics Analysis; Obesity; Pregnancy; Rural And Remote Communities |
| Shen, Garry X | University of Manitoba | Operating Grant - Secondary Analysis of Databases | Impact of diabetes during pregnancy and breastfeeding on subsequent diabetes in First Nations mothers and children | Breastfeeding; Children And Adolescents; First Nations People; Gestational Diabetes; Pregnancy; Secondary Analysis Of Databases; Type 2 Diabetes |
| Sherifali, Diana T | McMaster University | Operating Grant | Evaluating the Effect of a Diabetes Health Coach in Individuals with Type 2 Diabetes. | Community; Diabetes Health Coach; Randomized Controlled Trial; Self-Management Education; Self-Management Support |
| Sievenpiper, John L | University of Toronto | Operating Grant: Sugar and Health | A randomized controlled trial of the effect of replacing sugar-sweetened beverage with non-nutritive sweetened beverage or water on gut microbiome and metabolic outcomes: Strategies To OPpose SUGARS with Non-nutritive sweeteners Or Water (STOP SUGARS NOW) trial | Gut Microbiome; Non-Nutritive Sweetened Beverages; Randomized Clinical Trial; Sugar-Sweetened Beverage |
| Simpson, Scot H | University of Alberta | Operating Grant | Is there a dose-response relationship between glyburide and cardiovascular outcomes? | Cardiovascular Disease; Diabetes; Dose-Response Relationship; Multivariate Cox Proportional Hazards; Population-Based Observational Study; Sulfonylureas (Glyburide); Time-Dependent Drug Exposure |
| Sinal, Christopher J | Dalhousie University (Nova Scotia) | Operating Grant | Differential Actions of the Novel Adipokine Chemerin Signaling Through Multiple Receptors | Adipocyte; Adipokine; Diabetes; Gene Regulation; Obesity; Pharmacology |
| Siu, Samuel C | University of Western Ontario | Operating Grant | Pregnancy and Subsequent Cardiovascular Risk in Women with Heart Disease | Atherosclerosis; Cardiovascular Risk Factors; Pregnancy |
| Sladek, Robert G | McGill University/Université McGill | Operating Grant | Functional characterization of susceptibility loci for Type 2 Diabetes Mellitus | Chromatin Structure; Diabetes Genetics; Diabetes Pathogenesis; Functional Genomics; Gene Expression; Transcription Factors |
| Sladek, Robert G | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Functional characterization and fine mapping of a type 2 diabetes risk locus near IRS1. | Chromatin Structure; Diabetes Genetics; Diabetes Pathogenesis; Functional Genomics; Gene Expression; Transcription Factors |
| Sladek, Robert G | Research Institute of the McGill University Health Centre/Institut de recherche du Centre universitaire de santé McGill McGill University/Université McGill |
Operating Grant | Integrated proteomics and genomics approach to characterize a risk locus for type 2 diabetes | Beta Cell Physiology; Common Genetic Variants; Diabetes Genetics; Diabetes Pathogenesis; Functional Genomics; Gene Expression; Protein Networks; Proteomics; Rare Genetic Variants; Transcription Factors |
| Smith, Peter M | Institute for Work & Health (Toronto) University of Toronto |
Operating Grant | Developing a gender/sex-sensitive understanding of how the psychosocial work environment is related to chronic disease | Gender; Psychosocial Work Environment; Stress |
| Smith, Peter M | Institute for Work & Health (Toronto) University of Toronto |
Operating Grant | A longitudinal examination of the relationship between immigrant labour market experiences, health behaviours and the incidence of diabetes and hypertension | Diabetes; Hypertension; Immigrants; Labour Market Experiences |
| Sokolowski, Marla B | University of Toronto | Operating Grant | Analyses of the multiple functions of the Drosophila foraging gene: a cGMP dependent protein kinase | Drosophila; Fat; Foraging Behaviour; Learning And Memory; Neurogenetics; Pleiotropy |
| Song, Weihong | University of British Columbia | Operating Grant | The role of RCAN1 in Alzheimer pathogenesis | Alzheimer's Disease; Amyloid Beta Protein; Diabetes; Drug Dedevelopment; High Glucose; Neuronal Apoptosis; Racn1; Transgeneic Mice |
| Sorisky, Alexander M | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Atherogenic adipocyte dysfunction induced by TSH | Adipocyte Biology; Cardiovascular Disease; Inflammation; Tsh Signaling |
| Stambolic, Vuk | Princess Margaret Cancer Centre (Toronto) University of Toronto |
Project Grant | Molecular mechanism of insulin receptor action in breast cancer with implications for therapy | Breast Cancer; Cell Biology And Biochemistry; Insulin Receptor; Molecular Mechanism; Mouse Transgenic And Knockout Models; Obesity; Receptor Crosstalk; Retrospective Analysis Of Clinical Trials; Signal Transduction; Xenograft |
