Peer Review Committee Mandates – Project Grant Program

The following table presents an alphabetized list of peer review committees and their corresponding mandates for the Project Grant Program. When applying for funding, you should suggest up to two committees whose mandates most closely align with your research project. Please review the committee mandates before applying in order to correctly identify the best committees for the review of your application.

Behavioural Sciences – A: Neurobiological Basis of Behavioural Processes (BSA)

Basic studies, employing non-human models, in which the primary goal of the study is to establish the neurobiological basis of behaviour. The focus of studies on this committee examine the neurobiological mechanisms of motivation, emotion, stress, drug abuse, feeding, reproduction, learning/memory, pain, motor function and circadian rhythms. Studies exploring non-human animal models of neurological / psychiatric disease, as well as behavioural recovery from stroke or injury, are appropriate, as long as the end points of interest are primarily focused on behavioural measures. Endpoints and behavioural testing should be a core component, essential to addressing the overall research question. Behavioural psychology, Behavioural endocrinology, Neuropharmacology, and Behavioural Immunology studies are also relevant to the committee mandate.

Studies will employ methods which include, but are not limited to, Pavlovian/associative conditioning; instrumental/operant conditioning (including self-administration); behavioural tests of emotional processes, social behaviour, consummatory and reproductive behaviours, etc. Studies using pharmacological or genetic manipulations which study behavioural endpoints are relevant as well as the inclusion of neurophysiology, molecular biology, biochemical assays, as long as the primary goal of the study is to establish the neurobiological basis of a behavioural process or endpoint.

Behavioural Sciences – B: Clinical Behavioural Sciences (BSB)

Clinical or applied studies in psychiatric and neurological populations. Psychiatric populations under study might include but are not limited to subjects diagnosed or at risk for ADHD, psychotic, anxiety, trauma and stress related disorders, mood, personality, alcohol and drug use disorders. Clinical or applied studies of cognition and behavior in neurological populations might include but are not limited to subjects diagnosed or at risk for dementias including Alzheimer’s diseases, Parkinson’s disease, and brain trauma. Methodologies or approaches might include phenotyping, behavioural testing, psychological processing, risk modeling, imaging, genetic and epigenetic analyses, biochemical assays, electrophysiological recordings, and treatment trials (including pharmacological, psychological and behavioural interventions).

Behavioural Sciences – C: Behavioural Studies, Neuroscience and Cognition (BSC)

Mechanistic studies using cognitive, systems, or behavioural neuroscience approaches (in humans or animal models) to study mechanisms of processes in cognition, learning, memory, sensory and motor functions/integration, perception, attention, sleep, pain, speech/language, neuro control of gait. Studies using disease populations are acceptable as long as they inform mechanistic, system-level aspects of normal function or behavioural/neuroscience aspects of the disease. Clinical and/or applied studies in disease populations should be sent to Behavioural Sciences B.

Methodologies used include, but are not limited to, behavioural testing, psychophysics, electrophysiological recordings, brain stimulation, structural and functional neuroimaging, molecular/cellular techniques, neuroanatomy, eye tracking, pain imaging, computational neuroscience, and large-scale network dynamics.

Biochemistry & Molecular Biology – A (BMA)

Structural biology. Biophysical investigations of macromolecules. Membrane proteins and/or bioenergetics (including relevant lipids). Enzymology and enzyme mechanisms. Studies with a primary focus on the structure of protein or nucleic acids.

Biochemistry & Molecular Biology – B (BMB)

Studies on molecular mechanisms of biological systems with a focus on nucleic acid and protein function. In particular: chromatin, chromosomes, organelles; mechanisms and regulation of DNA and RNA metabolic processes and information transfer (e.g., replication, recombination, repair, transcription, processing, splicing, transport, translation).

Note: Studies with a primary focus on the structure of protein or nucleic acids should be referred to the Biochemistry & Molecular Biology – A committee (BMA), and studies with a primary focus on development should be referred to the committee on Developmental Biology (DEV).

Biological and Clinical Aspects of Aging (BCA)

Cellular mechanisms of aging, cell senescence, cellular response to stress. Longevity genes and senescence genes. Mechanisms of exceptional aging, premature aging syndrome. Animal models of aging. Predictive markers of biological health and aging. Molecular and cellular basis of age-related changes in tissues and systems (e.g., osteoporosis and osteoarthritis, age-related decline in immune function, changes in sleep and biological rhythms). Causes, prevention, and treatment of geriatric syndromes, including falls, frailty and functional decline, immobility, delirium, incontinence. Management of chronic pain. Cognitive decline in the elderly.

