The Bhagirath Singh Early Career Award in Infection and Immunity 2013 Recipient
Dr. Irah L. King
Department of Microbiology and Immunology
Dr. King's research interests
As we all know, the immune system is there to protect us from infections (bacteria, viruses), and substances that appear foreign and harmful. Specific antibodies generated by the immune system significantly contribute to effective protection overall, and are a fundamental property of the adaptive immune system. However, this system may go wrong, especially when antibodies react to self antigens, leading to autoimmune diseases or allergic reactions. These antibody responses require highly coordinated interactions between B cells and helper T cells. Dr. King’s research interests include:1) the cellular and molecular requirements for the differentiation and persistence of a subset of helper T cells, 2) how T-B cell interactions generate protective humoral immunity to intestinal infection, and 3) the impact of microbiota on humoral immune responses within the gastrointestinal tract.
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