| Stanford, William L | Ottawa Hospital Research Institute/Institut de recherche de l'Hôpital d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant | Characterizing the function of ZBTB8A in adipogenesis and its requirement for normal metabolism | Adipogenesis; Chip-Seq; Knockout Mice; Metabolic Dysfunction; Mouse Models Of Disease; Obesity; Rna-Seq; Systems Biology; Transcriptional Regulation |
| Steinberg, Gregory R | McMaster University | Operating Grant | Role of AMP-activated protein kinase in regulating inflammation in obesity: implications for the treatment of insulin resistance | Acetyl-Coa Carboxylase; Amp-Activated Protein Kinase; Fatty Acids; Inflammation; Innate Immunity; Insulin Resistance; Macrophage; Mouse Models; Obesity; Pgc1 And Mitochondria |
| Steinberg, Gregory R | McMaster University | Operating Grant | SOCS3 regulation of insulin and leptin sensitivity in obesity | Amp-Activated Protein Kinase; Insulin Resistance; Leptin Resistance; Metabolism; Obesity; Suppressor Of Cytokine Signaling |
| Steinberg, Gregory R | McMaster University | Project Grant | Inhibition of Peripheral Serotonin for Treating Obesity | Beige Adipose Tissue; Brown Adipose Tissue; Energy Expenditure; Inflammation; Insulin Resistance; Non-Alcoholic Fatty Liver Disease; Obesity; Type 2 Diabetes |
| Steinberg, Gregory R | McMaster University | Proof of Principle Program - Phase I | Development of a new therapy targeting adipose tissue metabolism for the treatment of obesity | Brown Adipose Tissue; Energy Expenditure; Obesity; Serotonin; Tryptophan Hydroxylase 1 |
| Steinberg, Gregory R | McMaster University | Operating Grant | Skeletal Muscle Energy Sensing and Insulin Sensitivity in Obesity | Amp-Activated Protein Kinase; Fatty Acid Oxidation; Insulin Resistance; Metformin; Mouse Models; Obesity; Protein Acetylation; Protein Phosphorylation; Salicylate; Type 2 Diabetes |
| Steinberg, Gregory R | McMaster University | Foundation Grant | Energy Sensing and Metabolism: From Mechanisms to New Therapies | Cardiovascular Disease; De Novo Lipogenesis; Endocrinology; Energy Expenditure; Insulin Resistance; Metabolism; Non-Alcoholic Fatty Liver Disease (Nafld); Non-Alcoholic Steahepatitis; Obesity; Type 2 Diabetes |
| Stone, Scot J | University of Saskatchewan | Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding | The role of DGAT2 in triacylglycerol synthesis and lipid droplet formation | Adipocyte; Lipid Biochemistry; Lipid Droplet; Obesity; Proteasome; Protein Interaction; Structure/Function; Subcellular Localization; Triacylglycerol; Ubiquitination |
| Stone, Scot J | University of Saskatchewan | Operating Grant - PA: Regional Partnership Program - Saskatchewan | The role of DGAT2 in triacylglycerol synthesis and lipid droplet formation | Adipocyte; Lipid Biochemistry; Lipid Droplet; Obesity; Proteasome; Protein Interaction; Structure/Function; Subcellular Localization; Triacylglycerol; Ubiquitination |
| Strachan, Shaelyn M | University of Manitoba | Project Grant | Examining the impact of a self-compassion intervention on physical activity behaviour among people with prediabetes: A pilot and feasibility study | Accelerometers; Exercise Psychology; Experimental Design; Feasibility Trial; Intervention; Mixed Methods; Physical Activity; Pilot Study; Self-Compassion; Self-Regulation |
| Strug, Lisa J | Hospital for Sick Children (Toronto) University of Toronto |
Operating Grant | Modification of Cystic Fibrosis Phenotypes in the Pancreas and Gut | Association; Cystic Fibrosis; Diabetes; Gene Modifiers; Heritability; Intestinal Obstruction; Modifiers; Pancreatic Function; Population-Based Study; Statistical Genetics |
| Strumpf, Erin C | McGill University/Université McGill | Operating Grant | Are Primary Care Teams effective? Evidence from Quebec's Family Medicine Groups on preventive care and from patients with multiple chronic conditions | Causal Inference With Observational Data; Co-Morbidity; Efficiency Of Health Care Services; Health Care Costs; Health Care Services Utilization; Population Health; Prevention; Primary Care; Primary Care Reform |
| Sung, Hoon Ki | Hospital for Sick Children (Toronto) University of Toronto |
Project Grant | Reversal of Adipose Fibrosis by Intermittent Fasting and VEGF | Adipocyte Precursor Cell; Adipose Fibrosis; Intermittent Fasting; Vascular Endothelial Growth Factor-A |
| Suuronen, Erik | University of Ottawa Heart Institute/Institut de cardiologie de l'Université d'Ottawa University of Ottawa/Université d'Ottawa |
Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Progenitor Cell Function in Defective Ischemia-induced Neovascularization in Diabetes | Advanced Glycation End Products; Diabetes; Endothelial Progenitor Cells; Ischemia; Neovascularization |
| Swardfager, Walter L | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Project Grant | Neurocognitive effects of osteocalcin in type 2 diabetes | Cognition; Diabetes; Exercise; Insulin Resistance; Metabolism; Osteocalcin |