Biomedical Engineering (BME)

Biomechanical and medical devices including prosthetic devices and artificial organs. Numerical models of physiological systems. Biomaterials. Biomechanics. Regenerative medicine, tissue engineering, repair and regeneration. Organ and tissue preservation.

Note: Gait studies, biomechanical studies dealing with movement and studies with a focus on rehabilitation for movement disorders should be referred to the committee on Movement & Exercise (MOV).

Cancer Biology & Therapeutics (CBT)

Carcinogenesis. Basic and translational aspects of DNA repair, cell cycle/checkpoints and translational control, vaccine, metabolism and gene therapy. Radiation biology. Experimental radiotherapy. Cancer immunotherapy. Cancer prevention approaches.

Cancer Progression & Therapeutics (CPT)

Cancer progression biomarkers, including angiogenesis and host/tumor microenvironment modifications. Development of innovative pharmacological agents and targets. Molecular targeting therapies. Exploratory translational cancer research with a focus on pre-clinical studies. Molecular epidemiology of innovative tumor markers. Development of methods for the early detection, prevention and management of cancer-associated morbidities.

Cardiovascular System – A: Cells and Tissues (CSA)

Research on the heart at the levels of tissues and cells. Electrophysiology, metabolism, molecular biology, cardiac muscle, cell biology. Genetic studies, ion channels, molecular signaling in cardiology, cardiac development, and cardiac tissue cell culture.

Cardiovascular System – B: Heart and Circulation (CSB)

Research on the heart and circulation: hemodynamics, hypertension, myocardial protection, cardiac remodeling, myocardial ischemia and reperfusion, neuro- and endocrine regulation. Studies on cellular and animal models of human cardiac disease. Genetic models of cardiovascular disease states including pharmacogenomics, gene discovery and gene expression studies.

Note: Clinical and clinically-relevant studies should be referred to the Clinical Investigation – D: Cardiovascular Systems (CID) committee.

Cardiovascular System – C: Vascular System (CSC)

Research on the vascular system, including the endothelium, with an emphasis on the cellular, molecular, and immune mechanisms that regulate cardiovascular function in normal and disease states. Atherosclerosis, inflammation and thrombosis.

Cell Biology – Molecular/Fundamental (CB1)

Molecular cell biological mechanisms that govern the basic functioning of cells that include; junctional complexes, endocytosis, secretion, protein sorting, protein traffic, protein degradation, cytoskeleton, organelle biogenesis and dynamics, cell substrate adhesion, cell cycle, protein folding, quality control and cell death. Studies using primarily cell models from multicellular organisms and their healthy or diseased states as well as investigations into inherited diseases that are rooted in defective cellular processes. The focus of this panel is on basic, molecular, and fundamental understandings of cell biology.

Note: Studies of developmental mechanisms using embryonic stem cells, induced pluripotent stem cells, and 3D organoids should be referred to the committee on Developmental Biology (DEV). Structural biology studies should be referred to the Biochemistry & Molecular Biology – A (BMA) committee, and studies focused on gene regulation and transcription to the Biochemistry & Molecular Biology - B (BMB) committee. Studies on obesity should be referred to the committee on Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL). Studies on spinal cord injury and repair should be referred to the committees on Neurosciences (NSA,NSB).

Cell Biology – Disease (CBB)

Investigations examining cell biology mechanisms underpinning acquired diseases. Diseased processes impacting cellular phenotypes that are rooted in one or more mutant or aberrantly expressed proteins. Investigation typically involves model cells, tissue-relevant cells, genetically-modified animals and/or relevant human tissues or cells. Model systems include experimental disease models, iPS cell models, primary cell cultures of relevant disease tissues, etc.

Note: Studies of developmental mechanisms using embryonic stem cells, induced pluripotent stem cells, and 3D organoids should be referred to the committee on Developmental Biology (DEV). Structural biology studies should be referred to the Biochemistry & Molecular Biology – A (BMA) committee, and studies focused on gene regulation and transcription to the Biochemistry & Molecular Biology - B (BMB) committee. Studies on obesity should be referred to the committee on Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL). Studies on spinal cord injury and repair should be referred to the committees on Neurosciences (NSA, NSB).

