Results – Operating Grant: Mechanisms in Brain Aging and Dementia (Factors and Mechanisms that Impact Cognitive Health in Aging)

The Canadian Institutes of Health Research (CIHR) Institute of Aging is pleased to share the funding decision for the Brain Health and Cognitive Impairment in Aging (BHCIA) Research Initiative: Mechanism in Brain Aging and Dementia Operating Grants.

This Funding Opportunity (FO) was launched to advance the understanding about risk reduction and protective factors involved in promoting cognitive health and mitigating the changes that occur in the onset and progression of cognitive impairment and dementia in aging, while considering the intersection of different factors, including the social determinants of health and other structural and systemic barriers.

With the support of our partners, the CIHR Institute of Infection and Immunity, CIHR Institute of Genetics, and the Azrieli Foundation (including the Canadian Centre for Caregiving Excellence), 13 projects were funded with a total investment of 8.7 million dollars.

Lora Appel, York University, Ontario

VR&R: Providing Respite to Caregivers by Managing Behavioural and Psychological Symptoms in People with Dementia Using Immersive VR-Therapy

Dawn Bowdish, McMaster University, Ontario

Uncovering the role of chronic inflammation and serious respiratory infections in brain aging and cognitive impairment

Brandy Callahan, University of Calgary, Alberta

Aging with neurodiversity: Investigating allostatic and vascular health as modifiable factors impacting brain aging in older adults with ADHD

Jean Chen, Baycrest Centre for Geriatric Care, Ontario

Neurological markers of mid-life depression and cognitive behavioural therapy (CBT) in dementia caregivers: the role of neuroinflammation

Mahsa Dadar, McGill University, Quebec

Incorporating Diversity in Alzheimer's Disease Research: Developing Representative and Generalizable models

Brianne Kent, Simon Fraser University, British Columbia

Multiscale dynamical system modelling to understand resilience in brain aging and dementia

Andrew Lim, Sunnybrook Research Institute, Ontario

Healthy Sleep to Promote Resistance and Resilience to Alzheimer's Disease Related Brain Changes: An Integrated Wearable EEG, Genomic, MR Imaging, and Plasma Biomarker Study of Over 2600 Participants in the Canadian Longitudinal Study of Aging

Yona Lunsky, Centre for Addiction and Mental Health, Ontario

Promoting brain health: A national capacity building project for aging adults with intellectual or developmental disabilities, family caregivers and service providers

Maura Marcucci, McMaster University, Ontario

Mechanisms and prediction of perioperative brain injury and its long-term impact: the NeuroVISION-2 biobank initiative.

Megan O'Connell, University of Saskatchewan, Saskatchewan

Supporting Indigenous Caregivers: Barriers and facilitators to implementing culturally safe dementia caregiver support groups with Indigenous communities and local Alzheimer Societies

Marie Pigeyre, McMaster University, Ontario

Metabolic and Inflammatory Pathways Linking Adiposity to Cognitive Decline : the Canadian Alliance of Healthy Hearts and Minds Biomarker Study

Taylor Schmitz, University of Western Ontario, Ontario

Leveraging deep biology for brain resilience to AD pathology

Katherine Siminovitch, Sinai Health System, Ontario

Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis

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