| Sweeney, Gary | York University (Toronto, Ontario) | Operating Grant | Regulation of skeletal muscle metabolism by adiponectin | Adiponectin; Diabetes; Fatty Acid Uptake And Metabolism; Glucose Transport And Metabolism; Insulin; Obesity |
| Szaszi, Katalin | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant | TNF-alpha-induced Rho signaling and its role in intercellular junction regulation in kidney tubular cells | Cytoskeleton And Myosin; Epithelial Junctions; Fluorescent Microscopy; Transepithelial Permeability Measurements; Tubulointerstitial Inflammation; Tumor Necrosis Factor |
| Takano, Tomoko | McGill University/Université McGill | Operating Grant | Role of protein phosphatase 1B in glomerular podocyte function | Glomerular Podocytes; Nephrin; Protein Tyrosine Phosphatase; Proteinuria |
| Takano, Tomoko | McGill University/Université McGill | Operating Grant | Mechamisms of glomerular barrier dysfunction | Glomerular Podocytes; Proteinuria; Rho-Gtpases; Transgenic Mice |
| Tarasuk, Valerie S | University of Toronto | Operating Grant: Programmatic Grants to tackle health and health equity | Identifying policy interventions to reduce household food insecurity. | Burden Of Illness Methodology; Food Insecurity; International Comparison; Intervention Research; Policy Analysis; Secondary Data Analysis |
| Tarnopolsky, Mark A | McMaster University | Foundation Grant | Characterization of novel exersomes that mediate the systemic pro-metabolic effects of exercise in aging and neuromuscular disorders. | Aging; Endurance Exercise; Exosomes; Neuromuscular Disorders; Proteomics; Rna-Sequencing; Skeletal Muscle; Systemic Humoral Factors; Systemic Mitochondrial Metabolism; Type 2 Diabetes |
| Tarride, Jean-Eric | McMaster University | Operating Grant | Costs, health-related quality of life and cost-effectiveness of bariatric surgeries in Canada: an analysis of the Bariatric Registry | Bariatric Surgery; Bariatric Treatment; Co-Morbidities; Cost Burden; Morbid Obesity; Productivity Analysis; Return On Investment; Treatment Of Obesity |
| Taubert, Stefan | University of British Columbia | Operating Grant | Metabolic regulation by a network centered on a conserved Mediator subunit | Gene Expression/ Transcription; Genetics Of Regulatory Networks; Lipid Metabolism; Stress Response / Detoxification |
| Taubert, Stefan | University of British Columbia | Project Grant | Function of the Mediator complex in pancreatic islet cell maturation and maintenance | Beta Cells; Diabetes; Gene Regulation; Hesc; Maturation; Mediator Complex; Pancreas; Stress; Transcription; Transplantation |
| Taylor, Jennifer P | University of Prince Edward Island (Charlottetown) | Operating Grant: Pathways Implementation Research Team – Component 1 | Food is Medicine: Addressing Obesity and Diabetes by Building Food Security and Food Sovereignty Among Prince Edward Island First Nations | Best Practices Review; Community Consultation; Diabetes; First Nations; Food Security; Food Sovereignty; Obesity |
| Tchernof, André | Université Laval | Operating Grant | Adipose tissue prostaglandins as mediators of disease in women with male-pattern obesity | Adipose Tissue; Cell Biology; Obesity; Prostaglandins; Visceral Obesity; Women |
| Tchernof, André | Université Laval | Operating Grant | Androgen inactivation and aldo-keto reductases 1C in adipose cells | Adipocyte; Aldo-Keto Reductase; Androgens; Androstanediol; Dihydrotestosterone; Obesity |
| Tchernof, André | Centre hospitalier de l'Université Laval (Québec) Université Laval |
Operating Grant | Modulation of the androgenic message in adipose tissue | 5alpha-Reductases; Adipocyte; Androgens; Dihydrotestosterone; Obesity; Testosterone |
| Thompson, Jennifer A | University of Calgary | Project Grant | Metabolic disorders of pregnancy and early-onset disease risk in the offspring: role of adipose tissue expandability | Fetal Development; Fetal Programming; Gestational Diabetes; Maternal Obesity; Metabolic Disease |
| Tieleman, Peter D | University of Calgary | Operating Grant - PA: Institute of Genetics (Bridge Funding) | Computer simulations of ABC transporters | Abc Transporters; Cancer; Cystic Fibrosis; Molecular Dynamics Simulation; Molecular Modeling; Multidrug Resistance |
| Timmons, Brian W | McMaster University | Operating Grant | Metabolic flexibility in obese youth: Exercise as a screening test and a treatment | Childhood Obesity; Clinical Care; Exercise; Glucose Metabolism |
| Tonelli, Marcello | University of Alberta | Operating Grant - PA: Institute of Health Services and Policy Research | Risk of adverse effects among elderly statin users | Adverse Effect; Diabetes; Elderly; Epidemiological Study; Hypertension; Kidney Disease; Statin |
| Tonelli, Marcello | University of Calgary | Operating Grant | Cardiovascular risk among cancer survivors | Cancer; Chemotherapy; Epidemiological Study; Heart Disease; Stroke |
| Topisirovic, Ivan | Lady Davis Institute for Medical Research (Mtl) McGill University/Université McGill |