Cell Biology – Physiology (CBC)

Investigations relating cell biology to cell physiology, cellular and systems networks. Structure/function studies, membrane bioenergetics, cell and organelle dynamics, lipid-protein interactions, model systems including organoids, ion channels, lipid remodeling in organelle biology, channel and protein transport. Systems biology of cellular networks, including computational cell biology, bioinformatics, quantitative cell biology, and molecular modeling, and investigations using simple model systems (yeast, Drosophila, C. elegans, etc.) that inform understanding of cell physiological/biological responses and mechanisms in the context of health and disease.

Note: Studies related to skeletal muscle contraction should be referred to the committee on Movement & Exercise (MOV). Studies related to cardiac muscles should be referred to the committee on Cardiovascular System – A: Cells and Tissues (CSA). Studies related to systems biology of development or 3D organoids to study development should be referred to Developmental Biology (DEV).

Clinical Investigation – A: Reproduction, Maternal, Child and Youth Health (CIA)

Clinical and clinically-relevant studies on reproductive, maternal, foetal, neonatal, infant, child and youth health.

Note: Studies related to reproductive and developmental endocrinology, hormonal basis of fertility control and infertility, hormonal regulation/control of pregnancy and parturition as well as puberty should be referred to the Endocrinology (E) committee.

Studies related to social and developmental aspects of children's and youth's health, should be referred to the Social & Developmental Aspects of Children's & Youth's Health committee (CHI).

Clinical Investigation – B: Arthritis, Bone, Skin and Cartilage (CIB)

Clinical and clinically-relevant studies in arthritis, bone, cartilage and dermatology. Joint diseases and rheumatology; orthopaedics; bone and mineral metabolism; oral and craniofacial structures, and wound healing.

Note: For applications related to dental and oral health research, also refer to the Systems and Clinical Neuroscience (NSA) and the Developmental Biology (DEV) committees.

Clinical Investigation – C: Digestive, Endocrine and Excretory Systems (CIC)

Clinical and clinically-relevant studies in metabolic and endocrine disorders; gastroenterology, hepatology, nephrology, urology, hematology and related viral and microbial pathologies.

Clinical Investigation – D: Cardiovascular Systems (CID)

Clinical and clinically-relevant studies on the heart and circulation: hemodynamics, hypertension, myocardial protection, cardiac remodeling, myocardial ischemia and reperfusion, neuro- and endocrine regulation. Cardiovascular clinical pathophysiology, diagnosis and therapeutics, arterial and venous vascular disease.

Commercialization (CMZ)

Projects for which a product/process/service to be commercialized has been identified; the intellectual property (IP) and an IP protection strategy have been identified and described; and the IP is (or has been) subjected to an initial technology assessment. Research to determine the potential for commercial viability or other opportunities for use of IP, to enhance or strengthen the value of IP (or IP portfolio) and improve the business prospects or potential for downstream investment in the technology; promote academic health research and technology transfer activities that support and accelerate commercialization of the technology. The IP may (or may not) have acquired interest from partners willing to invest in the new technology, and an existing license or option to license the technology does not disqualify the project.

Note: Applications focused solely on prototype construction will not be considered. Research to help the academic community and Canadian industry/companies with an interest in health R&D to work together should be considered by a discipline-based committee.

Developmental Biology (DEV)

Pattern formation, cell determination and differentiation, specification of tissue type during development. Morphogenesis. Embryology. Teratology. Genetic and molecular aspects of gene expression, cell pluripotency and differentiation during development. Cell-cell communication and signal transduction mechanisms in development. Post-transcriptional controls of developmental processes. Targeted disruptions of developmental control genes. Studies of developmental mechanisms using embryonic stem cells, induced pluripotent stem cells, and 3D organoids. Developmental neurobiology.  Systems biology of development.

Note: Developmental Biology (DEV) committee will review applications related to the developmental aspects of the oral function. Studies using systems biology approaches or 3D organoid cultures informing understanding of cell physiological/biological responses and mechanisms in the context of health and disease not related to developmentshould be referred to Cell Biology - Physiology (CBC).

Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL)

Molecular, cellular and whole organism studies of carbohydrate, lipid and energy metabolism as related to both fundamental and translational biology of diabetes, obesity, insulin resistance and dyslipidemia. Protein Metabolism.

Note: Population studies and human studies related to nutritional aspects of obesity and diabetes, or the relation between diet and health should be referred to the committee on Nutrition, Food & Health (NUT). Studies on the immunology of type 1 diabetes should be referred to the committee on Immunology and Transplantation (IT).

Endocrinology (E)

Biology of endocrine organs/tissues and mechanisms underlying endocrine disorders including those related to hormones and cancer as well as those related to the neuroendocrine, cardiovascular and renal systems.

Male and female reproductive endocrinology. Hormonal basis of fertility control and infertility. Gonads and the hormonal control of gametogenesis. Development and differentiation of endocrine tissues including developmental origins of endocrine dysfunction. Endocrinology of pregnancy and parturition.

Examples of study areas include but are not limited to: regulation of peptide and polypeptide hormone synthesis/processing and receptors; steroid hormone synthesis/metabolism, binding proteins and receptors; hormone signaling pathways and regulation of target genes; mechanisms of hormone action and endocrine disruption; development and/or differentiation of endocrine cells; biochemical and genetic/molecular basis of endocrinopathies; hormonal regulation/control of puberty; hormonal regulation/control of pregnancy and parturition; endocrine function of placenta; hormones and cancer; neuroendocrinology; hormonal regulation/control of aging.

Note: Studies related to diabetes should be referred to the committee on Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL).

Gender, Sex & Health (GSH)

How sex (biological factors) influence mechanisms of disease, health and behaviour; how gender-related factors (psychosocial characteristics) influence health status, outcomes, behaviours and health-services use. Sex and gender can influence health independently and/or interdependently and intersect with multiple social structures. Such influences are dynamic across time, necessitating an intersectional life span approach.

Applicants must address sex and / or gender influences in all aspects of the application, including but not limited to the significance of the study, hypothesis (es) or research questions(s), choice of research method, specific animal, cell or tissue model or target human population, choice of measurement tools, recruitment strategies, power calculations (in particular when the target health issue has a well-established gender bias), data analytic strategies, and potential interpretive challenges. Studies that aim to advance methodologies related to the study of sex and gender influences on health would also fall under the mandate of this committee.

Single -sex or -gender studies may be considered but must include a clearly-articulated rationale. Single-sex proposals that address specific women’s or men’s health issues will also be considered by this committee. However, gendered aspects of the health issues in question should be considered and investigated whenever potentially relevant.

Note: Clinical and clinically-relevant studies having a primary focus on reproductive and maternal health should be referred to the Clinical Investigation – A: Reproduction, Maternal, Child and Youth Health (CIA) committee. Studies related to male and female reproductive endocrinology, and hormonal basis of fertility control and infertility should be referred to the Endocrinology (E) committee.

Genetics (G)

Inherited diseases and disease susceptibility; mutation and mutational mechanisms; modeling of human genetic diseases; genotypes, phenotypes and natural history of genetic diseases; metabolic genetics; population and statistical genetics; cytogenetics; epigenetic inheritance and gene regulation; genetics of DNA repair, replication and recombination; gene and gene-based therapies.

Genomics: Systems and computational biology (GMX)

Technical or conceptual advances in genome research related to high-throughput sequencing and genotyping technologies. Conceptual and technical advances in meta-genomic analysis, functional genomics; including molecular systems-level analysis that apply large-scale, genome-wide techniques. Application of synthetic biology approaches to genome research and advances in proteomics, epigenomics or bioinformatics as they relate to any of these problems. Computational algorithms and software development for –omic/genetic data.

Note: Research involving a major component of biochemical/molecular methods not addressing genomic, proteomic or systems approaches may be considered beyond the Genomics committee mandate.

Health Policy & Systems Management Research (HPM)

Health policy and politics. Health economics (e.g., health economic evaluation, health system financing, health remuneration methods and health resource allocation mechanisms). Health systems management (e.g., health administration, health organizational behaviour and governance, health systems analysis, integrated health systems, and managed health care). Health human resources (e.g., structure/organization/education of health professions and availability of appropriate health professionals to provide necessary services to disadvantaged populations).

