Sepsis Question & Answer

  • Questions related to project eligibility
    1. Would prevention of "long-term complications" of sepsis be considered compared to prevention of future sepsis "episodes"?

      Yes, we are interested in the role of pre-existing conditions (including over the counter medication, steroids and immune-suppression) but also concerned with patient outcomes post-sepsis and prevention of re-occurring sepsis complications.

    2. Would the SPOR data collection be in addition or separate from the CIHI data collection related to sepsis? In particular CIHI currently excludes neonates and the population in Quebec.

      SPOR data collection is looking to expand data collection, building off CIHI current data collection framework. Including paediatric and neonatal patient populations are not specific requirements of this application, however applicants can choose to include this patient population as part of the network application.

    3. How would CIHR suggest incorporation of patient/caregivers/family members to biomedical science research?

      Patients/caregivers/family members can be incorporated into research across all four CIHR research themes. For example, a biomedical research project could include patient representation at the Steering Committee level and reflecting on where in the biomedical research spectrum the patient perspective would add value. For more information on patient-engaged research please review the Strategy for Patient-Oriented Research – Patient Engagement Framework.

    4. Fast detection/identification of pathogen via NGS - CompleteGenomics/MBI - are they eligible?

      Applicants that meet the relevant research and eligibility criteria of the funding opportunity will be considered for review by the peer-review panel.

    5. Can basic science projects be included (as a team)?

      The vision for the Sepsis Research Network Initiative is to bring multiple disciplines together, including the spectrum of research across all four CIHR research themes. Basic/biomedical science is part of the CIHR research themes and is to be included as part of a larger Network research program.

    6. Is public education and knowledge translation be in scope?

      Yes, Knowledge Exchange committed to transforming existing and new knowledge generated into better care policies, practices, procedures, products and services for sepsis care across Canada is a required cross-cutting component, and dissemination of results and public education is acceptable as part of the cross-cutting knowledge translation component.

    7. Can clinical trials for new treatment be included for team projects?

      Applicants that meet the relevant research and eligibility criteria of the funding opportunity will be considered for review by the peer-review panel. Clinical trials are not mandatory but can be included as a part of a larger research program.

    8. Can you please clarify the limitation on neonatal and pediatric teams?

      There are no specific limitations to neonatal or pediatric team as part of a Sepsis Research Network. There is no specific requirement for inclusion of neonate or pediatric populations as part of the proposed network.

  • Questions related to Applicants/Team composition/collaborations
    1. Can applicants (either PI or project team member) be involved in multiple applications?

      A Nominated Principal Applicant cannot submit multiple applications to the same competition or the same or similar application to two competitions within the same application period. Principal Applicants may be included in multiple applications, however the goal of the Sepsis Research Network Initiative is to encourage a single, collaborative Full Application.

    2. Can international collaborators participate in each team?

      Yes, while it is not an application requirement it is acceptable to include international participants. Note, the inclusion of international collaborators must follow CIHR guidelines.

    3. How can I find out who would be willing to collaborate with us on this initiative?

      CIHR has developed a researcher linkage tool that enables interested researchers, individuals and organizations to share information and/or forge collaborations.

    4. In order to achieve geographic and gender parity, can each research Team be led by a pair of Principal Applicants?

      The minimum requirement is 1 Principal Applicant to lead each research team (min 3 teams in the network). It is at the discretion of those involved at the application phase if they wish to have more than one Principal Applicant serve as a Team Lead per research team.

    5. How best to include many Early Career Investigators (ECI) on each team - some of whom do not yet have faculty appointments?

      As outlined in the Eligibility requirements on ResearchNet, each Research Team is required to include a minimum of 1 Early Career Investigator (ECI) identified as a Principal Applicant. CIHR defines an ECI as a researcher who, at the time of application, has held a full time, independent research appointment, for a period of 0 to 5 years (60 months). Individuals who do not hold faculty appointments at the time of application do not fulfill the CIHR definition of an ECI. Additionally, Mitacs funding is also available to support the inclusion of post-doctoral fellows and graduate trainees.

    6. If we have to seek researchers out, for example Registered Nurses (RN) or Physical Therapists (PT), do they have to be part of Steering Committee?

      No, as outlined in the Governance section on ResearchNet, it is expected that the Network will develop a governance structure that includes a Network Steering Committee led by the Nominated Principal Applicant (NPA) and representation from each Research Team (Team), each led by a Principal Applicant (PA). In addition, at least one patient representative from the sepsis community must be included as a member of the Committee. Beyond the identified minimum requirements, applicants have the flexibility to compose a well-justified Steering Committee that best meets the needs of the proposed network.

  • Questions related to funding use
    1. What is the $25,000 Letter of Intent (LOI) to be used for?

      The LOI funds must cover the expenses for a minimum of three team members to attend the Strengthening Workshop June 4, 2019 in Edmonton, AB. Aside from Strengthening Workshop participation, the LOI funds can be used as needed by applicants for the development of the Full Application submission.

    2. When can the LOI funds be spent?

      The $25,000 LOI funds is available as of the funding start date of May 1, 2019 and can be utilized up to the Full Application deadline on September 26, 2019.

    3. Can some of the budget of the Sepsis Network grant be used for scholarship competitions that provide funding to trainees?

      In general, yes this approach has be done with previous Networks. Efforts have been made to reduce this re-granting approach, however when used, it is encouraged that these activities remain transparent and reasonable in size and scope.

    4. How does the budget for a Research Network grant differ from a budget for a project grants?

      There are similar components, however budget development must include a reasonable breakdown of funds to be evaluated by the peer-review committee.  It is also imperative that the budget reflects the budget limitations included in the Conditions of Funding section.

  • Questions related to Mitacs Partnership
    1. Will the Mitacs contribution be beyond the $5.8M?

      Yes, any contribution made by Mitacs is in addition to the CIHR funds available identified.

    2. For the Mitacs partnership funds, is there a list of partner companies?

      No, Mitacs does not have a publicly facing list of partner companies, however there is a project database which includes previous partner companies and organizations. While there is no specific list of industry partners, eligibility criteria is available and companies can be vetted for eligibility. Note, any government (municipal, provincial, federal) funded partners are not available.

  • Questions related to Peer Review and funding decisions
    1. Who is CIHR planning to review this Network Grant?

      The review-panel will be developed and recruited by CIHR and will seek to include international representation, experts across the research pillars, representation from appropriate stakeholder groups and ensure conflicts of interest are properly managed.

    2. Will you ensure participation of both basic scientists and clinicians in the review panel?

      The peer-review panel will include representation capable of reviewing and effectively evaluating the trans-disciplinary, multi-research theme application. A full range of expertise, including patient engagement experts, will be a part of the panel.

    3. Can we make LOI and corresponding decisions public if the NPA team agrees, even if they are refused as applicants?

      Successful LOI recipients are posted on the funding decisions database however unsuccessful applicants are not made public. Unsuccessful applicants will be able to contact successful LOI recipients as this information will be posted on the CIHR website.

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