Operating Grant | Identification and characterization of novel substrates of the mammalian target of rapamaycin complex 1 (mTORC1). | Cell Proliferation And Growth; Mammalian Target Of Rapamycin; Mass Spectrometry; Metabolism; Tumorigenesis |
| Toth, Cory C | Hotchkiss Brain Institute (University of Calgary) University of Calgary |
Operating Grant | The Diabetic Brain resulting from Insulin Deficiency and loss of PI3K/Akt signaling | Cerebral Atrophy; Cognitive Decline; Diabetes; Insulin; White Matter Abnormalities |
| Toth, Ellen L | University of Alberta | Operating Grant - PA: First Nations, Inuit and Metis Health | Diabetes in pregnancy in Aboriginal women: a mixed-methods study in three provinces | Aboriginal; Community; Determinants Of Health; Diabetes In Pregnancy; Epidemiology; Ethnicity; Pregnancy; Qualitative |
| Tousignant, Pierre | Direction régionale de santé publique (CIUSSS - CSIM) | Partnerships for Health System Improvement (PHSI) | Mise en oeuvre d'un réseau intégré de prévention et de gestion du risque cardiométabolique en 1re ligne à Montréal | Chronic care model; Collaboration interorganisationnelle; Diabète; Hypertension artérielle; Interdisciplinarité; Maladies cardiométaboliques; Maladies chroniques; Réseau intégré de services; Services de première ligne; services de santé |
| Tremblay, André | Centre hospitalier universitaire Sainte-Justine Université de Montréal |
Operating Grant | Role of Ghrelin Signaling on Peripheral Nuclear Receptors and the Regulation of Lipid and Energy Metabolism | Adipocytes; Fatty Acid Metabolism; Ghrelin; Obesity; Ppar Nuclear Receptors; Thiazolidinediones |
| Tremblay, André | Université de Montréal | Project Grant | Peripheral regulation of PPAR Nuclear Receptors in energy metabolism | Cd36 Scavenger Receptor; Lipid Metabolism; Metabolic Disorders; Mitochondria; Ppar Nuclear Receptors |
| Seda, Ondrej | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant: Industry-partnered Collaborative Research - Other Partner | Telomere attrition rate as predictor of cardiovascular complications of type 2 diabetes | Cardiovascular Disease; Diabetes Mellitus; Longitudinal Study; Telomere Length |
| Tremblay, Michel L | McGill University/Université McGill | Operating Grant | PTP1b as a target in human cancer | Cancer Therapies; Oncogene; Receptor Trafficking; Tissue Micro Array; Transgenic Animal Models; Tyrosine Phosphatase |
| Tsuji, Leonard J | University of Waterloo (Ontario) | Operating Grant - Aboriginal Health Intervention - full application | Fostering Adaptive Capacity and Resilience to Climate Change in Sub-Arctic First Nations: Addressing Food Security and Health Issues through Agroforestry Stewardship Practices | Adaptation; Agroforestry; Climate Change; First Nations; Food Security; Home Gardens; Nutrition; Obesity; Sub-Arctic; Sustainability |
| Tu, Karen | Institute for Clinical Evaluative Sciences-Toronto University of Toronto |
Operating Grant | Feedback GAP: a trial of Goal-setting and Action-Plans to increase the effectiveness of audit and feedback interventions in primary care. | Audit and Feedback; Cardiovascular Risk; Cluster Randomized Trial; Diabetes; Electronic Medical Records; Ischemic Heart Disease; Knowledge Translation; Mixed Methods; Primary Care; Quality Of Care |
| Tupling, Allan R | University of Waterloo (Ontario) | Operating Grant | The Role of Sarcolipin in Thermogenesis, Diet-induced Obesity and Glucose Intolerance | Ca2+ Pump; Indirect Calorimetry; Insulin Secretion; Metabolic Rate; Muscle Glucose Uptake; Sarcolipin; Skeletal Muscle; Transgenic Mouse |
| Ungrin, Mark D | University of Calgary | Operating Grant | Optimizing the size and composition of beta cell aggregates to improve islet graft survival | Cell Survival; Controlled Cellular Aggregation; Extracellular Matrix; Islet Transplantation; Metabolic Transport Processes; Mixed Cellular Aggregates; Oxygenation; Retention Of Function; Size Control; Surface:Volume Ratio |
| Unniappan, Suraj | University of Saskatchewan | Operating Grant | Neuroendocrine Regulation of Energy Homeostasis | Diabetes; Energy Balance; Glucose Homeostasis; Metabolism; Obesity; Pancreas |
| Unniappan, Suraj | University of Saskatchewan | Operating Grant | Nesfatin-1 Regulation of Glucose and Energy Homesotasis | Beta Cells; Blood Glucose; Body Weight; Food Intake; Gastrointestinal Tract; Gluconeogenesis; Insulin; Liver; Metabolism; Pancreatic Islets |
| Urowitz, Murray B | University Health Network (Toronto) University of Toronto |
Operating Grant | The Metabolic Syndrome in Patients with Systemic Lupus Erythematosus (SLE): Clinical, Therapeutic and Genetic Determinants in an International Inception Cohort Registry | Atherosclerotic Risk; Biomarkers; Genetics; Longitudinal Cohort; Metabolic Syndrome; Systemic Lupus |