Note: Studies in which the primary focus is on children and youth, the elderly, or gender issues should be referred to the committees on Social & Developmental Aspects of Children's & Youth's Health (CHI), Social Dimensions in Aging (SDA), or Gender, Sex & Health (GSH).

Health Services Evaluation & Interventions Research (HS1)

The HS committee reviews applications that use health services research methods and/or approaches to examine:

Health services, interventions or programs delivered by health professionals and/or other care providers to individuals and/or their advocates and may incorporate individual, community and/or group-level outcomes (such as health status, quality of care, effectiveness, efficiency, accessibility, costs, and equity);

Innovative methods and tools for studying health services, interventions or programs delivered by health professionals and/or other care providers to individuals and/or their advocates and may incorporate individual, community and/or group-level outcomes;

Education, training or other interventions targeting health professionals and/or other care providers related to the delivery of health services, interventions or programs to individuals and/or their advocates and may incorporate individual, community and/or group-level outcomes.

The health services, interventions or programs may relate to any setting, level of care condition, population, or mode of delivery.

Note: Education training related to general competency, distribution, or supply of health professionals and/or unpaid care providers should be referred to the Health Policy & Systems Management Research (HPM) committee.

Studies aligned with the mandate of the Social & Developmental Aspects of Children's & Youth's Health (CHI) committee with a focus on child and youth development, familial, parental, and social influences on the health of children should be referred to the CHI committee. Studies aligned with the mandate of the Social Dimensions in Aging (SDA) committee with a focus on the elderly should be referred to the SDA committee. Studies where gender issues are a primary focus should be referred to the committee on Gender, Sex & Health (GSH).

Hematology, Digestive Disease & Kidney (HDK)

Studies of mechanisms of disease including cellular physiology and molecular biology with a special interest in translational research. The focus on disease in the following systems: hematology, gastroenterology and hepatology, nephrology, and urology.

Note: Clinical and clinically-relevant studies should be referred to the Clinical Investigation – C: Digestive, Endocrine and Excretory Systems (CIC) committee.

Humanities, Social Sciences, Law & Ethics in Health (HLE)

Health research from the humanities (including but not limited to history, philosophy, law, literary studies, cultural studies, narrative analysis, arts based or performance research, communication or media analysis) or social sciences (including but not limited to health studies, sociology, anthropology, religious studies, political science). Research in health ethics (e.g. clinical ethics, research ethics) and health law. Research proposals can be critical, theoretical, methodological or empirical in nature, in accordance with disciplinary standards.

Note: Studies having a primary focus on health services or evaluation of services should be referred to the Health Services Evaluation & Interventions Research (HS1) committee. Studies related to the determinants of health should be referred to the Psychosocial, Sociocultural & Behavioral Determinants of Health (PB1) committee. Studies with an emphasis on health policy should be referred to the Health Policy & Systems Management Research (HPM) committee. Studies related to population and public health should be referred to the Public, Community and Population Health (PH1) committee. Studies in which the primary focus is on children and youth health, the elderly, or gender issues should be referred to the committees on Social & Developmental Aspects of Children’s & Youth’s Health (CHI), Social Dimensions in Aging (SDA), or Gender, Sex & Health (GSH) committees.

Immunology & Transplantation (IT)

Research in host innate and adaptive immunity at the molecular, cellular, whole animal or human levels. Developmental, genetic and cell biology studies with a primary focus on immune cells and their molecules (e.g. antibodies, cytokines). Systems biology of immune responses. Studies on inflammatory and/or immune-mediated diseases (autoimmune diseases, allergy, hypersensitivity responses) emphasizing immune pathogenesis rather than target organ injury or function. Cell and solid organ transplantation and induction of tolerance. Studies on novel immunotherapies such as vaccines and biologicals when emphasizing novel immune mechanisms.

Note: Studies in which the primary focus is on organ preservation for transplantation should be referred to the Biomedical Engineering (BME) committee.

Studies having a primary focus on transplantation surgery should be referred to the relevant discipline-based committee.

Indigenous Health Research (IHR)

This committee reviews applications with a central focus on carrying out ethical and culturally competent research involving Indigenous peoples, with the intent to promote health through research that is in keeping with Indigenous values and traditions and follows the TCPS 2 - Chapter 9 – Research Involving the First Nations, Inuit and Métis Peoples of Canada guidelines. This includes applications from all four themes (pillars) of research that use disciplinary and interdisciplinary approaches to Indigenous health research.

