Heterogeneity of Diabetes: Beta Cells, Phenotypes and Precision Medicine

Heterogeneity of Diabetes: Beta Cells, Phenotypes, and Precision Medicine Symposium
June 2-3, 2021

Webinar Program Booklet

Wednesday, June 2

10:00 am – 10:30 am (EDT)

Welcome Remarks

Dr. Francis Collins – Director, National Institutes of Health (NIH)

Dr. Michael Strong – President, Canadian Institutes of Health Research (CIHR)

Dr. Griffin Rodgers – Director, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH

Meeting Objectives

Dr. Norman Rosenblum – Scientific Director, Institute of Nutrition, Metabolism and Diabetes (INMD), CIHR

Dr. William Cefalu – Director, Division of Diabetes, Endocrinology, and Metabolic Diseases, NIDDK, NIH

Session 1: Islet biology in health and diabetes

Part 1: Islet Microenvironment
Moderators: Jennifer Estall (McGill U) & Alvin Powers (Vanderbilt U)

10:30 am – 12:05 pm (EDT)

Islet microenvironment: islet cell interactions and heterogeneity
Speaker: Mark Huising (U of California Davis)

Heterogeneity in beta cells and stimulus-secretion coupling
Speaker: Richard Benninger (U of Colorado)

Pericytes control islet blood flow, hormone secretion and glucose homeostasis
Speaker: Joana Almaca (U of Miami)

Exocrine pancreas inflammation and islet function
Speaker: Rebecca Hull-Meichle (U of Washington)

Lessons learned from human islet studies
Speaker: Patrick MacDonald (U of Alberta)

Panel Discussion

12:05 pm – 12:20 pm (EDT)

Health Break

Part 2: Islet Engineering
Moderators: Corinne Hoesli (McGill U) & Jeffery Millman (U of Washington School of Medicine)

12:20 pm – 2:00 pm (EDT)

Engineering islet endocrine cells from stem cells
Speakers: Francis Lynn (U of British Columbia)

Engineering the islet vasculature from pluripotent stem cells
Speaker: Juan Melero-Martin (Harvard U)

Engineering islet organoids for immune evasion
Speaker: Eiji Yoshihara (Lundquist Institute)

Engineering bioactive biomaterials for improving cellular replacement therapy
Speaker: Cherie Stabler (U of Florida)

Engineering islets on a chip
Speaker: Maike Sander (U of California San Diego)

Panel Discussion

2:00 pm – 2:15 pm (EDT)

Health Break

Part 3: Beta cell stress and death in diabetes
Moderators: Jim Johnson (U of British Columbia) & Amelia Linnemann (Indiana U)

2:15 pm – 3:35 pm (EDT)

The Precarious Balance Between β-cell Health and Stress in Type 1 Diabetes
Speaker: Carmella Evans-Molina (Indiana U)

Targeting beta cell unfolded protein response in type 1 diabetes
Speaker: Feyza Engin (U of Wisconsin-Madison)

Beta cell senescence in diabetes
Speaker: Peter Thompson (U of Manitoba)

Targeting beta cell stress pathways from cells to clinical trial
Speaker: Anath Shalev (U of Alabama-Birmingham)

Panel Discussion

Session 2: Heterogeneity of diabetic phenotypes before and after diagnosis – Impact on management and treatment

Part 1: Diversity of phenotypes and pathophysiological endotypes. Impact on prognosis and personalized treatment. Current research and knowledge gaps
Moderators: Meredith Hawkins (Albert Einstein College of Medicine) & Christopher Pin (Western U)

3:35 pm – 5:10 pm (EDT)

Dissecting Heterogeneity in Type 1 Diabetes for Precision Medicine
Speaker: Maria Redondo (Baylor College of Medicine)

Unique aspects of Type 2 Diabetes in Youth
Speaker: Kristen Nadeau (U of Colorado)

Type 3C Diabetes: Misdiagnosis, surveillance
Speaker: Melena Bellin (U of Minnesota)

Rare and atypical forms of diabetes-characterization from monogenic to polygenic diabetes
Speaker: Miriam Udler (Harvard Medical School)

Panel Discussion

5:10 pm – 5:15 pm (EDT)

Summary of Day 1
Norman Rosenblum (INMD, CIHR) & William Cefalu (NIDDK, NIH)

Thursday, June 3

10:00 am – 10:05 am (EDT)

Welcome Remarks Day 2

Norman Rosenblum (INMD, CIHR) & William Cefalu (NIDDK, NIH)

Session 2: Heterogeneity of diabetic phenotypes before and after diagnosis – Impact on management and treatment

Part 2: Determinants of pathophysiological and clinical phenotypes. Tools and strategies for their characterization.
Moderators: Anna Gloyn (Stanford U) & Minna Woo (U of Toronto)

10:05 am – 12:05 pm (EDT)

Precision medicine in type 2 diabetes: can we use individual-level clinical features to select optimal glucose-lowering treatment?
Speaker: John Dennis (U of Exeter)

Remission of type 2 diabetes: Insights from patients undergoing bariatric surgery
Speaker: Satya Dash (U of Toronto)

Multiomics/microbiomics profiling for revealing molecular and clinical phenotypes
Speaker: Wenyu Zhou (Tempus Labs)

Precision Diabetes Analysis Using Advanced Technologies
Speaker: Michael Snyder (Stanford U)

Integration of electronic health records and big data as part of multidimensional phenotyping approach
Speaker: Gillian Booth (U of Toronto)

Panel Discussion

12:05 pm – 12:25 pm (EDT)

Health Break

Session 3: Precision Medicine in Diabetes

Moderators: Norman Rosenblum (INMD, CIHR) & William Cefalu (NIDDK, NIH)

12:25 pm – 12:55 pm (EDT)

Translating a Trillion Points of Data into Therapies, Diagnostics, and New Insights into Disease
Speaker: Atul Butte (U of California San Francisco)

12:55 pm – 1:25 pm (EDT)

The future of precision medicine and how it will transform diabetes care
Speaker: Jose Florez (Harvard Medical School)

1:25 pm – 2:00 pm (EDT)

Panel Discussion: Atul Butte, Jose Florez

2:00 pm – 2:40 pm (EDT)

General Symposium Discussion: Considering our increased understanding of the concept of heterogeneity, what does the future look like for diabetes research?

Jose Florez, (Harvard Medical School)
Carmella Evans-Molina, (Indiana U)
Maike Sander, (U of California San Diego)
Miriam Udler, (Harvard Medical School)

2:40 pm – 2:50 pm (EDT)

Wrap Up/Closing Remarks
Norman Rosenblum (INMD, CIHR) & William Cefalu (NIDDK, NIH)

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