| Ussher, John Edward R | University of Alberta | Project Grant | The GLP-1 Receptor & Myocardial Glucose Oxidation | Glucagon-Like Peptide-1; Glucagon-Like Peptide-1 Receptor; Glucose Oxidation; Liraglutide; Type 2 Diabetes |
| van der Kooy, Derek J | University of Toronto | Foundation Grant | Cell lineage and neural development | Asymmetric Cell Division; Brain Development; Cell Reprogramming; Neural Stem Cells; Neurobiology Of Motivation; Pancreatic Stem Cells; Retinal Stem Cells |
| Vanasse, Alain | Université de Sherbrooke | Operating Grant: Prevention of Cardiovascular and Respiratory Diseases | Inégalités sociales et géographiques dans la prévention primaire des maladies cardiovasculaires et cérébrovasculaires | Facteurs de risque; Géomatique de la santé; Inégalités; Maladies cardiovasculaires; Santé des populations; Système d'information Spatio-Temporel |
| Vance, Dennis E | University of Alberta | Operating Grant | Phosphatidylcholine and Metabolic Disorders | Adeno-Associated Virus; Diabetes; Obesity; Phosphatidylcholine; Phospholipid Methylation; Vagotomy |
| Vasconcelos, Sara N | University Health Network (Toronto) University of Toronto |
Operating Grant - PA: ICRH - New investigators (Bridge Funding) | Arterial-venous specification during adult neovascularization | Angiogenesis; Arterial-Venous Specification; Intravital Epifluorescence Videomicroscope; Neovascularization; Perivascular Cells; Regenerative Medicine; Skin Fold Window Chamber; Transgenic Mice; Vascular Biology; Vessel Remodeling |
| Vaucher, Elvire | Université de Montréal | Operating Grant | Vascular inflammation in the diabetic retina: involvement of kinin B1 Receptor | Diabetic Retinopathy; Endothelial Dysfunction; Kinin; Microangiopathy; Microcirculation; Ocular Blood Flow; Retina; Type 1 Diabetes; Type 2 Diabetes; Vascular Inflammation |
| Veilleux, Alain | Inst. on Nutraceuticals & Functional Foods (QC) | Operating Grant | Role of intestinal microenvironment and insulin resistance in postprandial dyslipidemia in humans | Cardiovascular Disease; Cellular Biology; Classical Lipidology And Lipidomics; Insulin Resistance; Lipid Tracer Assay; Obesity And Diabetes; Protein; Rna; Small Intestine |
| Venkateswaran, Vasundara | Sunnybrook Research Institute (Toronto, Ontario)University of Toronto | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Utilizing metformin to enhance the efficacy of androgen deprivation therapy in prostate cancer | Bicalutamide; Insulin/Igf Signaling; Ionizing Radiation; Metformin; Obesity; Prostate Cancer Treatment |
| Venkateswaran, Vasundara | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Operating Grant | Metformin: A radio- and chemo- sensitizer in prostate cancer | Castrate Resistant Prostate Cancer; Docetaxel; Hyperinsulinemia; Insulin/Igf Signaling; Ionizing Radiation; Metformin; Obesity; Prostate Cancer; Prostate Cancer Stem Cells; Xenograft |
| Verchere, Bruce C | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | Amyloid-induced islet inflammation and beta cell dysfunction | Amylin; Beta Cell; Diabetes; Iapp; Inflammasome; Innate Immunity; Islet; Islet Amyloid; Islet Inflammation; Toll-Like Receptors |
| Ehses, Jan A | University of British Columbia | Operating Grant | Regulatory macrophages in islet inflammation and type 2 diabetes | Diabetes; Inflammation; Insulin; Islets Of Langerhans; Macrophages; Pancreatic Beta Cell |
| Verchere, Bruce C | BC Children's Hospital Research InstituteUniversity of British Columbia | Project Grant | Islet macrophages: regulators of beta cell function in health and diabetes | Amyloid; Beta Cell; Diabetes; Iapp; Inflammasome; Insulin; Islet; Macrophage |
| Verchere, Bruce C | BC Children's Hospital Research Institute University of British Columbia |
Operating Grant | Processing of proIAPP: Role in islet amyloid formation | Amylin; Amyloid; Beta Cell; Cell Biology; Histology; Iapp |
| Verchere, Bruce C | University of British Columbia | Project Grant | Genetic and acquired defects in islet prohormone processing in diabetes | Beta Cell; Biomarkers; Diabetes; Insulin; Islet Amyloid Polypeptide; Islet Biology; Post-Translational Modification; Prohormone; Prohormone Processing; Proinsulin |
| Verchere, Bruce C | BC Children's Hospital Research Institute University of British Columbia |
Project Grant | Islet macrophages: regulators of beta cell function in health and diabetes | Amyloid; Beta Cell; Diabetes; Iapp; Inflammasome; Inflammation; Innate Immunity; Insulin; Islet; Macrophage |
| Verma, Subodh S | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant: SPOR Innovative Clinical Trial Multi-Year Grant | Reducing Diabetic Foot Complications through a Multidisciplinary Chiropodist Based Intervention | Chiropodist-Led Care; Diabetes; Foot Ulcer; Peripheral Arterial Disease; Pragmatic Trial Design |