The overarching goal of Indigenous health research is to inspire, promote and support research with the highest potential to advance health and wellness for Indigenous peoples, grounded in commitment to deep community-engagement, partnership and collaboration in research and knowledge translation. The integration of concepts of service to community within the very definition of scientific and scholarly excellence is a distinguishing feature of Indigenous health research.

While service to community is a core principle this does not, in any way, deny or contradict the central role of discovery-based, curiosity-driven research in the field of Indigenous health. The pursuit of knowledge for its own sake is clearly a legitimate form of Indigenous health research, though it too is expected to be pursued in appropriate partnership and collaboration with Indigenous communities.

The committee reviews applications using the full range of relevant disciplinary methodologies, with an emphasis on the integration of advanced health research methods with community-based approaches, multi-sectoral partnership models, participatory action research, and Indigenous methodologies. Investigations that contribute to capacity-building for both the advanced health research community and Indigenous peoples are encouraged.

Note: Applicants will need to indicate in their proposal how their project addresses the principles of the Tri-Council Policy Statement (TCPS 2) - Chapter 9 on Research Involving the First Nations, Inuit and Métis Peoples of Canada and Indigenous partnering community/organizational ethical guidelines.

Applications that do not fit within the IHR mandate will be reviewed by another relevant discipline-based committee.

Knowledge Translation Research (KTR)

Research directed toward developing theory, evidence and innovation to define the determinants, implementation and uptake of health research evidence into practice. Research on: determinants of knowledge application; effectiveness of interventions to promote knowledge application; and evaluation and impact of knowledge application on health and other patient outcomes, professional practice, and policy. Research into the promotion of knowledge translation through informed policies and clinical practices aimed at improving the quality and dignity of life for the patients.

Note: Applications on systematic reviews should be referred to the relevant discipline-based committee.

Medical Physics & Imaging (MPI)

Development and optimization of medical imaging technologies such as magnetic resonance imaging, x-ray computed tomography, ultrasound, nuclear medicine, molecular and optical imaging, usually in conjunction with their validation and application in either pre-clinical models or clinical populations. Radiation therapy and biophysics technology development, computational and experimental methods and translation, radiation science investigations at both clinical and basic science level. Technical advancements can include software (e.g. acquisition and post-processing) and/or hardware, as well as novel applications of existing methods.

Note: Application studies using off-the-shelf methods without technical innovation are best suited to the appropriate systems/disease relevant committee.

Microbiology & Infectious Diseases (MID)

Molecular microbiology and microbial physiology with an emphasis on (non-viral), bacterial, fungal and parasite pathogenesis and host-pathogen interactions including the study of virulence factors. Diagnosis and therapy of infectious diseases; vaccine discovery and development. Antimicrobial mechanisms and resistance. Drug discovery and new therapeutics, including alternates to antibiotics. Mechanisms of evasion of innate or adaptive immunity by pathogens, with a focus on the pathogen. Contributions of microbes and the microbiome to health and development of the host.

Note: Virology applications should be directed to the Virology & Viral Pathogenesis (VVP) committee. Applications that are focused on studies of a pathogen should be directed to the Microbiology & Infectious Diseases (MID) committee. Applications that are focused on the host's responses to a pathogen (i.e., where the pathogen is used as a tool to investigate immune responses) should be directed to the Immunology & Transplantation (IT) committee.

Molecular & Cellular Biology of Cancer (MCC)

Fundamental molecular, cellular and genetic mechanisms of cancer etiology including discovery research relating to fundamental tumorigenic processes. These include cell signaling, cell cycle/proliferation, stromal-tumor interactions, angiogenesis, carcinogenesis, stem cell fate/differentiation, epigenetics, growth regulation, apoptosis and metastasis. Molecular, cellular and genetic approaches as well as the use of model organisms.

Movement & Exercise (MOV)

Gait studies, biomechanics. Skeletal muscle biology, fibre typing and regulation. Skeletal muscle contraction. Movement disorders, neuromuscular disorders, myopathies. Sensory motor integration. Exercise physiology, role of exercise in health promotion and rehabilitation. Rehabilitation and physical therapy. Orthopaedics applied to the articular system. Occupational ergonomics. Kinesiology. Health and physical fitness.

