Pre-announcement: Heart Failure Research Network Funding Opportunity

This funding opportunity is now available on ResearchNet.

CIHR is hosting an information webinar on June 1, 2021 to outline the goals, objectives, eligibility and requirements of the funding opportunity and to answer questions on how to apply.

A linkage tool is available to facilitate partnerships between interested researchers, organizations and stakeholders. Please note that completing the linkage tool is voluntary. Its use is not a requirement of the application process and in no way confers any advantages in the assessment or funding of applications.

The CIHR Institute of Circulatory and Respiratory Health (ICRH), Institute of Indigenous Peoples’ Health (IIPH), Institute of Aging (IA), Institute of Health Services and Policy Research (IHSPR), and Institute of Infection and Immunity (III) in partnership with the Heart and Stroke Foundation of Canada (Heart & Stroke), Mitacs, and National Institutes of Health – National Heart, Lung, and Blood Institute (NIH-NHLBI) are excited to announce an upcoming funding opportunity for a Heart Failure Research Network.

Anticipated Timelines*

Program Launch: Spring 2021
Webinar(s): Spring/Summer 2021
Registration Deadline: Summer 2021
Full Application Deadline: Winter 2021
Notice of Decision: Spring 2022
Funding Start Date: May 1, 2022
*These timelines are estimates and subject to change.

Overview

The purpose of this funding opportunity is to support a single nationally coordinated, interdisciplinary heart failure research network (including patients, people with lived/living experience, family/caregivers, Indigenous Elders or Knowledge KeepersFootnote 1, government representatives, policy makers, not-for-profit organizations, health care providers, researchers, clinicians and industry) focused on heart failure across the lifecycle, within various health delivery settings (including hospitals, primary care, home and community care, as examples), and must consider heart failure in the context of multi-morbidity, Indigenous health and well-being, and health disparities. The overall goal of the Network is to improve our understanding of the underlying causes, pathophysiology and social determinants of heart failure and to improve the prevention, detection, management, patient outcomes, quality of life, and delivery of care of this common and multifactorial condition.

Applications must include research teams that will engage in team-specific and collaborative research projects. Cross-cutting themes are to be integrated within the network. The Network is expected to include Indigenous health researchers to support Indigenous led solutions, researchers from different relevant disciplines and CIHR research pillars, and people with lived/living experience to offer diverse perspectives.

Heart Failure – A Multifactorial Condition

Long description

Heart failure (HF) is a chronic, progressive and multifactorial condition where the heart is unable to pump enough blood to meet the body's demands for blood and oxygen. The prevalence of heart failure is consistently higher in men than women and occurs across the lifecycle, effecting children, young adults, middle-aged adults and the elderly. A number of risk factors predisposes an individual to heart failure including, but not limited to, determinants of health (social and structural), lifestyle, sex and gender, multi-morbidities and infections. Disease management strategies to address the risk factors for heart failure and/or manage the disease include digital health strategies, novel therapies, remote monitoring, novel models of care, and for Indigenous Peoples; Indigenous-led approaches to well-being. There is an interplay between the disease management approaches and individual risk factors, that when focused on the individual, ultimately determines the most suitable strategies and solutions to improve the prevention, detection, management, and delivery of care of this common condition.

Objectives

The Heart Failure Research Network is expected to:

  • Improve understanding of the underlying causes, social determinants, pathophysiology, prevention, detection and management of heart failure and it’s subtypes (e.g., heart failure with preserved ejection fraction (HFpEF)), including the context of multi-morbidity, Indigenous health and well-being, and health disparities, in Canada through coordinated national research activities across the research pillars to co-create new knowledge, including technical and scientific expertise;
  • Accelerate the iterative, bi-directional translation of evidence into practices, policies and new models of care for improved prevention and patient treatment, care, experiences, quality of life and outcomes through a collaborative national multi-sectoral, multi-pillar, and interdisciplinary approach;
  • Develop, implement, evaluate, and validate interventions and models of care that foster improved heart failure health care delivery and outcomes; and, accelerate the mobilization of research discoveries and best, promising and wise practices to bridge gaps between research outcomes and health impacts; and,
  • Build, foster, and promote relevant research capacity, including training and early career development, by providing high-quality, interdisciplinary training and mentoring through active engagement of established researchers, community leaders, including Indigenous Elders and Knowledge Keepers, early career investigators and trainees.

Research Areas

This funding opportunity will support applications relevant, but not limited to, the following research areas:

  • Mechanistic and Translational Heart Failure Research: for the purpose of this funding opportunity, mechanistic research is defined as studies designed to understand the pathophysiology, prevention, complications and multi-morbidities, including the role of infection and inflammation in these processes, as they relate to heart failure. Translational research is defined as research that advances effective translation and application of knowledge across the expanse of biomedical, clinical and health services delivery domains to improve patient outcomes.
  • Heart Failure Subtyping: To further understand the underlying causes and contributors of the multifactorial heart failure condition, including phenotypic characterization of HFpEF.
  • Disease Management and Models of Care: To further address multi-morbidity and health disparities in the context of heart failure, and including (but not limited to) end of life care, value-based models of care, digital health (including artificial intelligence, remote monitoring, and self-management), care transitions, and rehabilitation.
  • Indigenous Heart Health and Well-being: Indigenous-led approaches that will contribute to improving the health and well-being of Indigenous Peoples.

Funds Available

The total amount available for this funding opportunity is $5,000,000, enough to fund one (1) Network grant at a maximum of $1,000,000 per year for up to five (5) years. This amount may increase if additional funding partners participate. Funding will not be renewable.

Contact information

For general inquiries please contact:

CIHR Contact Centre
Telephone: 613-954-1968
Toll Free: 1-888-603-4178
support-soutien@cihr-irsc.gc.ca

Disclaimer: The information contained in this pre-announcement of the Heart Failure Research Network funding opportunity is subject to change and does not commit CIHR or partners to the requirements outlined in this version. The final funding opportunity will be published by CIHR in the Funding Opportunity Database in ResearchNet in Spring 2021.

™ The heart and / Icon on its own and the heart and / Icon followed by another icon or words are trademarks of the Heart and Stroke Foundation of Canada.

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