| Vine, Donna | University of Alberta | Operating Grant | Dietary Fish Oil: A Treatment for Hyperlipidemia in Young Women with Polycystic Ovary Syndrome | Apob Triglyceride-Rich Lipoprotein Kinetics; Apob-Lipoprotein Remnants; Cardiometabolic Risk Factors; Cardiovascular Disease Risk; Dietary Intervention; Fasting And Non-Fasting Postprandial Lipid Metabolism; Metformin; N-3 Polyunsaturated Fatty Acid (Fish Oil); Polycystic Ovary Syndrome; Randomized Parallel Intervention |
| Vohl, Marie-Claude | Université Laval | Operating Grant | A study of genetic and epigenetic factors influencing obesity-related metabolic complications. | Association Studies; Changes; Genetic; Metabolic Complications; Obesity; Transcriptional |
| Walker, Jennifer | University of Toronto | Operating Grant | Unlocking Health Information for Older First Nations Populations | Administrative Data; Chronic Disease; First Nations; Frailty; Indigenous Health; Multimorbidity |
| Wang, Rennian | University of Western Ontario | Project Grant | Studies of the functional role of pancreatic stellate cells (PaSCs) during islet differentiation, regeneration and diabetes. | Diabetic Mouse Models; Human Fetal Pancreas; Islet Cell Differentiation; Islet Regeneration; Islet-Epithelial Cell Cluster Coculture; Pancreatic Duct Ligation; Pancreatic Stellate Cells; Pancreatic Stellate Cells Inhibitor |
| Wang, Rennian | University of Western Ontario | Operating Grant | Analysis of c-Kit and insulin receptor signaling interactions in regulating pancreatic beta-cell function and islet vasculature | Beta-Cell Specific C-Kit Transgenic Mice; C-Kit Wv Mutation Mice; Cross-Talk Between C-Kit And Insulin Receptors; High-Fat Diet Diabetes; Insulin Receptor/Insulin Receptor Substrates; Islet Biology; Islet Vasculature; Pi3k/Akt/Gsk3b Signaling Pathway; Stem Cell Factor/C-Kit Recptor; Vegf Expression |
| Wassmann, Sven | Lady Davis Institute for Medical Research (Mtl) McGill University/Université McGill |
Operating Grant | Role of AT1 receptor activation in progenitor cell biology, endothelial regeneration, atherosclerosis, insulin resistance, and adipogenesis | Atherosclerosis; Endothelial Progenitor Cells; Endothelial Regeneration / Function; Immunohistochemistry/Facs/Cell Culture; Insulin Sensitivity; Knockout Mice / Bone Marrow Transplantations |
| Welsh, Donald G | University of Calgary | Operating Grant | Electrical and Second Messenger Communication in Resistance Arteries | Gap Junctions; Ion Channels; Smooth Muscle Physiology; Vascular Communication |
| Werstuck, Geoffrey H | McMaster University | Operating Grant | The Role of the Hexosamine Biosynthesis Pathway in Diabetes-Induced Accelerated Atherosclerosis | Atherosclerosis; Diabetes Mellitus; Endoplasmic Reticulum Stress; Glutamine:Fructose-6 Phosphate Amidotransferase; Mouse Models |
| Werstuck, Geoffrey H | McMaster University | Operating Grant | The Role of the Hexosamine Biosynthesis Pathway in Diabetes-Induced Accelerated Atherosclerosis | Atherosclerosis; Diabetes Mellitus; Endoplasmic Reticulum Stress; Glutamine:Fructose-6 Phosphate Amidotransferase; Mouse Models |
| Werstuck, Geoffrey H | McMaster University | Operating Grant | Mechanisms by which Diabetes Mellitus promotes the development and progression of atherosclerosis | Atherosclerosis; Diabetes Mellitus; Endoplasmic Reticulum Stress; Glutamine:Fructose-6 Phosphate Amidotransferase; Mouse Models |
| Wheeler, Michael B | University of Toronto | Operating Grant | Beta cell-stimulus secretion coupling: The role of zinc transport and its link to type 2 diabetes. | Beta Cell; Glucagon Secretion; Insulin Secretion; Type 2 Diabetes; Zinc Transporter Mutations And Diabetes Risk; Znt8 Transporter Function |
| Wheeler, Michael B | University of Toronto | Operating Grant | Islet cell stimulus-secretion coupling: The role of mitochondrial uncouplers | Beta Cell Metabolism; Beta Cell Uncoupling Proteins; Insulin Secretion; Islet Cell Death; Obesity; Type 2 Diabetes |
| Wheeler, Michael B | University of Toronto | Operating Grant | Mechanisms linking beta cell dysfunction to type 2 diabetes | Biomarkers; Diabetes; Gestational Diabetes; Insulin Secretion; Metabolomics; Pancreatic Beta Cell |
| Whitlock, Richard | McMaster University | Operating Grant - PA: Musculoskeletal Health, Arthritis, Skin and Oral Health | Transcutaneous oximetry, transcutaneous carbon dioxide and supplemental oxygen therapy in lower limb amputations - An observational study | Diabetes; Lower Limb Amputations; Observational Cohort Study; Orthopaedic Surgery; Supplemental Oxygen Therapy; Transcutaneous Carbon Dioxide; Transcutaneous Oximetry; Vascular Complications; Vascular Surgery; Wound Healing |
| Willing, Benjamin P | University of Alberta | Operating Grant - PA: Reproductive and Child Heath (start-up grants) | Programming effects of neonatal antibiotics on metabolic outcomes | Antibiotics; Beta Cell; Diabetes; Epigenetics; Immunity; Infant; Metabolic Disease; Microbiota; Obesity |
| Winer, Daniel A | University Health Network (Toronto) University of Toronto |