Note: Studies related to cardiac muscles should be referred to the Cardiovascular System – A: Cells and Tissues (CSA) committee.

Systems & Clinical Neurosciences (NSA)

Studies on systems neuroscience and the description and analysis of the circuitry underlying conscious and autonomic behavior, network dynamics and changes in circuit function. Studies on cellular and molecular mechanisms of adult onset neurodegenerative diseases of all types. Studies on axonal regeneration, neural circuit repair, and recovery of function. Neuronal death, axonal and dendrite degeneration, protein misfolding, aggregation, processing, neuroinflammation, mitochondrial deficits and vascular pathology. Role of endogenous neurogenesis and stem cell biology in the repair of the nervous system. Motor, sensory, homeostatic systems, and disorders including epilepsy, Alzheimer's disease, Parkinson's disease, stroke, pain, and loss of vision and hearing.

Approaches: Studies in this panel will employ methods that include, but are not limited to, animal models of neurodegenerative diseases and/or neuronal injury, molecular and cellular approaches to study mechanisms of disease and repair, gene transfer/therapy, drug and pharmacological approaches, imaging, and functional assays including electrophysiology and behavior.

Note: Basic research using primarily behavioural measures and endpoints should be referred to Behavioral Neuroscience A (BSA). Human, clinical or applied studies in psychiatric and neurological populations should be referred to Behavioural Sciences B (BSB) or another relevant clinical committee. Studies on large-scale network dynamics and computational neuroscience should be sent to Behavioural Sciences C (BSC). Research on nervous system development should be referred to the committees on Developmental Biology (DEV) or Molecular & Cellular Neurosciences (NSB). Fetal, neonatal, paediatric, childhood studies should be referred to Clinical investigation A - Reproduction, Maternal, Child and Youth Health (CIA)

Molecular & Cellular Neurosciences (NSB)

Studies on molecular and cellular neurosciences, neurobiology, neurotransmitters and signaling molecules, cellular and molecular mechanisms of neurological disorders. Axonal and dendritic development; synaptogenesis and activity-dependent development; development of motor, sensory and limbic systems; ligand- or voltage-gated ion channels; G-protein linked receptors; neurotransmitter release; synaptic transmission and synaptic plasticity; neuronal excitability. Cellular and molecular mechanisms of neurological disorders.

Note: Studies on neural networks, network dynamics, clinical and system neuroscience, and sensory systems should be referred to the committee on Systems & Clinical Neurosciences (NSA). Studies related to skeletal muscle, myopathies, kinesiology and exercise should be submitted to the committee on Movement and Exercise (MOV).

Nutrition, Food & Health (NUT)

Human nutrition through the life span. Dietetics. Obesity including evaluations of new glucose and weight-lowering drugs. Energy balance and nutrition. Health consequences of specific diets and dietary supplements, nutritional factors in the etiology of metabolic and gastrointestinal disorders, the epidemiological association between dietary habits and disease incidence. Food intolerance and allergy. Nutrition-related education and health promotion. Diabetes prevention and education. The influence of socioeconomic, cultural and political factors on nutrition of the individual and the community. The impact of nutrient intake on disease response, work performance, and behaviour. Population and life cycle nutrient use and requirements. Pathogenesis of nutrient imbalance. Non-oral feeding strategies. Food production techniques, and food handling and safety. Probiotics. Nutrigenetics and nutrigenomics, including machine learning approaches.

Pharmaceutical Sciences (PS)

Research on drug design and delivery. Medicinal chemistry, radio-pharmaceuticals, biopharmaceutics and drug analyses. Pharmacognosy. Pharmacokinetics.

Pharmacology & Toxicology (PT)

Research on drug metabolism and toxicology. Drug abuse and addiction. Mechanisms of drug action. Characterization of drug targets. Pharmacology of biological substances. Clinical pharmacology. Pharmacogenetics.

Psychosocial, Sociocultural & Behavioural Determinants of Health (PB1)

Behavioural and social sciences research applied to physical and mental health, health behaviour, psychophysiology, community health and well-being across the life course including palliative and end of life care. Focus on behavioural, psychological, social, cultural, environmental, and contextual perspectives, as they relate to health promotion, prevention, mechanisms, disease processes, outcomes, treatment, and intervention.

May also include psychometric measurement, knowledge synthesis, behavioural medicine, clinically applied projects, or efficacy trials. Projects typically emphasize conceptual models, theory testing, a priori hypotheses, well-justified methodological design, rigorous measurement criteria and sound data analyses. Quantitative/qualitative/mixed-method approaches and experimental/cross-sectional/prospective/retrospective designs are considered. Individual or population perspectives can be adopted, targeting healthy, at-risk, or clinical samples.

Public, Community & Population Health (PH1)

The conception and measurement of exposures and health status and the testing of hypotheses concerning exposure/disease relationships. Such epidemiologic studies range from gene/environment interactions in the biological origins of disease to the impact of social environments, including disadvantaged populations' status, on health and functional status; Research on the etiology of human disease and disability; Population health intervention research to produce evidence about implementation and outcome of programs, and distribution approaches that have the potential to improve health at the population level; and Health ethics and health law related to public, community and population health. The mandate includes the development or application of novel statistical methods, the measurement of burden of disease in populations, global health, health inequalities and gradients, health of diverse and disadvantaged populations, health promotions, water safety and the impact of global change on health.

Note: Studies aligned with the mandate of the Social & Developmental Aspects of Children's & Youth's Health (CHI) committee with a focus on child and youth development, familial, parental, and social influences on the health of children should be referred to the CHI committee. Studies aligned with the mandate of the Social Dimensions in Aging (SDA) committee with a focus on the elderly should be referred to the SDA committee. Studies where gender issues are a primary focus should be referred to the committee on Gender, Sex & Health (GSH). Studies aligned with the mandate of the Nutrition, Food & Health (NUT) committee with a focus on nutrition or food safety should be referred to the NUT committee.

Randomized Controlled Trials (RC1)

Studies in which investigators randomly assign eligible human research participants or other human units of study (e.g., classrooms, clinics, playgrounds) into groups to receive or not receive one or more interventions that are being compared. The results are analyzed by comparing outcomes in the groups. Studies relating to the development of methodologies for the design and conduct of randomized clinical trials. The RC1 panel is multidisciplinary across the spectrum of CIHR's mandate.

Respiratory System (RS)

Lung and associated tissue. Lung mechanics. Pulmonary circulation. Respiratory control mechanisms. Airway smooth muscle. Neuro-control of breathing. Destructive and obstructive lung diseases. Sleep-related disorders. Respiratory diseases of the newborn. Non-microbial diseases of the adult. Surfactant. Acute lung injury. Lung inflammation. Asthma and allergies. Determinants of respiratory diseases (gene-environment interactions).

Social & Developmental Aspects of Children's & Youth's Health (CHI)

Conditions for optimizing child and youth health, development and well-being. Causes, risk, early prevention treatment and long-term management strategies for support of children and youth with physical, mental, congenital and behavioural health challenges with consideration of school-related issues and issues related to the official language minority status. Environmental, life style and social influences on reproductive, maternal, foetal, neonatal, infant/ child and youth health. Health impacts and outcomes of family environment, family dynamics and level of care during childhood including impacts of poverty.

Note: Projects related to biological and clinical aspects of children's and youth's health should be referred to the Clinical Investigation – A: Reproduction, Maternal, Child and Youth Health (CIA) committee. Studies using animal models should be referred to the CIA committee.

Social Dimensions in Aging (SDA)

Social factors as determinants of health and quality of life in aging (e.g., social support, work, participation of the elderly persons in society, leisure and recreation, household and family structure, housing, transportation, economic status and inequality, retirement). Positive health behaviours and healthy life styles, physical activity. Life-course interactions and transitions. Long-term care and caregiving for the elderly, including assisted or supportive living facilities, and care at home. Health services for the elderly, including those living in rural, northern, and official language minority communities. Palliative care: pain management, individual and family support, choice of settings and implications of choices, strategies for implementing end-of-life guidelines. Epidemiological studies and surveys of problems related to palliative and end of life care. Studies of social factors affecting specific age-related physical, cognitive, communications, behavioural, and mental health problems. Elder abuse and neglect.

Virology & Viral Pathogenesis (VVP)

Virology. Virus-host interactions. Immunology as related to viruses. Diagnosis and therapy of viral diseases. Antiviral resistance.

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