Operating Grant | Mechanisms of B cell Pathogenicity in Insulin Resistance | Adaptive Immune System; Antibodies; Antigen Specificity; B Cells; Innate Immune System; Insulin; Insulin Resistance; Metabolic Syndrome; Obesity; Type 2 Diabetes |
| Winer, Daniel A | University Health Network (Toronto) University of Toronto |
Foundation Grant | The role of the immune system in obesity related insulin resistance and metabolic disease | Adaptive Immune System; B Cells; Fatty Liver Disease; Immunometabolism; Innate Immune System; Insulin Resistance; Metabolic Syndrome; Obesity; T Cells; Type 2 Diabetes |
| Winer, Daniel A | University Health Network (Toronto) University of Toronto |
Operating Grant | Defining Adaptive Immune Mechanisms of Insulin Resistance | Adaptive Immune System; Antibodies; Apoptosis; B Cells; Innate Immune System; Insulin Resistance; Metabolic Syndrome; Obesity; Type 2 Diabetes |
| Wishart, David S | University of Alberta | Foundation Grant | New Resources for Chemical Genomics and Metabolomics in Biomedicine | Bioinformatics; Chemical Genomics; Chemical Libraries; Databases; Disease Biomarkers; Metabolomics; Pathways; Software Development |
| Wolever, Thomas M | University of Toronto | Operating Grant | Role of colonic short chain fatty acids in obesity and insulin resistance | Colonic Fermentation; Gut Hormones; Humans; Insulin Sensitivity; Obesity; Whole Body Metabolism |
| Wolever, Thomas M | University of Toronto | Operating Grant | The effect of a low glycemic index (GI) diet on maternal glycemic control and maternal and neonatal markers of postpartum diabetes risk in women with gestational hyperglycemia | Clinical Trial; Dietary Carbohydrates; Gestational Diabetes; Glycemic Control; Glycemic Index; Humans |
| Woo, Minna N | University Health Network (Toronto) University of Toronto |
Operating Grant | Dissecting inflammatory and apoptotic signaling in adipocytes | Apoptosis; Caspase; Cre-Lox P; Diabetes; High Fat Diet; Inflammasome; Inflammation; Insulin Resistance; Knockout Mice; Obesity |
| Woo, Minna N | University Health Network (Toronto) University of Toronto |
Operating Grant | Hypothalamic regulation of adipocytes and peripheral insulin sensitivity | Adipocyte; Cre-Loxp; High Fat Diet; Insulin Resistance; Knockout Mice; Obesity |
| Woo, Minna N | University Health Network (Toronto) University of Toronto |
Operating Grant | Genetic Determinants of Pancreatic Beta Cell Homeostasis | Cre Lox P; Diabetes; Epo Signaling; Erythropoietin; Knockout Mice; Pancreatic Beta Cells |
| Woodgett, James (Jim) R | Lunenfeld-Tanenbaum Research Institute (Toronto) University of Toronto |
Foundation Grant | Genetic analysis of signal transduction pathways involved in human diseases | Cell Regulation; Diabetes; Metabolism; Oncogene; Protein Kinase; Signal Transduction; Stem Cell; Transgenic Mouse |
| Woolcott, Christy G | IWK Health Centre (Halifax) Dalhousie University (Nova Scotia) |
Operating Grant - PA: Regional Partnership Program - Nova Scotia | Pregnancy characteristics and maternal long term weight-related outcomes: a cohort study | Adipokines; Biological Mediators; Cardiovascular Disease; Chronic Disease Risk; Diabetes; Epidemiology; Life Course Health; Obesity; Pregnancy; Women's Health |
| Woolcott, Christy G | IWK Health Centre (Halifax) Dalhousie University (Nova Scotia) |
Operating Grant | Do pregnancy characteristics help to predict the future risk of maternal cardiovascular outcomes? A population-based longitudinal cohort study | Cardiovascular Disease; Cohort; Diabetes; Epidemiology; Hypertension; Pregnancy; Risk Prediction; Women'S Health |
| Wright, David | University of Guelph | Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding) | Regulation of Adipose Tissue Metabolism | Adipose; Exercise; Fasting; Gene Expression; Knockout Mice; Mitochondria; Rat; Re-Esterification; Signaling; Tissue Culture |
| Wright, David | University of Guelph | Operating Grant | Novel Effects of Exercise on Adipose Tissue Insulin Action | Adipose; Exercise; Glycogen; Insulin; Knockout Mice; Lipolysis; Liver; Obesity; Signaling; Skeletal Muscle |
| Wu, Lingyun (Lily) | University of Saskatchewan | CIHR/Regional Partnership Program/Operating Grants | Mechanisms and intervention for methyglyoxal-induced glycation of AKT1 | Akt1; Methylglyoxal And Ages; Proliferation; Smg08; Smooth Muscle Cells; Vascular Remodeling |
| Yang, Kaiping | University of Western Ontario | Operating Grant | Early-life origins of visceral adiposity | Adipose Tissue Growth And Development; Cellular And Molecular Mechanisms; Early-Life Progamming; Knockout Mouse Models; Maternal Protein Restriction; Visceral Adiposity |
| Yao, Zemin | University of Ottawa/Université d'Ottawa | Operating Grant | New lipid and protein factors regulating hepatic TAG homeostasis | Apociii; Er Stress; Hepatosteatosis; Lumenal Lipid Droplets; Proteomics; Systems Biology; Triacylglycerol; Vldl Overproduction |
| Yu, Catherine | St. Michael's Hospital (Toronto) University of Toronto |
Operating Grant: Knowledge to Action | Development, testing and feasibility of an interprofessional shared decision-making and goal-setting decision aid for patients with diabetes in clinical care | Decision Aid; Diabetes Mellitus; Guideline Adherence; Interprofessional Care; Knowledge Translation; Multimorbidity; Shared Decision-Making |
| Yu, Catherine | University of Toronto | Operating Grant: Knowledge to Action | Effect of a web-based self-management intervention for patients with type 2 diabetes on clinical and psychological outcomes | Integrated Knowledge Translation; Patient Self-Management; Qualitative Methodology; Type 2 Diabetes; Web-Based Technology |
| Yue, Jessica T | University of Alberta | Project Grant | Lipid homeostasis regulation by brain glucagon signalling | Central Nervous System; Diabetes; Dorsal Vagal Complex; Glucagon; Lipid Metabolism; Liver; Mediobasal Hypothalamus; Obesity |
| Yuen, Darren A | St. Michael's Hospital (Toronto) University of Toronto |
Project Grant | Sweet and Stiff: How diabetes activates YAP and TAZ to trigger kidney fibrosis | Diabetes; Diabetic Nephropathy; Fibrosis; Rhoa; Taz; Yap |
| Yusuf, Salim | McMaster University | Foundation Grant | Prospective Urban Rural Epidemiology (PURE) Program: causes, consequences, and impact of health systems for CVD and other NCDs | Cardiovascular Diseases; Environment And Health; Epidemiology; Global Health; Health Systems; Non-Communicable Diseases; Population Health; Risk Factors |
| Yusuf, Salim | McMaster University | Operating Grant | INTERSTROKE: Importance of Conventional and Emerging Risk Factors for Stroke in Different Regions and Ethnic Groups of the World | Prevention; Risk Factors; Stroke |
| Zamponi, Gerald W | University of Calgary | Foundation Grant | Voltage gated calcium channels: molecular targets for pain therapeutics | Calcium Channels; Diabetic Neuropathy; G Protein Coupled Receptors; Inflammatory Pain; Neuropathic Pain; Pain; Ubiquitination |
| Zeng, Haishan | B.C. Cancer Research Centre (Vancouver) University of British Columbia |
Project Grant | Multiphoton Photothermolysis Based Laser Therapy for Precision Treatment of Neovascular Eye Diseases | Biophotonics; Confocal Microscopy; Corneal Neovascularization; Diabetic Retinopathy; Eye Diseases; Laser Therapy; Macular Degeration; Multiphoton Microscopy; Multiphoton Photothermolysis; Ophthalmology |
| Zhai, Guangju | Memorial University of Newfoundland | Operating Grant - PA: IMHA - New Invest.– Musculoskeletal Health Bridge Funding | The link between osteoarthritis and diabetes mellitus | Advanced-Glycation End-Products; Diabetes Mellitus; Glucose Transporter 1; Metabolic Markers; Methylglyoxal; Osteoarthritis |
| Zhang, Shao-Ling | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Maternal Diabetes, Reactive Oxygen Species, Nephrogenesis and Perinatal Programming | Hypertension; Intrarenal Angiotensin Converting Enzyme-2; Kidney Injury; Maternal Diabetes; Perinatal Programming; Reactive Oxygen Species (Ros); Renin-Angiotensin System |
| Zhang, Shao-Ling | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Project Grant | Maternal Diabetes Induces Perinatal Programming of Hypertension and Chronic Kidney Disease: Role Of Hedgehog Interacting Protein (Hhip) | Chronic Kidney Disease; Hedgehog Interacting Protein; Hypertension; Maternal Diabetes; Perinatal Programming; Transgenic And Knockout Mouse Models |
| Zhang, Shao-Ling | Centre hospitalier de l'Université de Montréal (CHUM) Université de Montréal |
Operating Grant | Maternal Diabetes and Perinatal Programming: Role of Reactive Oxygen Species | Hypertension; Intrarenal Angiotensin Converting Enzyme-2; Kidney Injury; Maternal Diabetes; Perinatal Programming; Reactive Oxygen Species (Ros); Renin-Angiotensin System |
| Zochodne, Douglas W | University of Calgary | Operating Grant | Rescue of diabetic sensory neurodegeneration through insulin signaling | Diabetic Polyneuropathy; Experimental Diabetes; Insulin; Neurodegeneration; Sensory Neurons |
| Zuniga-Pflucker, Juan C | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Operating Grant | Characterization and lineage commitment of progenitor thymocytes | Delta-Like; Eva1; Immune Reconstitution; Lymphocyte Development; Lymphocyte Progenitors; Notch Signaling; Stromal Cells; T Cell Development; Thymus; Thymus Epithelial Cells |
| Zuniga-Pflucker, Juan C | Sunnybrook Research Institute (Toronto, Ontario) University of Toronto |
Operating Grant - Priority Announcement: Infection and Immunity (Bridge Funding) | Characterization and lineage commitment of progenitor thymocytes | Delta-Like; Eva1; Immune Reconstitution; Lymphocyte Development; Lymphocyte Progenitors; Notch Signaling; Stromal Cells; T Cell Development; Thymus; Thymus Epithelial Cells |
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